EVALUATION OF MULTITARGETED ANTIPSYCHOTIC ACTIVITY OF UNMADGAJAKESARI – A HERBOMINERAL FORMULATION – AN ANIMAL EXPERIMENTAL STUDY
Schizophrenia is a chronic and complex mental disorder characterized by hallucinations and delusions that significantly affect emotions, behavior, and mental processes. Currently used antipsychotics are characterized by the multireceptor mode of action (antagonism of dopamine D2 and serotonin receptors), there is no consensus regarding an "ideal" target engagement. Moreover, they are associated wi...
THERAPEUTIC EFFECT OF BELLAMYA BENGALENSIS LAMARCK BY INHIBITION OF OXIDATIVE STRESS IN EXPERIMENTAL ARTHRITIC MODEL
Objective: Oxidative stress and generation of free radicals leads to several chronic inflammatory diseases like arthritis, diabetes mellitus, cancer, etc. Arthritis is an immune-mediated systemic disorder known to impair the quality of life. In spite of development of drug discovery, therapeutic targeting of arthritis is still not satisfactory. Bellamya bengalensis has been long known for used in ...
The purpose of the research was to assess the prescribing pattern in geriatrics and to analyze the prescription using World Health Organization (WHO) core prescribing indicators and American Geriatric Society (AGS) Beers criteria 2012 for potentially inappropriate medication use in older adults. This prospective drug utilization study was conducted for a period of 6-months. Patients of either gend...
Natural products have great potential against microbes and can be used to overcome the problem of drug resistant pathogens. They are helpful in reducing the toxicity of existing antifungal compounds. This present in vitro study demonstrated the synergistic effectiveness of Cassia fistula (CF) leaves extracts and fluconazole (Flu) against isolated Flu resistant strains (FRSs) of Candida albicans (C...
Green chemistry or sustainable chemistry focuses on designing products and processes that minimize the generation or use of hazardous substances. Green chemistry, though not a new area, has recently gained much importance because of increasing environmental concerns. Industries now focus on adopting processes which are mainly non- hazardous, easier to undertake, lesser energy and time consuming, ...
The objective of present study was to formulate and evaluate Tariquidar bimesylate subcutaneous in situ implants in order to minimize the frequency of doses and toxicity and to improve the therapeutic efficacy. The anthranilic acid derivative, tariquidar (XR9576), is a potent and selective P-gp inhibitor being developed clinically for the treatment of multidrug resistant tumors. Tariquidar bimesyl...
Background: Cisplatin is active cytotoxic agents in the treatment of cancer and has many adverse side effects, including hepatotoxicity. Honey and royal jelly are natural products and having antioxidants properties. Aim of the study: To investigate the protective role of combined administration of honey and royal jelly against cisplatin-induced changes in biomarkers of oxidative stress in rat live...
MOLECULAR DOCKING STUDIES OF A FEW NOVEL PYRIMIDINE DERIVATIVES AS REVERSE TRANSCRIPTASE HIV-1 INHIBITORS
Anti-HIV drug discovery has been increasingly focusing on HIV-1- reverse transcriptase as a potential therapeutic target. Pyrimidine-based derivatives are studied for their HIV-1 reverse transcriptase inhibition activities using in-silico techniques. The library of 19 pyrimidine-based derivatives designed using computer-based molecule designed software and docked with HIV-1 reverse transcriptase e...
ANTIDIARRHOEAL ACTIVITY OF LEAF EXTRACT OF ANOGEISSUS LATIFOLIA WALL IN EXPERIMENTALLY INDUCED DIARRHOEA IN RATS
Aim: To evaluate the antidiarrhoeal activity of methanolic leaf extract of Anogeissus latifolia. Material and Methods: The methanolic extract was evaluated using rodent animal models like castor-oil induced diarrhoea and castor-oil induced enteropooling. The phytochemical constituents were also planned to screen by using standardized methods. The plant is traditionally used for the treatment of...
COMPARISON OF THE TOXICOLOGICAL EFFECT OF LEAD-BASED HERBO-MINERAL PREPARATIONS AND THEIR CORRESPONDING METAL NANO-PARTICLE ON ENZYMATIC ACTIVITY AND GROWTH OF BAKER’S YEAST
Metallic toxicity associated with Ayurvedic formulations like herbomineral preparation (Bhasma), especially because of heavy metals such as lead, has always been a matter of debate in the scientific community. Instead of that, ancient Ayurvedic literature reveals that sodhana process used for the preparation of such formulations, either decreases or eliminate the toxic effect of such heavy metals ...