Posted by admin on Sep 1, 2014 in |
Swertia chirayita (SC) has been traditionally used for the treatment of several metabolic disorders related to health problems. We have investigated the antidyslipidemic and antioxidant potential of Swertia chirayita (SC) plant, a potent antidiabetic, and its isolated markers. The LC-ESI-MS standardized hot water extracts of different batches from the whole plant of Swertia chirayita, were tested in-vivo for their antidyslipidemic activity in Triton (WR-1339) and high-fat diet (HFD) induced dyslipidemic Charles Foster rats and in vitro for their antioxidant activity. Further solvent fractionation and isolation resulted in the identification of antidyslipidemic Mangiferin (MG) and Amarogentin (AM). Treatment of hyperlipidemic rats with MG and AM at 100 and 200mg/kg doses caused reduction in plasma levels of Low density lipoprotein (LDL) 24, 26% and very low – density lipoprotein (VLDL) 19, 25% as well as increase in levels of High density lipoprotein (HDL) 18, 22% respectively. In rats with HFD, MG and AM significantly reduced levels of VLDL lipids (26% and 27%) as well as Low-density lipoprotein-Total cholesterol (LDL-TC) 27% and...
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Posted by admin on Aug 31, 2014 in |
The present study was designed to evaluate the oculohypotensive effect of enalaprilat in comparison to timolol using an intraocular pressure (IOP) recovery model. The study was carried out in 18 adult albino rabbits of 2.5-3.0 kg which were divided into 3 groups.Group Ireceivednormal saline,group II received enalaprilat (0.1%) and timolol (0.5%) was administered in group III. IOP recovery model was used to assess the effect of drugs on IOP recovery time. Additionally relative percent of IOP (IOPt%) at various time intervals was calculated by equation: IOPt% = (IOPt / IOP-40) x 100 % . Condition of conjunctiva was also examined. There was a significant (p= 0.006) delay of the IOP recovery with both timolol (150 ± 8.65 minutes) and enalaprilat (130 ± 6.83 minutes) when compared to normal saline (110 ± 6.83 minutes). There was also a change in relative percent of IOP at all the time intervals being significant at 80 minutes (p=0.036), 100 (p=0.006) and at 120 minutes (p=0.032). There was no congestion of conjunctiva with both...
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Posted by admin on Aug 1, 2014 in |
Phragmanthera capitata is mistletoe (parasitic plant) that grows on other plants including avocado trees. Leaves infusion or decoction is claimed to treat amongst other ailments abdominal pains by herbalists in Cameroon. Our goal was to evaluate possible secretory, gastro and ulcer activities of aqueous extract of P. capitata (AEPC) in indomathacin induced gastric ulcer and pylorus ligation induced gastric ulcer (PLIGU) in albino rats. Preliminary phytochemical and toxicity assays were performed following standard procedures. To evaluate indomethacin induced gastric ulcer, control group received 10 ml/kg normal saline, standard group received 100 mg/kg cimetidine, test groups received AEPC (100, 200 and 300 mg/kg). To evaluate PLIGU, treatment was same as indomethacin induced ulcer. Data obtained were analyzed using analysis of variance (ANOVA) with Tukey test used as post hoc. In preliminary phytochemical assays AEPC revealed the presence of terpenoids, tannins, saponins, glycosides, anthraquinones, flavonoids, alkaloids and phenols. In acute oral toxicity assay, AEPC was safe up to a concentration of 3000 mg/kg in mice. In anti-ulcer evaluation AEPC decreased significantly...
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Posted by admin on Aug 1, 2014 in |
Aim: Plants have been used for medicinal purposes for more than many centuries. The use of a given plant for the same purpose by people geographically distant or with dissimilar cultural backgrounds constitutes impressive evidences that the use is valid. The aim of this study was to document ethnopharmacology of medicinal plants in Agaro District, Jimma Zone, South West Ethiopia. Methods: A cross–sectional study was conducted in the district from June 01-July 31, 2013. A structured questionnaire was used to record pertinent information on the use of the medicinal plants and collect their specimens. The study involved 440 households living in the district. Result: Eighty medicinal plants were collected, of which sixty–eight were identified botanically and the remaining were reported in vernacular names. The identified species were distributed in thirty–eight families. Leaves were the major plant parts used accounting for 42(44.7%), followed by roots 21(22.3%), fruits 17(18.1%) and barks 7(7.4%). Regarding the method of preparation, vegetable drug was the most commonly used method accounting for 30(37.5%), followed by decoction...
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Posted by admin on Aug 1, 2014 in |
The field of cancer research has been emerged in recent years for the development of specific drugs to cancer treatment. New agents with the ability to provide efficient treatment by reducing side effects has led to new opportunities for improving agents for cytotoxic therapies. While there are several drugs for colon cancer treatment, researchers are trying to evaluate new agents or combinations of existing ones which can be used efficiently. Schiff bases with a wide range of variety and biological properties including anticancer activity might be used for colon cancer treatment. In the current study, a novel schiff base derivative synthesized by our group was tested in vivo for colon cancer. In a model of azoxymethane (AOM) induced colorectal cancer, chemopreventive properties of schiff base was also analyzed in rats. While AOM induced de novo crypt formation, adenocarcinoma and dysplasia development, schiff base application reduced the number of aberrant crypt foci (ACF), dysplasia or adenocarcinoma. Analysis of the intestinal mucosa showed that peritoneal administration of SB complex not only...
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