Ras proteins in association with GTP and GDP act as a bio-molecular switch for signaling cell growth, cell survival and signal transduction. The presence of mutated Ras proteins is found to vary in different cancer types and the highest occurrence of about 90% is observed in pancreatic cancer. The Ras GTPase binding site is mainly involved in signal cell proliferation. Hence, this binding site h...
Artemisia vulgaris leaves are known to have anectodatal evidence of antioxidant activity which can be of use as an anti – stress remedy. However, this claim is yet to be proven and no available data on its adaptogenic potential hence, this study aimed to determine the adaptogenic potential of Artemisia vulgaris leaf extract on male albino rats using acute restraint stress. Six male albino rats w...
Background: Kapikacchu (Mucuna pruriens (L.) DC.) belonging to the family Fabaceae is commonly known as Velvet bean, Cowitch, Cowhage in English and Kawaanch, Kavach in Hindi. It is mainly distributed in Asia, Africa, Pacific Islands and the United State. Kapikacchu is very famous plant for its aphrodisiac effect. Traditionally it is being used as a potent antiparkinsonian, anti-inflammatory, ap...
STANDADADIZATION AND STABILITY INDICATING STUDIES BY RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF CANDESARTAN CILEXETIL & HYDROCHLORTHIAZIDE IN TABLET DOSAGE FORM
A rapid, selective, precise, accurate, rugged and robust high performance liquid chrmatgraphic (HPLC) method for the simultaneous determination of Candesartan Cilexetil & Hydrochlorthiazide in tablet dosage form .The method was validated according to ICH and FDA guidelines. The chromatography is performed on a Kromasil C8, 150 x 4.6 mm, 5µm, in a gradient mode with a mobile phase of Water, ac...
FORMULATION AND EVALUATION OF ARCHIMEDES BASED NOVEL FLOATING CAPSULE THROUGH FILM FORMATION AND RETENTION FOR DRUG DELIVERY OF LEVOFLOXACIN
The study objectives were to develop a unique expandable integrated floating film to be filled in capsule dosage form, which combines hydrophilic and hydrophobic polymers. The developed film was totally free from the concept of gas generating system or the low-density system, which floats merely due to Archimedes principle. A 32 full factorial design was used in the study with HPMC K100M (X1) and ...
Two new potential allelochemicals were isolated from ethanolic extract of the aerial parts of Indigofera trifoliata Linn. Along with three known compounds Tricin (3), Taraxerol (4) and 5-hydroxy-3, 4′, 7-trimethoxyflavone (5). The structures of new allelochemicals were characterized as 6, 3′, 4′-trihydroxy-5, 7, 8-trimethoxyflavanone-4′-O-α-L-rhamnopyranosyl-(1→4)-O-β-D-xylopyranosyl...
PROTECTIVE EFFECT OF NYCTHANTHES ARBOR-TRISTIS ON SCOPOLAMINE INDUCED AMNESIA IN RATS “A BEHAVIOURAL AND BIOCHEMICAL APPROACH”
The hydroalcoholic extract of Nyctanthes arbor-tristis (HeNAT) leaf was prepared using Soxhlet apparatus. Memory impairment (amnesia) in male albino rats induced by scopolamine hydrochloride was recorded as transfer latency time (TLT) in EPM model; escape latency time (ELT) and time spent in Q4 target quadrant (TSTQ) in MWM model. Scopolamine markedly decreased the TLT over 2 min, ELT, TSTQ over 9...
SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY EVALUATION OF SOME NEW 2-(3-FLUOROBIPHENYL-4-YL) PROPANOIC ACID DERIVATIVES
Different new compounds derived from 2-(3-flourobiphenyl-4-yl) propanohydrazide  as starting material were synthesized. Reaction  with maleic anhydride, succinic anhydride and phthalic anhydride gave the corresponding cyclicimides [3a-c]. The hydrazone derivatives [4a-d] were obtained by condensation of compound  with 2,4-dimethoxybenzaldehyde, 4-(N,N-dimethylamino)benzaldehyde, 3-hydroxy...
Adverse drug reactions in the form of toxic epidermal necrolysis is a rare but potentially fatal disorder. The pathophysiology of such reactions are not properly understood. There are many drugs which are very often implicated for causing such severe reactions. Allopurinol is a common drug used in chronic gout but also notorious for causing Steven - Johnson syndrome and rarely toxic epidermal necr...
Phosphodiesterase PDE10A is an enzyme that has established connection earlier with schizophrenic condition, schizophrenia is well known severely chronic and disabling disease worldwide today. Unfortunately, there is no concrete evidence till day to point out as a single cause of this disease. However, in a recent work a research team of Merck Research Group recognized earlier pyp-1 as an effective...