Posted by admin on Mar 31, 2016 in |
In the present paper QSAR studies related to some novel substituted pyrazole derivatives are reported. All the compounds were evaluated for antmicrobial activity viz- antifungal activity against A. niger. Their reported antimicrobial activities were used for Quantitative Structure Activity Relationship (QSAR) studies to find correlation between different calculated molecular descriptor of the compounds and biological activity. It is reported that five compounds viz. A-2, A-6, A-7, A-10 and A-11 showed maximum activity against A....
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Posted by admin on Mar 31, 2016 in |
Kamdhenu or Indian cow (Bos indicus) is worshipped as sacred animal by Hindus. The reason for worshipping is the tremendous therapeutic values of cow derived products like cow milk, cow milk curd, cow butter (ghee), cow urine, cow dung and a combination formulation Panchgavya. The use of these products has been well defined in ancient Ayurvedic texts like Charak samhita, Shushruta samhita, Brahad-Wagbhatt etc. Cow ghee showed anticancer and hepatoprotective potential by altering the enzymatic activities whereas cow urine acts by an unknown mechanism. Analgesic activity is attributed to presence of steroidal moieties and volatile fatty components in it. Antioxidants isolated from cow urine are responsible for antidiabetic, immunomodulatory, antiepileptic, antibacterial, antifungal and antimicrobial activities. Cow ghee contains a number of saturated and unsaturated fatty acids that plays active roles in production of inflammatory mediators and wound healing processes. This study is to gather the scientific research findings to support the traditional uses of cow derived products and to create research interest in...
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Posted by admin on Mar 31, 2016 in |
Calotropis gigantea L. flowers were widely used as a natural herbal medication. The objective of the present study was to screen the phytoconstituents and to evaluate the antibacterial and anti-cancer properties of Calotropis gigantea flower extract. The UV-Vis and FTIR spectroscopic techniques were employed to screen the phytochemicals. The antibacterial property of the extract was evaluated through serial broth dilution technique. Cell viability was performed using MTT assay on HeLa cell lines. The presence of Phenolic compounds was confirmed by UV-Vis peak at 271nm. IR spectrum confirms the presence of alcohol/phenols, primary amines, aldehydes, alkanes, alkenes, sulfoxide and halogen compounds. The extract showed antibacterial activity against Enterococcus faecalis (75µg/ml) and Klebsiella pneumonia (2µg/ml). The aqueous ethanolic extract of Calotropis gigantea flower exhibited less activity on HeLa cancer cell viability even at higher concentrations (1000µg/ml). The application of spectroscopic techniques promises to be of a great value in screening phytoconstituents of the extract because of their simplicity and cost-effectiveness. The extract is capable of inhibiting the bacterial growth and may...
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Posted by admin on Mar 31, 2016 in |
In recent years heterocyclic compounds analogues and derivatives have attracted wide attention due to their useful biological and pharmacological properties. Benzothiazole is a privileged bicyclic ring system with diverse applications. The small and simple benzothiazole nucleus is present in compounds involved in research aimed at evaluating new products that possess biological activities, such as anticancer, antimicrobial, and antidiabetic, anticonvulsant, anti-inflammatory, antiviral, ant tubercular activities. These compounds have special significance in the field of medicinal chemistry due to their remarkable pharmacological potentialities. This review is mainly focus on the research work reported in the recent scientific literature on different biological activities of benzothiazole...
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Posted by admin on Mar 31, 2016 in |
The present work aims to examine the antimicrobial activity of three medicinal plant extracts grown in Saudi Arabia namely Pulicaria crispa, Achillea fragrantissima and Cleome Africana against 10 clinical isolates of multi-drug resistant bacteria (MDR) that belong to four species, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumonia. The antibacterial potential of the methanolic plant extracts was assessed by the agar well diffusion method and expressed in terms of diameters of inhibition zone. The outcomes of these experiments indicated that each extract has shown an activity against four resistant isolates at least, with maximum zone of inhibition 19 mm recorded by P. crispa extract against S.aureusstrain (1). As a new finding, it was observed that C. Africana extract has bioactivity as antibacterial agent against maximum number of resistant isolates (seven out of ten tested strains) including all tested isolates of S.aureus (ranged between 7 and 14 mm). Methanolic extract of A. fragrantissima demonstrated two considerable growth inhibition against one isolate of both S.aureus and Ps. aeruginosa. The chemical...
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