IMPACT OF NASAL CONTINUOUS POSITIVE AIRWAY PRESSURE ON C-REACTIVE PROTEIN IN OBSTRUCTIVE SLEEP APNEA PATIENTS
Obstructive sleep apnea (OSA) has been increasingly linked with cardiovascular risk factors. Mechanisms such as increased sympathetic activity and endothelial dysfunction have been implicated. There are many factors which are responsible for the cardiovascular morbidity in OSA patients they are Obesity, C-reactive protein (CRP) and lipid profile. To study the impact of nasal continuous positive ai...
ANTI-HYPERGLYCEMIC EFFECT OF CARALLUMA LASIANTHA EXTRACT ON HYPERGLYCEMIA INDUCED BY CAFETERIA-DIET IN EXPERIMENTAL MODEL
Caralluma lasiantha is a succulent plant belongs to Ascalpedaceae family. The objective of this study was to evaluate and to compare the anti-hyperglycemic effect of Caralluma lasiantha with Chromium Picolinate on hyperglycemia induced by Cafeteria-Diet in Wistar albino rats. Hyperglycemia was induced in experimental rats by feeding Cafeteria-Diet for a study period of 90 days. Caralluma lasiantha...
Tuberculosis (TB) is an ancient disease that has caused inestimable suffering and claimed millions of lives over the centuries. Resistant strains of Mycobacterium tuberculosis have slowly emerged especially in developing countries due to the lack of health care organisation in order to provide the long and costly treatment adapted to patients. In fact, 90% of all TB cases occur in the developing w...
Targeted genome engineering provides the ability to precisely modify genetic information in order to study gene function, biological mechanisms, and disease pathology. Historically, random mutagenesis or low-efficiency homologous recombination were used to modify the genomes of cell lines or animal models. However, new advances in the design of sequence-specific endonucleases have enabled more eff...
FORMULATION AND EVALUATION OF FLOATING MATRIX TABLETS OF METFORMIN HCl FOR THE TREATMENT OF TYPE-2 DIABETES MELLITUS
Floating matrix tablets of Metformin hydrochloride were developed and evaluated to increase bioavailability by increasing gastric residence time and sustained release of drug in the upper part of gastrointestinal tract thereby diminishing side effects and enhanced patient compliance. The tablets were formulated by using central composite design having two independent variables at three levels. Ind...
COMPARATIVE MODELING OF INACTIVE UBIQUITIN THIOESTERASE FAM105A AND MOLECULAR DOCKING STUDIES OF SYNTHESIZED BENZIMIDAZOLE DERIVATIVES
In this study, homology modeling and molecular docking studies were performed to explore structural features and binding mechanism of synthesized benzimidazole derivatives as ubiquitin inhibitors. A homology modeling procedure was employed to construct a 3D model of ubiquitin protein by using MODELLER9.15. For this procedure, the X-ray crystal structure of Gumby / fam105b in Complex with linear Di...
Prevalence and Co-infection of Cosavirus in Pediatric Patients with Acute Gastroenteritis from North India
Viral gastroenteritis is one of the major causes of childhood mortality in India. About 30 to 50 % gastroenteritis caused by unknown etiological agents. This study was aimed to identify unknown RNA viral etiology and their clinical manifestation with pediatric acute gastroenteritis, conducted at tertiary care hospital of Uttar Pradesh, North India from July 2012 to December 2013. A total of 234 pa...
THE REAL-WORLD STUDY OF SHENMAI INJECTION AND ITS ADVERSE REACTIONS ASSOCIATED TO PATIENTS IN CHINESE HOSPITALS: A PROSPECTIVE RESEARCH
Shenmai injection (SMI) is the Traditional Chinese Medicine Injection (TCMI) prepared by Red Ginseng and Radix Ophiopogonis extract. The aim of this study is to reveal the real-word of SMI, to evaluate its use and its adverse reactions associated to patients.A prospective, observational combined nested case-control clinical research carried out in two tertiary care teaching hospitals and two secon...
In contrast to the problematic health and economic effects of acute and chronic smoke exposure on lung function and airway inflammation, there are still few data dealing with the effects of smoking. Smoke exposurecan result in aberrant cell growth. In our experiments, pyrolyzed components of cigarettes have been shown to induce a strong stress response in cultured cells. We used human embryonic lu...
ROLE OF LABETALOL AND METHYLDOPA IN NEWLY DIAGNOSED MILD HYPERTENSION IN PREGNANCY: A PROSPECTIVE DRUG COMPARATIVE STUDY IN A RURAL TERTIARY CARE HOSPITAL IN INDIA
Aim: Labetalol is useful in severe hypertension (HT) in pregnancy; however, there was a need to define its role in mild HT in pregnancy. The present study was done to evaluate efficacy of labetalol in mild HT in pregnancy, compare it with that of methyldopa, and compare the tolerability of methyldopa and labetalol in patients. Methods: A prospective drug comparative study was conducted for one yea...