METHOD DEVELOPMENT AND VALIDATION OF SIMULTANEOUS DETERMINATION OF HYDROCHLOROTHIAZIDE AND LOSARTAN IN TABLET DOSAGE FORM BY RP-HPLC
Fixed-dose combinations have several advantages comparing with a single drug and separate agents. For simple dosing regimens and their synergistic antihypertensive action, a combination of hydrochlorothiazide and losartan potassium is widely prescribed. In this study, an HPLC-UV method was developed and validated for the simultaneous determination of hydrochlorothiazide and losartan in bulk and ph...
Enzymes are the protein molecule that acts as a catalyst for various biological reactions. The enzymes have a major role in designing the dose of the drug. Enzymes have a vital role as metabolizer of the xenobiotic. The activity or the mode of action of enzymes determines the bioavailability of drugs. The presystemic metabolism of the drug monitored by the gut wall and hepatic enzymes can...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF NEBIVOLOL AND VALSARTAN IN BULK AND DOSAGE FORM
The several spectrophotometric and HPLC methods have been reported for determination of Nebivolol and Valsartan individually or in combination with other drugs in pharmaceutical dosage forms. Hence, in the present study, a new, sensitive, suitable and cost-effective Reversed-Phase High-Performance Liquid Chromatography method was developed and validated for the determination of Nebivolol and Valsa...
Agriculture forms a vital part of India’s economy. More than 50% of India’s population is dependent on agriculture for their livelihood. In India, many crops are cultivated, out of which wheat is one of the most important food grains that this country cultivates and exports. Thus it can be seen that wheat forms a major part of the Indian agricultural system and India’s economy. Hence, the ma...
PRODUCTION OF XYLANASE BY PENICILLIUM SP. AND ITS BIOBLEACHING EFFICIENCY IN PAPER AND PULP INDUSTRY
The main objective of this study is to evaluate the ability of production of xylanase by a fungal strain Penicillium sp. isolated from decaying wood. Xylanases are hydrolytic enzymes produced by many microorganisms which catalyze the hydrolysis of xylan polymer to xylose monomer. The xylanase production was carried out under submerged fermentation xylose as the main substrate, and the enzyme yield...
Background: Plants and herbs consumed by humans are the rich sources of phytonutrients compounds synthesized in plants itself. Such bioactive substances are responsible for the plant’s antioxidant and medicinal values. Flavonoids are an essential group of naturally occurring polyphenolic compounds, and its flavan nucleus characterizes it. It is one of the most common classes of compounds availab...