Posted by admin on Aug 31, 2020 in |
Multidrug-resistant (MDR) bacterial infection is severe health concerns in the field of medicine. The researcher used green synthesized silver nanoparticles to overcome from MDR bacterial infection. Present study revealed successful synthesis of nanoparticles from Curcuma caesia aqueous rhizome extract by use of silver metal as a capping agent. Synthesized silver nanoparticles were identified by various methods like UV-Vis spectroscopy, Transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and Scanning electron microscope (SEM). Silver nanoparticles having an average size of 31.92 ± 2.8 nm by TEM. The synthesized silver nanoparticles were discovered as an effective source of nanomedicine against MDR strains of Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa. The antibacterial activity of nanoparticles measured in the range from 11.4 ± 0.83 mm to 17.73 ± 0.91 mm. The highest zone of inhibition was reported against Pseudomonas aeruginosa i.e., 17.73 ± 0.91 mm at a concentration of 30 μg/μl. Silver nanoparticles showed increased total phenolic and total flavonoid content, additionally with higher DPPH activity as compared to the aqueous rhizome extract. Present...
Read More
Posted by admin on Jul 31, 2020 in |
The purpose of current research work has been made to formulate a gastro-retentive drug delivery system (GRDDS) of those drugs having a narrow absorption window or having good absorption at the proximal part of the gastrointestinal tract (GIT) to deliver at stomach site and to improve the bioavailability of a drug. Gastro-retentive hydrogel tablet of Cefixime trihydrate was prepared by the direct compression method via using carbopol 940 and chitosan with different concentrations. Cefixime is a very poorly water-soluble drug after its oral administration so that it is slowly and incompletely absorbed from the gastrointestinal tract, which results within poor bioavailability i.e., 40-50%. Hydrogel was characterized concerning diverse parameters with mechanical strength, swelling ratio, in-vitro drug release, etc. The drug release from a combination of carbopol 940 and chitosan-based hydrogel showed for a prolonged period. A 32 full factorial design was utilized to optimize the tablet of cefixime trihydrate by selecting an amount of carbopol 940 and chitosan as independent variables and effects were observed on drug release and...
Read More
Posted by admin on Jul 31, 2020 in |
Herbal drugs have gained more importance and popularity in recent years because of their safety, efficacy, and low cost. The pteridophytes have an important role in folklore medicine, although neglected in modern days. These plants have been successfully used in different systems of medicines like Ayurvedic, Unani, Homeopathic, and other systems of medicines. Antimicrobial drugs are the greatest contribution of the present century to therapeutics. Dryopteris cochleata, family Dryopteridaceae which is popularly called as Jatashankari exhibits various therapeutic values to treat many diseases such as, epilepsy, leprosy, wounds, ulcers, diabetes, etc. was selected for the present research work to screen for antibacterial properties. The antimicrobial activity of ethanolic extract of Dryopteris cochleata was screened against two gram-positive bacteria (B. subtilis, S. mutans) and three-gram negative bacteria (E. coli, P. aeruginosa, K. pneumonia) and antifungal activity against Candida albicans and Aspergillus flavus by disc diffusion method. The extract showed significant antimicrobial activity against B. subtilis, S. mutans, E. coli, P. aeruginosa, Candida albicans but did not show antimicrobial activity towards...
Read More
Posted by admin on Jul 31, 2020 in |
In the study, we have successfully synthesized N-3 substituted tetrahydroquinazolinone by the reaction of isotonic anhydride with aniline derivatives. Thereafter novel derivative would be subjected to synthesize (1, 2, 3, 4-tetrahydroquinazoline) by Mannich reaction with ciprofloxacin and norfloxacin. These synthesized compounds (2a, 2b, 2c, 2d, 2e, 2f, 2g, and 2h) were characterized by FT-IR, 1H NMR, MASS spectroscopy, and elemental analysis and evaluated for their in-vitro antimicrobial activity and anti-inflammatory activity. The antimicrobial activities of synthesized compounds were evaluated against gram-positive and gram-negative bacteria. Amongst these tested compounds 2c, 2d, 2e, 2f exhibited potent antimicrobial activity than the rest of the compounds. All the synthesized compounds were screened for their anti-inflammatory activity using the carrageenan-induced rat paw edema model and exhibited protection against carrageenan-induced...
Read More
Posted by admin on Jul 31, 2020 in |
The application of nanobiotechnology is an emerging area of nanoscience and nanotechnology. In the present studies, tungsten nanoparticles were synthesized and reduced chemically, and character-rization was done by UV, SEM, TEM, FT-IR, and XRD. The size of nanoparticles was found to be 20 nm. Further, these nanoparticles were teste for various biological applications. In antimicrobial activity, it was observed that potent efficacy was observed against Streptomyces grisveus (12 mm) at 80 µg/ml while in fungus maximum activity was observed against Penicillium funicolusum (24 mm) at the same dose. The antiplatelet activity of nanoparticles was investigated by Prothrombin (PT) and Activated Partial Thromboplastin Time (APTT). In both PT and APTT assay, maximum activity was observed at 40 µg/ml (295 sec and 80 sec, respectively). Cytotoxicity was also studied by MTT assay against various cell lines. Against MCF-7, potent activity was observed at 200 µg/ml, while in 3T3 it was observed at 500 µg/ml. Finally, it was observed that these nanoparticles have potent activity against tuberculosis at 1000 µg/ml. The result...
Read More
