Cancer - one of the most pervasive diseases, thus far mostly in affluent countries - is fast raising its ugly head in the developing world. This is a survey work on cancer due to recent increasing of the number of cancer patients in Bangladesh. This study was carried out in Ahsania Mission Cancer Hospital, Dhaka Bangladesh as this is the biggest missionary hospital in this country, From 13 Febru...
ANALGESIC ACTIVITY OF EXTRACTS OF EULOPHIA OCHREATA LINDL. AND ZINGIBER CASSUMUNAR ROXB. IN ANIMAL MODEL
The present study was designed to investigate Analgesic activity of Chloroform extract and isolate 1 of Eulophia ochreata Lindl. and dicholoromethanolic extract and isolate 2 of Zingiber cassumunar Roxb. The analgesic activity was assessed by using acetic acid induced writhing method and hot plate method. In acetic acid induced writhing method the extracts and isolates of both plants was administe...
EFFECTS OF ANTIMICROBIAL ACTIVITY OF VITIS VINIFERA (RED GRAPE) AND CAMELLIA SINENSIS (GREEN TEA) EXTRACTS
Food and nutrients play vital role in normal functioning of the body. The samples selected for this study were Ethanolic extract of Red grape seed, Ethanolic extract of green tea leaves, Commercially available grape seed extract / Isotretinion tablet, green tea extract , Vitamin A and E tablets. The Nutraceutical effects of grape seed extract and green tea extract was analyzed. The antimic...
DEVELOPMENT AND VALIDATION OF METHODS USING DERIVATIVE SPECTRO-PHOTOMETRY FOR DETERMINATION OF DIPYRONE IN PHARMACEUTICAL FORMULATIONS
Dipyrone (sodium noramidopyrine methanesulfate), a member of the pyrazolone group, is a drug that possesses analgesic, antipyretic, anti-inflammatory, and spasmolytic properties. Traditionally, iodimetric methods have been recommended for the quantitative determination of dipyrone in all its pharmaceutical forms. This work describes the development of zero order and fourth order (∆λ = 10) deriv...
A PHARMACIST BASED INTERVENTION TO IMPROVE THE CARE OF PATIENTS WITH HYPERTENSION AND DIABETES MELLITUS IN A PRIVATE INSTITUTION
The study was intended to evaluate the effectiveness of patient counselling in improving the quality of life (QOL) and knowledge, attitude and practices (KAP) of hypertensive and diabetic patients in a private educational institution. The study was conducted for a period of six months with the help of validated KAP and QOL questionnaire. Impact of patient counselling was studied by comparing the K...
The skin covers a total surface area of approximately 1.8 m2 and provides the contact between the human body and its external environment. Transdermal route of drug delivery has gained great interest in pharmaceutical research as it overcomes many problems associated with the oral route of administration. Although the skin, particularly the stratum corneum presents a barrier to most drug absorptio...
POLY (LACTIC-CO-GLYCOLIC ACID) BASED DOUBLE EMULSION NANOPARTICLE AS ACARRIER SYSTEM TO DELIVER GLUTATHIONE SUBLINGUALLY
The sublingual delivery of drugs represents a continuing challenge, as well as an opportunity. In this study, a poly (lactic-co-glycolic acid) (PLGA) based Water-in-Oil-in-Water (w/o/w) double emulsion of nanoparticles was developed as potential platform technology, to generate sustained drug release profile and maximize the bioavailability of the glutathione (GSH). Two-level full factorial design...
In the present study, an effort has been made to evaluate of hydroxypropyl methylcellulose HPMC K15M as rate retardant polymer to sustain the release of Tramadol HCl from Tramadol HCl sustained release tablet matrix. Different amount of HPMC K15M were used in formulation of F1 to F5 where drug and polymer ratio were consequently 5:6, 5:5, 5:4, 5:3 and 5:2 in 200 mg tablet matrix. Tablets were prep...
Felodipine is a poorly water soluble drug having 15% oral bioavailability. In the present study Self micro emulsifying drug delivery system of felodipine was developed to improve its solubility and bioavailability. SMEDDS were prepared by phase titration method and ternary phase diagram was constructed using Chemix software. Based on solubility of drug in the excipients, capmul MCM, oleic acid, Tw...
OXONE AND IODOBENZENE ARE USEFUL REACTION SYSTEM FOR SYNTHESIS OF 2-AMINOTHIAZOLE DERIVATIVES FROM EASILY AVAILABLE THIOUREA AND ALKYL / ARYL KETONES
A quick one step, innovative approach for the Synthesis of 2-aminothiazole derivatives from easily available thiourea and alkyl / aryl ketones with the help of Oxone and Iodobenzene reaction system has been developed in aqueous acetonitrile solution. The developed procedure is applicable to several types of substituted 2-aminothiazole derivatives to get the corresponding products. The developed me...