Flavoxate Hydrochloride is an antispasmodic, mainly used for treating painful urination, urgency of urination and incontinence. The primary objective of the study was to formulate extended release capsules of Flavoxate hydrochloride to reduce dosing frequency and decreasing the associated side effects. The extended release capsules were formulated using extrusion spheronisation process with ethyl ...
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NOVEL 1- PHENYL 1-H-PYRAZOLO[3,4-D]PYRIMIDINE DERIVATIVES
Novel 1- Phenyl 1-H-Pyrazolo[3,4-d]Pyrimidine Derivatives were synthesized from the key intermediate chloro derivative (1).The conversion of chloro derivative(1) into 1,2,4 triazoles, 1,3,4 thiadiazoles and thiazoles was accomplished with the intermediacy of the ester(2) and hydrazide (3). Moreover triazole ring was annelated to the pyrazolopyrmidine core in two step reaction involving reaction wi...