Posted by admin on Aug 1, 2010 in |
A series of 3- (5- substituted phenyl- 1, 3, 4- Oxadiazol- 2- yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IVb, and IVe exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compound C exhibited antibacterial activity against Staphylococcus aureus and very poor activity against rest of organism. Compounds IVa, IVb and IVe showed poor antifungal activity against Candida albicans and compounds IVc and IVd showed no significant antifungal activity. The interesting antimicrobial profile of compound IVb and IVe led us to select this derivative for further development. Present research our expected compounds were given below....
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Posted by admin on Aug 1, 2010 in |
Novel 2- Aminothiazole derivatives were synthesized by the reaction of 2-aminothiazole (1) with chloroacetylchloride in presence of K2CO3 in chloroform afforded 2- chloro- N- (thiazol – 2- yl) acetamide (2). Compound (2) on condensation with substituted phenols in presence of K2CO3 in acetone afforded the title compound (3a-g). The chemical structures of the synthesized compounds were elucidated on the basis of IR, 1H NMR data. The synthesized compounds were screened for antibacterial and antifungal activity among them the compound 3c and 3d have shown significant inhibition of bacterial and fungal growth....
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Posted by admin on Jun 1, 2010 in |
Reaction of 1- (1- benzyl- 1H- benzo [d] imidazol- 2- yl) hydrazine (1) with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehydes (2a-f) in ethanol yielded the corresponding Schiff bases (3a-f). Further, cyclization of compounds 3a- f with thioglycollic acid in benzene in presence of anhydrous ZnCl2 furnished desired novel compounds 3- (1 – Benzyl – 1h – Benzo [D] Imidazol – 2 – L Amino) – 2 – (3 – Aryl – 1- Phenyl – 1h – Pyrazol – 4 – Yl) Thiazolidin – 4- Ones (4a- f) in 41-65% yield. All the synthesized compounds were screened for antibacterial and antifungal activities. Among the synthesized compounds 3b, 3d, 4a and 4f have shown good activity against bacteria P. aeruginosa, S. aureus and P. vulgaris, where as other compounds have shown moderate to poor activity against all the organisms. The compounds 3a and 3c exhibited good activity against fungal strains A. niger and A. flavus. All remaining synthesized compounds exhibited moderate to poor activity against all the organisms. The structures of synthesized compounds have been established...
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Posted by admin on Feb 1, 2010 in |
The antimicrobial activities of aqueous, ethanolic and petroleum ether extracts of the leaves of Basella rubra were evaluated in the present study by measuring the inhibition zones using Cup Plate Diffusion method. The inhibition zones were significantly different (P<0.001) in each plant extract. The ethanolic extract showed maximum activity with zone of inhibition (14.3±1.82 mm) against E.coli, followed by aqueous extract (13.4±1.2 mm) and petroleum ether (5.6±0.62 mm) at a concentration of 50g/ml. Ciprofloxacin was used as the standard drug having zones of inhibition(17±0.34 mm) against E.coli and 19±0.18 mm against A. niger. Microbial inhibition was in the order E.coli (12.57±0.99), A. niger (11.68±0.71), V. cholera (11.42±0.60), S. aureus (10.71±0.46), S. typhi (9.80±0.90) , respectively with all the extracts. The extracts were not able to inhibit the growth of P....
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Posted by admin on Jan 31, 2026 in |
The present study explored the phytochemical makeup, antioxidant potential, and chemical profile of three important Ficus species viz. Ficus hispida, Ficus semicordata, and Ficus racemosa. The goal of this study was to investigate the therapeutic potential of these species. Quantitative phytochemical analysis revealed notable levels of total phenolics, flavonoids, and tannins in all the species, with variations among the species contributing to the differences observed. An antioxidant activity study, including DPPH and ABTS radical scavenging, revealed strong antioxidant potential, closely linked to the phenolic and flavonoid contents, highlighting the ability of these compounds to quench free radicals. Gas chromatography–mass spectrometry (GC–MS) profiling revealed a wide range of bioactive compounds, such as fatty acids and their esters, terpenoids, long-chain hydrocarbons, glycosides, and phthalate derivatives. Key compounds such as n-hexadecanoic acid, oleic acid derivatives, phytol, squalene, and various alkyl esters were found. Many of these compounds are linked to antioxidant, anti-inflammatory, antimicrobial, and cholesterol-lowering effects. Differences in chemical profiles among the species offer insights into their unique medicinal uses. Overall, the...
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