Posted by admin on Jan 31, 2023 in |
The word inflammation comes from the latin word called “inflmmare” which means “To set on fire”. It is a complex biological process that is mediated by several chemicals and biological mediators like pollens, irritants, pathogens and damaged cells. The body’s inflammatory reaction destroys such chemical and biological mediators and gets rid of injured tissues. But in chronic state this inflammation seems to produce symptoms that are quite serious and may be life-threatening. Solanum torvum Sw. is a normal weed found in road side and abandoned field very often in Assam, but it’s berries are used by the Tiwa tribe of Morigaon district, Assam, to treat painful inflammation caused due to trauma or any kind of infection. It is quite common among the tribe to coat the inflamed area with fresh raw berry paste of Solanum torvum Sw. for 2 to 3 days, they take the bitter juice of berries as drink. The author have carried out both in-vitro and in-vivo experiment on the anti inflammatory properties of this berry...
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Posted by admin on Jan 31, 2023 in |
Background and Aim: In-silico approach is commonly the method for predicting and confirming drug design. Hence the present study was undertaken to evaluate in-silico the anti-ulcerative activity of some bioactive compounds from Cassia tora and Butea monospora through a molecular docking approach. Method: Docking is performed using 22 runs of the Lamarckian Genetic Algorithm with the grid box sized x, y, and z coordinates of (20.7075) X (38.7045) X (–33.7057) and spacing of 0.375 Å on Autodock suits software 2. The docking data are then evaluated with the Autodock Tools suite software, and the interaction is displayed with the Biovia Discovery Studio Visualizer. Result: Kaempferol (5280863) and Gallic acid (370) of Cassia tora and Butea monospora showed that the value -8.7 kcal/mol and -8.3 kcal/mol for binding energy, respectively, though binding energy of standard of ligand ranitidine (3001055) is -5.4 kcal/mol. Kaempferol and gallic acid are strongly tied to GLU374 ARG846 ARG775 PHE778 ASP779 LEU843 ARG949 ASP851 and TYR799 CYS813 LEU811, respectively, on the active site of the receptor....
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Posted by admin on Jan 31, 2023 in |
Medicinal herbs have an important role in illness prevention, and their promotion and usage are compatible with all current disease preventive techniques. Pueraria tuberosa, widely known as kudzu, is a climber with tuberculated woody stems. It has exhibited Cardio-tonic, Aphrodisiac, Abthyperglycemic Galactogogic, and anti-lipidemic characteristics Daidzin, Puerarin, Puerarone, Genistein, Puetuberosanol, Tuberostan, Tuberosin and Puerarin 4′,6′ diacetate are all found in high amounts in the tubers of Pueraria tuberosa. Numerous bioactive phytochemicals, mostly Isoflavonoids such as Puerarin, Genistein, Daidzein and Tuberosin, were soon identified in the tuber. In the present study, three types of studies, Pharmacognostical Studies, Phytochemical Studies, and Pharmacological Studies, have been done using methanolic extracts of tuber powder; Pharmacognostical Studies include organoleptic evaluation, microscopical evaluation, and physical evaluation. In pharmacological studies, analgesic activity was recorded using the Hot plate Method. A suitably designed transverse section of the tuber was studied and different tissue organizations were viewed at 10x and 40x. Foreign organic matter, ash values, extractive values, moisture content, swelling index, and foaming index were all measured,...
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Posted by admin on Jan 31, 2023 in |
Background: Caesalpinia bonducella F. (Leguminosae) has long been used in traditional medicinal treating methods. It has high therapeutic values in India Ayurveda. They contain tannin, saponins, flavonoids, and alkaloids. The seeds of Caesalpinia bonducella are claimed to be styptic, purgative, anthelmintic and cures inflammations. Today the interest in traditional medicine and demand for more plant-based drugs has increased. Here the study is focused on anti-inflammatory efficiency and analysis of phytochemical compounds from the Caesalpinia bonducella seed kernel extract. As part of the immune response, inflammation plays a significant role in defending or protecting the body against pathogens like viruses, bacteria, fungi, and other parasites. Inflammation leads to a complete detriment at the sites of inflammation and promotes the renewal or regeneration of normal tissues. During inflammation, Chemotaxis is the event with cells like Fibroblasts, leukocytes, Macrophages, and Tumor cells are involved in the migration of cells towards a chemical signal in the cell’s surrounding environment. Our research focuses on unravelling the anti-inflammatory efficacy of ethanolic fraction, which comprises the...
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Posted by admin on Jan 31, 2023 in |
During the severe worldwide pandemic caused due to SARS COV-2 Corona virus, Favipiravir has been used for the treatment. It is a water insoluble anti-viral drug with poor dissolution and poor flow properties, resulting in poor oral absorption and less bioavailability. For a long time, the phrase “direct compression” was used to describe the compression of a single crystalline component into a compact without the addition of any other materials. Using excipients and solvents, the crystallo-co-agglomeration process aggregates drug crystals in the form of small spherical particles to create an intermediate product with better micromeritic and mechanical characteristics, solubility, and dissolution. Crystallo-co-agglomeration is a unique approach in which the pharmaceuticals or excipients are crystallized and agglomerated concurrently from a good solvent and/or bridging liquid by adding a non-solvent. The present study aims to formulate crystallo-co-agglomerates of Favipiravir to improve its physicochemical and mechanical properties. Results obtained during the evaluation showed that CCA technique could be successfully employed as an alternative to conventional wet...
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