Posted by admin on Oct 1, 2014 in |
Gefitinib is an epidermal growth factor receptor tyrosine kinase inhibitor, a promising anticancer agent for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC), especially in EGFR mutated patients. It acts by interfering with the proliferation and survival of cancer cells and other host-dependent process promoting cancer cell growth by blocking signal transduction pathways. The major advantage of Gefitinib over standard chemotherapy is that it selectively inhibits cellular pathways involved in tumor survival with minimal effect on normal cells. Gefitinib was the first agent to be tested in clinical trials among tyrosine kinase inhibitors class of anticancer drugs. Gefitinib is a very slightly soluble novel anticancer drug whose solubility and dissolution can be improved by its complexation with cyclodextrins. Gefitinib is a generally well-tolerated treatment, with skin rash and diarrhea being the most common treatment adverse effects. Gefitinib has the potential of stimulating cell immunity against malignant cells. Binding of Gefitinib to human plasma protein is extensive. This article reviews the safety and efficacy of Gefitinib...
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Posted by admin on Oct 1, 2014 in |
Chronotherapy involves the release of drug to the systemic circulation based on the circadian rhythm associated with the pathophysiology of a disease. Candesartan Cilexetil, an anti-hypertensive drug, is formulated to contribute to the chronotherapy of hypertension. Solubility study of the drug (BCS Class II) in various media indicated maximum solubility in pH 6.8 sodium phosphate buffer containing 1% SLS. Solid dispersion of Candesartan Cilexetil with PVP K30 was prepared by melt dispersion. Core tablet containing solid dispersion equivalent to 16mg Candesartan Cilexetil was prepared by direct compression. The % dissolution efficiency (DE60) of the pure drug was 31.05% and increased for the solid dispersion to 56%. Compression coating was applied to this core tablet by direct compression using release rate retardants HPMC K15M and Eudragit S100 in various proportions to give timed-release. In-vitro drug release test carried out in 0.1 N HCl for the first 2 h and pH 6.8 buffer containing 1% SLS for next 8 hrs showed formulation F4 containing 75 % of HPMC K15M and 25%...
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Posted by admin on Oct 1, 2014 in |
Cancer is a very complex genetic disorder that is mainly caused by carcinogens. Carcinogens can be present in the air, water, food, chemicals, and sunlight that are exposed to the people. In the case of leukemia, the body produces large numbers of abnormal white blood cells. In the study of blood cancer that is leukemia, blood disorders through visual inspection of microscopic images of blood cells is an important diagnostic tool. From the identification of blood disorders, it can lead to the classification of certain diseases related to blood. Doxorubicin drug most useful for cancer treatment such as Breast cancer, ovarian cancer, Lung cancer, Neuroblastoma cancer, Leukemia, etc. In breast cancer, the efficacy of drug treatment will thus depend on the histology of the tumor tissue. In ovarian cancer, the doxorubicin metabolites accumulated in the ascites and cleared more slowly from the peritoneal compartment than from the serum. Accumulation in the peritoneal cavity with prolonged half-life should be considered when administering medication in patients with ascites. In lungs cancer,...
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Posted by admin on Oct 1, 2014 in |
Plants have played an important role as various medicinal agents since ages. Medicinal herbs have been used in one form or another, under indigenous systems of medicine like Ayurveda, Siddha, and Unani. The knowledge of Indian medicinal plants and their uses in the Ayurvedic and Unani system of medicine have led to many scientific investigations and researches throughout the world. Asthma is a common disease that is rising in prevalence worldwide with the highest prevalence in industrialized countries. Asthma affects about 155 million people worldwide, and it has been estimated that is further 100 million will be affected by 2025. It has affected 14-15 million people in the United States, including an estimated 4.8 million childhoods. It accounts for about 11 million hospital visits annually and the sixth most frequent reason for visits in the ambulatory setting. It the past decade’s research has been focused on scientific evaluation of traditional drugs of plant origin for the treatment of various diseases. Since the time immemorial, various herbs are used as...
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Posted by admin on Oct 1, 2014 in |
The present study investigated the antioxidant and antiproliferative efficacy of Andrographis paniculata, a well-known medicinal plant, using in-vitro systems. The dried leaves of A. paniculata were powdered and subjected to successive solvent extraction taking from polar to non-polar solvents (descending polarity) and simultaneously from non-polar to polar solvents (ascending polarity). Solvents used for extraction were hexane, chloroform, ethyl acetate, acetone, methanol, and water. All the extracts were screened for the presence or absence of various secondary metabolites. The antioxidant activity of all extracts at 100 μg/ml was evaluated by DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. Further DPPH assay and reducing power assay were used to check the free radical scavenging capacity of methanolic and water extracts at their lower concentrations. The methanolic and water extracts of A. paniculata exhibited maximum DPPH inhibition of 20.75% and 17.71% respectively, at 100 μg/ml. A positive correlation between reducing power and concentration was found. Thin Layer Chromatography (TLC) of methanolic and water extracts of A. paniculata was performed. The antiproliferative effect of different concentrations of methanolic...
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