Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
MODULATION OF TUMOUR NECROSIS FACTOR Α ATTENUATES NALOXONE-PRECIPITATED OPIOID WITHDRAWAL SYNDROME
The present study has been designed to investigate the effect of modulation of tumour necrosis α (TNF-α) on naloxone induced opioid withdrawal syndrome. Chronic morphine (5mg/kg,i.p) administration followed by a single injection of naloxone (8mg/kg, i.p) was used to precipitate opioid withdrawal syndrome in mice. Behavioral observations were made immediately after naloxone treatment. Withdrawa...
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1518
SEROLOGICAL TESTING IN ASTHMA PATIENTS VISITING MAHAVIR HOSPITAL AND RESEARCH CENTRE
Background: The hypothalamic pituitary adrenal (HPA) axis in asthmatic patients is influenced by many factors. Stress, cytokines and exogenous corticosteroids play an important role in regulating the HPA axis and thus affecting the adreno corticotrophic hormone (ACTH) and cortisol levels among these patients. It is well accepted that the HPA axis represents a major immune-regulatory system that pl...
3342
1447
NOVEL THERAPEUTIC OPTIONS FOR FAMILIAL HYPERCHOLESTEROLEMIA
Background: Familial Hypercholesterolemia (FH) is an autosomal dominant disorder caused by mutation in the LDL receptor gene and characterized by raised LDL-C, tendon xanthomata and premature atherosclerosis. Existing therapies for FH such as statins and LDL apheresis do not offer adequate lipid control in most patients, which has led to the search for more definite alternatives. Two new drugs hav...
3369
1563
NEEM LEAF EXTRACT PREVENTS METHOTREXATE INDUCED GENOTOXICITY IN THE SOMATIC CELLS OF DROSOPHILA MELANOGASTER”
Background &Objective: To explore possible protective effect of neem leaf extract against methotrexate induced genotoxicity in the somatic cells (wing primordial) of Drosophila melanogaster. Methods: In the first phase of the experiment, neem leaf extract (NLE) at two doses was tested in the somatic cells (wing primordia) of Drosophila melanogaster (3rd instar trans heterozygous larvae resu...
4115
1629
IN VIVO STABILIZATION STUDIES ON INDIAN COBRA (NAJA NAJA) VENOM FOR ITS TOXICOLOGICAL ACTIVITY (LD50) IN MICE
Biological/Toxicological activity of Cobra venom (CV) is usually estimated in terms of LD50 which varies at each time of test, when stored in liquid condition at non-native environment, as the CV contains most unstable complex proteins in it. Prepared & stored working solution of cobra venom at 5±3ºC in liquid condition for experimentation without any stabilizing agent, it becomes unstable a...
4423
1579
TASKS OF COMPLIMENTARY AND FUNCTIONAL TRIO-MINERALS IN HYPERTENSION
Micronutrient deficiencies such as potassium, magnesium and calcium are very common in the general population and it is more predominantly present in the individuals with hypertension and cardiovascular patients. These deficiencies will have a massive impact on present and future cardiovascular health outcomes such as hypertension, myocardial infarction, stroke, etc. Recent efforts to reduce the p...
3384
1656
MODELING ANTIBACTERIAL ACTIVITY OF 4-THIOZOLIDONE DERIVATIVES
In the present work, efforts have been made to model the antibacterial activity of 4-thiazolidone derivatives against pathogenic bacteria P. aeruginosa by using QSAR (quantitative structure-activity relationship) methodology. Multivariate analysis gave excellent model which was tested using cross validation using leave one out method. The cross- validation method was applied to the data set in ord...
3361
1752
IN SILICO CHARACTERISATION AND COMPUTATIONAL MODELLING OF NEURO-TOXINS OF INDIAN COBRA
Snake venom is cocktail of various enzymes, toxins. Snake venom components have major role as therapeutics application in current drug industry. Snake venom toxins plays vital role as one of the major component in case of bite and most of the toxins are lethal which are of various types such as cardio-toxins, myotoxins and neurotoxins etc. The Indian Cobra neurotoxins sequences were retrieved form...
3855
1704
AN OPTIMIZED SYNTHETIC PROTOCOL FOR BIOLOGICALLY RELEVANT, HIGHLY FUNCTIONALIZED BENZOFURANS
We report here the optimization of an oxidative Michael addition protocol for the synthesis of highly functionalized, biologically relevant benzofurans on gram scale. Rigorous screening of reaction conditions including solvent, atmosphere, base and incubation time, and development of a straight forward precipitation step afforded benzofurans in greater than 95% purity for direct use in biological ...
3529
1971
EXTENDED RELEASE FORMULATION OF THEOPHYLLINE USING MODIFIED FENUGREEK GUM AS A HYDROPHILIC POLYMER
The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet h...
5455
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