Posted by admin on Feb 28, 2023 in |
Medicinal plants are an abundant source of bioactive compounds, which have been used for thousands of years against different diseases because plants have antibacterial, anti-inflammatory, and antifungal activities. All of the medicinal plants that may be found on earth today have specific therapeutic use and importance. Our research work is based on the qualitative phytochemical studies of extract obtained from leaves of Tinospora cardifolia, Punica granatum, Moringa oleifera, Momordica charantia, Annona squamosa, Eugenia jambolana, and Carica papaya were collected from Bhadravathi taluk of Shivamogga district. These leaf extracts were prepared using various solvents like methanol, acetone, chloroform, and aqueous. Phytochemical screening of these medicinal plants showed the maximum amount of alkaloid, flavonoid, phenol, terpenoid, and tannin in all the extracts. However, methanolic extracts showed good results when compared to other solvent systems. The phytochemical screening of these medicinal plants is commercially very significant and is very important for producing new medication for the treatment of different...
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Posted by admin on Feb 28, 2023 in |
Aluminium neurotoxicity is implicated in Alzheimer’s disease, this multifactorial disorder, with neurodegeneration and dementia as hallmarks. Aluminium toxicity is due to imbalances between free radicals and antioxidants formation, leading to oxidative stress. However, protection against aluminium toxicity is yet to be fully realized. Therefore, this study investigated Zingiber officinale (ZO) neuroprotective potential against aluminium chloride (AlCl3)-induced neurotoxicity in Swiss mice. Forty-eight animals were divided into eight groups (n=5) with treatment lasting three weeks: Group 1 (control) received 1 ml/kg of distilled water, while groups 2-8 respectively, received AlCl3 (100 mg/kg), donepezil (2.5 mg/kg), ZO ethanol extract (474 mg/kg, 949 mg/kg and 1,423 mg/kg), ZO dichloromethane extract (949 mg/kg), and ZO n-hexane extract (949 mg/kg). Morris water maze test was performed, and the mice were sacrificed. Brain homogenates were assayed for catalase (CAT) and glutathione peroxidase (GPx) levels. AlCl3 treatment led to significantly (p<0.05) high escape latency and less latency in the hidden platform quadrant and reduced brain CAT and GPx levels compared with the control. The groups treated with...
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Posted by admin on Feb 28, 2023 in |
Background: Previous hospitalization, nosocomial infection and specific risk factors like prolonged quinolone use for Spontaneous Bacterial Peritonitis prophylaxis can be related to drug-resistant bacterial infections and high mortality in liver cirrhosis. Aim and Objectives: To study the prescription pattern of antibiotics used in SBP, compare the efficacy and emerging resistance of antibiotics, and classify patients with different types of ascites. Methodology: The study was conducted in liver cirrhosis patients with SBP retrospectively (2 years) and prospectively (6 months) by a convenient sampling technique. The study was carried out in NIMS Medicity, Thiruvananthapuram. Relevant data were collected via pre-approved data collection form and were subjected to SPSS statistics 22 and R software 4.1.1. analysis. Results: In our study, a total of 116 patients in the retrospective and 21 patients in the prospective study were obtained. 26 patients (22.4%) from the retrospective study and 4 patients (19%) among the prospective study had culture-positive ascitic fluid culture. E. coli was the most commonly obtained organism (69.24%). Third-generation cephalosporins showed higher resistance in...
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Posted by admin on Feb 28, 2023 in |
Streptococcus mutans is the primary major causative agent of dental caries, with the ability to produce acid and form dental plaque. Streptococcus mutans adheres to the tooth surface via extracellular enzymes and produces dental plaque via extracellular polysaccharides synthesized from sucrose via glucosyltransferase and fructosyltransferase. This study aimed to look at the alternative antimicrobial agent from plant extracts against Streptococcus mutans. Streptococcus mutans were used to assess the antimicrobial activities of crude plant extracts. Five different plant extracts were examined using the agar well diffusion method and were found to be antibacterial against Streptococcus mutans; Saponin, Proteins, Tannins, Flavonoids, Steroids, and reducing Sugars were found in the phytochemical screening of selected medicinal plants. Among the different extracts, Methanol had the highest antibacterial activity due to its increased solubility of highly active antimicrobial and phytochemical components. The extract has the potential to be a new source of antibacterial agents, and it scientifically justifies the use of plant extracts as an alternative antimicrobial agent against antibiotics, which shows various side...
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Posted by admin on Feb 28, 2023 in |
The heterocyclic compounds are formed by the hetero atoms (O, S, N, etc.) in the cyclic ring system. These are mainly started from 3- membered to 10- membered heterocyclic rings. The compound containing heterocyclic molecules shows potent activity in various pharmacological targets. Benzothiazole is a fusion of a benzene ring with a 5-membered thiazole ring which is widely used in heterocyclic compounds. The benzothiazole pharmacophore and its derivatives are used for the development of novel drugs and have also shown different pharmacological and biological activities such as anticancer, antibacterial, antifungal, anti-inflammatory, analgesic, anti-HIV, antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial activities. In previous years, few new benzothiazoles have been shown with different biological responses. In such a manner, this review illuminates the benzothiazole and its substituted product that possesses distinct biological activity. This article discovered a novel benzothiazole-based drug that has shown less toxic and more active...
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