Posted by admin on Oct 1, 2014 in |
Herbal fungicides are gaining great interest because of their cost-effective and eco-friendly attributes. If this antifungal potency resides in weeds, it will be a great advantage because of their large population and to effectively develop a novel drug from weeds being considered as waste material. The present study aims to assess the anti-aspergillus activity of a common weed Lantana camara. The crude extract of leaves was obtained using polar and non- polar solvents and tested against Aspergillus niger ATCC 16888. Results reveal, the aqueous extract showed maximum growth inhibition of 14 ± 0.142 mm zone at 30 mg/ml, and it was 37 ± 0.124 mm for the standard antifungal agent voriconazole at 30 mg/disc. Further, the minimum inhibitory concentration of the extract was calculated as 18 mg/ml. Experiments on the mode of action suggested that the extract lyse the cells and alter the membrane integrity by depleting the ergosterol content, which avoids the...
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Posted by admin on Oct 1, 2014 in |
Hypertension is one of the most important public health problems globally. If the blood pressure is effectively controlled, many of the disastrous complications of hypertension such as myocardial infarction, stroke, kidney failure, heart failure, and death can be prevented or delayed. Patients usually attend the family physicians first for any illness they are suffering, including hypertension. Hence, family physicians who are primary care providers play a major role in the management of hypertension. A survey based on a validated questionnaire was conducted among primary care physicians of Puducherry to assess their current knowledge regarding investigations and pharmacotherapy of hypertension and associated comorbid diseases. Eighty, one primary care physicians, responded. Though, more than 53% of primary care physician favored fundus examination, lipid profile and electrocardiogram as essential investigations, urine for microalbuminuria was favored only by 11.11% of physicians. It is noteworthy that more than 82% of primary care physicians are aware that methyldopa should be the drug of choice for pregnancy-induced hypertension. However, more than 76% of primary care physicians...
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Posted by admin on Oct 1, 2014 in |
Ayurvedic Medicine originated in India more than 2000 years ago and relied heavily on herbal medicine products. Approximately 80% of India’s 1 billion populations use Ayurveda through more than one-half million Ayurvedic practitioners working in 2860 Ayurvedic hospitals and 22100 clinics. Ayurveda’s popularity in Western countries has increased. There are several reports of adverse effects of these herbal preparations due to the presence of high level of heavy metals such as Lead, cadmium, arsenic, and mercury and this problem has become a matter of concern. The present study was done to check the presence of lead, cadmium, arsenic, and mercury in five major ingredients Ajwain (Trachyspermum copticum), Ginger (Zingiber officinale), Neem tree (Azadirachta Indica L.), Peppermint (Mentha piperita), Turmeric (Curcuma longa) are the most essential and regular used materials for preparation of herbal medicines. These ingredients were procured from different location of Delhi, India, and subjected to analysis by Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) and Atomic Absorption spectrometer-Vapor Generation Assembly (AAS-VGA). Results were compared with the permissible limits...
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Posted by admin on Oct 1, 2014 in |
The presence of an excess amount of pharmaceutical impurities in active pharmaceutical ingredients and control of these are a major issue for all pharmaceutical companies. It is essential to know the presence of impurities in the drug substances and control them up to a certain level to avoid adverse effects. Impurities in organic drug molecules can be developed during organic synthesis, formulation or upon aging of active pharmaceutical ingredients, which may affect the quality, safety, and efficacy of drugs. Impurity profile is defined as the description of identified and unidentified impurities present in new drugs as per ICH guidelines. The identification of the impurities of different drugs is done by a variety of available Chromatographic and Spectroscopic techniques. The different analytical methods are utilized for characterization and identification of impurities such as Capillary Electrophoresis (CE), Gas Chromatography (GC), Supercritical Fluid Chromatography (SFC), Thin Layer Chromatography (TLC), High Performance Thin Layer Chromatography (HPTLC), High Performance Liquid Chromatography (HPLC), UV-Visible, IR, Mass, NMR and Raman spectroscopy. In this review article, a...
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Posted by admin on Oct 1, 2014 in |
Present study aimed to evaluate the nociceptive, neuro-muscular coordination, electrophysiological, biochemical, and histological features of diabetic neuropathy in streptozotocin-induced diabetic rats and the protective effects of Coccinia grandis leaf methanolic extract. Coccinia grandis (200 mg/kg per day) was given to diabetic rats for 3 weeks. Metformin (150 mg/kg body weight) was used as standard reference drug. Coccinia grandis showed its protection against allodynia test. NCV was also attenuated by treatment of Coccinia. The significant decrease in AR shows its protection against diabetic complications. Histological alterations induced by diabetes in the sciatic nerve were restored with Coccinia grandis leaf extract treatment. These results suggest that Coccinia grandis has attenuated progression of diabetic neuropathy in STZ-induced diabetic...
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