ANALYTICAL METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF CANDESARTAN CILEXETIL IN BULK AND PHARMACEUTICAL DOSAGE FORMS BY THIRD ORDER DERIVATIVE SPECTROSCOPIC TECHNIQUE
Candesartan cilexetil, a prodrug is a racemic mixture containing one chiral center at the cyclohexyloxy-carbonyloxy- ethyl ester group. It is soluble in dimethyl formamide, acetone, methanol, 0.1 N sodium hydroxide solution and insoluble in water. Objective of the present study is to develop a simple, sensitive, accurate, precise and rapid derivative spectrophotometric method for the estimation of...
SALUTARY ACTIVITY OF BERBERINE AGAINST DIBUTYLTIN DICHLORIDE INDUCED ACUTE PANCREATITIS IN ALBINO WISTAR RATS
Background: Berberine is a natural alkaloid used as traditional Chinese medicine. Objective: The objective of the present study was to evaluate the effect of berberine on dibutyltin dichloride (DBTC) induced acute pancreatitis in albino Wistar rats. Methods: In this study 24 Wistar rats were randomly selected and divided into four groups. Each group consists of 6 animals. Group-1 (-ve control), Gr...
MICROWAVE INDUCED SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUG SIMVASTATIN USING POLOXAMER 188 BY MICROWAVE IRRADIATION METHOD
To increase the solubility of poorly water-soluble drug simvastatin using hydrophilic carrier poloxamer 188 using solid dispersion techniques by microwave irradiation method. The microwave irradiation technique was used to prepare solid dispersions in minimum time interval in different drug carrier ratios, i.e. 1:2, 1:5, 1:8 and was subjected to microwave for different times, i.e. 3 min, 5 min, an...
SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME NEW4-(SUBSTITUTED\ARYL)-((1, 3–DIPHENYL-1H-PYRAZOLE-4-YL) METHYLENEAMINO)-1, 5-DIMETHYL-2-PHENYLPYRAZOLILDIN-3-ONE DERIVATIVES
Schiff Base derivatives are important class of compounds. They possess different types of Biological activities like antibacterial, antiviral, anti HIV, antifungal etc. Schiff base derivatives are prepared by the condensation of aldehyde and amine and these compounds are characterized by chemical and instrumental methods. Their important biological properties have been investigated....
The main of this study was production of floating tablets to maintain the drug stay in its absorption area. Ciprofloxacin is better absorbed in the stomach because of this reason floating matrix tablet was prepared using novel sintering technique with sodium bicarbonate as gas generating agent and a polymer eudragit robust formulation was decided on the basis of floating time and in-vitro drug rel...
STANDARDIZATION AND QUALITY ASSESSMENT OF TRADITIONAL POLYHERBAL FORMULATION FOR THE TREATMENT OF HEMORRHOIDS (PILES)
Polyherbal formulations are a collection of therapeutic entities that are formulated and prepared on the basis of the healing properties of individual ingredients with respect to the condition of sickness. The main objectives of the present study were to evaluate the pharmacognostic parameters of a traditional polyherbal formulation for the treatment of hemorrhoids (piles). The pharmacognostic par...
Background: Medication errors (MEs) are the potential to cause adverse clinical outcomes. The incidence of MEs is hopefully controlled with patient-centric pharmaceutical services. The present study evaluated the incidence of MEs in various departments in a multispecialty hospital in India. Methods: This prospective observational was analyzed 100 prescriptions included 749 drugs from general medic...
ENHANCEMENT OF BIOAVAILABILITY OF NORFLOXACIN MUCOADHESIVE SUSPENSION BY USING DIFFERENT GRADES OF CARBOPOL
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability an...
FORMULATION AND EVALUATION OF NOVEL SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM OF SUMATRIPTAN SUCCINATE
In migraine disease which is an autoimmune disorder, 5-HT1 receptor agonist like Sumatriptan succinate (STS) is widely used. Its bioavailability is 15-17% due to extensive presystemic metabolism. The objective of this work was to prepare Sumatriptan succinate (STS) in a self nanoemulsifying drug delivery system (SNEDDS) and then convert it into solid-SNEDDS (S-SNEDDS) via extrusion/spheronization ...
SYNTHESIS AND CHARACTERIZATION OF NOVEL CHOLESTERYL LACTATE BASED FATTY ACID ANALOGS AND THEIR IN VITRO ANTIMICROBIAL ACTIVITY
A series of novel cholesteryl lactate-fatty acid conjugates (4a-i) were prepared by esterification of cholesterol with lactic acid, followed by coupling hydroxyl group of cholesteryl lactate with –COOH group of fatty acids including, saturated fatty acids of varying carbon chain of C10-C18, unsaturated fatty acids like 10-undecenoic, oleic ((9Z)-octadec-9-enoic), ricinoleic ((9Z,12R)-12-hydroxyo...