Lantana camara Linn. is considered as a notorious weed and a popular ornamental plant. It is noted from ancient time that plants have been an excellent source of medicine. Since very long time Lantana camara has been reported as one of the most important medicinal plants in the world. Lantana camara is used in traditional medicine system for the treatment of cuts, swellings, ulcers, cataract, bili...
Vitex negundo, commonly called Nirgundi, is one of the widely investigated medicinal plants of India. The present study were planned to compare different parts, i.e. leaves, stems and roots of V. negundo for antianxiety activity using elevated plus maze model. Petroleum ether (60 - 80 °C), chloroform, ethanol and aqueous extracts of these parts were prepared and evaluated for anti-anxiety activit...
BISPHENOL A ENHANCES GROWTH OF Hep-G2 CANCER CELLS BY UPREGULATING EXPRESSION OF PRO – INFLAMMATORY AND PRO – ANGIOGENESIS PROTEINS
Bisphenol A (BPA) is primarily used in the manufacture of plastics and resins. There are many scientific reports that point to the adverse effects of this chemical to different animal models. There has been an increase in use of plastic during the last couple of decades and this has increased human exposure to plasticizers like Bisphenol A. But since little is known on how these endocrine disrupto...
EFFECT OF FRESH JUICE OF KHAT (CATHA EDULIS) ON BLOOD GLUCOSE LEVELS OF NORMOGLYCEMIC AND STREPTOZOCIN-INDUCED DIABETIC RATS
Khat is chewed traditionally in Ethiopia, Somalia, Yemen and Kenya. In Ethiopia, khat chewing is now becoming an everyday substance of abuse for the general population. Knowledge about the effects of khat chewing on blood glucose levels is very sparse. Therefore, the objective of this study was to investigate the effect of fresh juice of khat (Catha edulis) on blood glucose levels of normal and st...
PHYTOCHEMICAL INVESTIGATION AND HEPATOPROTECTIVE EFFECT OF SCOPARIA DULCIS AGAINST CARBON TETRACHLORIDE INDUCED LIVER DAMAGE IN RATS
The objective of the present study is to carry out the photochemical investigation and hepatoprotective activity study of different extracts of Scoparia dulcis. Scoparia dulcis Linn. belongs to the family Scrophulariaceae and have ruminate medicinal properties. The different extracts of this plant were prepared by successive extraction with petroleum ether, chloroform and ethanol. These extracts (...
Osteoporosis is defined as low bone density with micro architectural deterioration of bone tissue leading to enhanced bone fragility and increased fracture risk. Knowing the treatment pattern of osteoporosis is imperative in achieving better health outcomes. Thus the purpose of our study was to assess the treatment pattern of osteoporosis in 8 different medical colleges and hospitals in Bangladesh...
KINETIC AND MECHANISTIC STUDIES ON OXIDATION OF DONEPEZIL HYDRO CHLORIDE BY CHLORAMINE – T IN BASIC MEDIUM
Donepezil hydrochloride is United States Food and Drug Administration (USFDA) approved drug marketed under the trade name “Aricept” used for the treatment of mild to moderate alzheimer disease. The aim of the current investigation was Kinetic and mechanistic study of donepezil hydrochloride by sodium-N-chloro-p-tolunesulfonamide or chloramine-T (CAT) in NaOH medium was studied at 308 K. the re...
STUDY OF CLINICAL AND HISTOPATHOLOGICAL PATTERN, SEVERITY, CAUSALITY AND COST ANALYSIS IN HOSPITALISED PATIENTS WITH CUTANEOUS ADVERSE DRUG REACTIONS IN A TERTIARY CARE HOSPITAL
Objectives: To assess clinical and histopathological patterns, causative drugs, causality, severity and cost of treating cutaneous adverse drug reactions (CADRs) among patients admitted in tertiary care teaching hospital. Methods: In a prospective hospital-based study over a period of one year (June 2015- June 2016), CADRs of patients admitted to the dermatology department were recorded. The data ...
In this paper, we investigate several topological indices in honeycomb graphs: Randić connectivity index, sum-connectivity index, atom-bond connectivity index, geometric-arithmetic index, First and Second Zagreb indices and Zagreb polynomials. Formulas for computing the above topological descriptors in honeycomb graphs are given....
A RAPID AND SENSITIVE LC-MS/MS ASSAY FOR THE DETERMINATION OF CLOBAZAM IN HUMAN PLASMA USING ELECTRO SPRAY IONIZATION TECHNOLOGY
A simple, highly sensitive, precise and accurate liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed for the rapid quantification of clobazam in human plasma samples. The chromatographic separation was achieved with a reverse phase column Reprosil Gold XBD C18 (100 × 3mm, 3µm) and the mobile phase consisted of 10 mM ammonium acetate buffer and 0.1% acetic acid in metha...