Posted by admin on Sep 1, 2010 in |
Medicinal plants are important source of potentially useful structures for the development of novel chemotherapeutic agents. The present study was aimed to evaluate the antifungal effect of partially purified C. gigantea latex extract on some human pathogenic fungi. Ethanolic extract of the latex were tested in vitro against fungi strains. The inhibitory effect was assessed by disc diffusion method. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were also determined by serial dilution method. The ethanolic extract was subjected to qualitative phytochemical screening for the presence of bioactive ingredients. The ethanolic extract shows the presence of many biologically active molecules such as flavonoids, alkaloids, triterpenoids, steroids, saponins, phenols and glycosides. The latex extract shows significant zone of inhibition in dose dependent manner. The MIC and MFC values of latex extract against fungal strains varies from 1 mg to 8 mg and the results are comparable with Amphotericin B. From this study, we conclude that the latex extract possesses potent fungicidal activity which may be due to the...
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Posted by admin on Sep 1, 2010 in |
Synthesis of some aldehyde derivatives of 1, 4 di- hydro pyridine has been done. The entire synthesized compounds were characterized by UV, IR and 1HNMR spectroscopy. The anticonvulsant and antimicrobial activity were also evaluated. The present investigation deals with the synthesized compounds possessing good anticonvulsant, analgesic and antimicrobial activity. Synthesized compounds like PNH, PNA, ONF, MND, PAH posses significant anti convulsant activity. However, all the compounds showed analgesic activity less than the reference standard. Anti bacterial activities of the compounds were evaluated against staphylococcus aureus and the zone of inhibition was measured as the parameter of activity. Amikacin, the standard showed a zone of inhibition of 18 mm out of 8 synthesized compounds only one PNN (Ia) compound showed an equal activity when compared with standard. In which (ONF, PAN) showed considerable anti bacterial activity. The remaining four compounds PNM, MNC, MNA, PAK showed moderate antibacterial activity. Anti bacterial activity of the compounds were evaluated against E. Coli and the zone of inhibition was measured as the parameter of...
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Posted by admin on Sep 4, 2008 in Blog |
Antimicrobial resistance has been called one of the world’s most pressing public health problems. Addressing the issue of antimicrobial resistance is one of the most urgent priorities in the fields of public health today. Alarmingly, the development of resistance such as multi-drug resistance towards a number of antibiotics poses a challenge to the scientific community in the discovery of new therapies. Thus, there is a need to develop newer and effective molecules with high safety profile. Benzothiazoles are fused membered rings, which contain heterocycles bearing thiazole. Sulphur and nitrogen atoms constitute the core structure of thiazole and many pharmacologically and biologically active compounds. Benzothiazole is an interesting pharmacophore exhibiting diverse pharmacological activities like antimicrobial, anticancer, anthelminthic, antidiabetic, antitubercular, anticonvulsant, antioxidant, anti-inflammatory, antifungal, antipsychotic etc. The present article extensively covers various procedures of synthesis of 2-substituted benzothiazole core and its analogs – by utilizing distinctive catalysts, solvent conditions, reactants immobilized on solid support and microwave irradiation. Variations in synthetic procedures are studied to explore chemo-selectivity of the reactions, in-expensive, eco-friendly,...
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Posted by admin on Jun 1, 0203 in |
Objective: The aim of the present study is to investigate the synthesis and characterization of Silver nanoparticles (AgNPs), and their antimicrobial effect on gram positive and gram negative bacteria by using hydro alcoholic leaf extract of Ipomoea Aquatica Forsk (HAEIA). Material and Methods: AgNPs were prepared by green synthesis process from 1mM AgNO3 solution the aqueous silver ions when exposed to the HAEIA were reduced and stabilized over long periods of time resulting in the green synthesis of surface functionalized silver nanoparticles. The bio-reduced silver nanoparticles were appropriately characterized by using UV-Vis spectroscopy, Particle size distribution and Zeta potential. Antibacterial activity of synthesized silver nanoparticles (AgNPs) was carried out on both Gram negative and Gram positive bacteria and compared with standard antibiotic Ciprofloxacin. Result: The particle size of bio synthesized silver nanoparticles is found to be in the range of 77 – 624 nm with polydispersity index (PDI) of 0.207 clearly indicates that the particles are in very narrow size distribution. The zeta potential value of -6.16 mV that...
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