DESIGN AND EVALUATION OF AMOXICILIN TRIHYDRATE FLOATING GRANULES PREPARED BY MELT GRANULATION TECHNIQUE
The purpose of this study was to design and evaluate Amoxicillin trihydrate floating granules by melt granulation technique using Gelucire 43/01 and Campritol 888 ATO as lipid carriers. Polymers HPMC K4M and Ethyl Cellulose as release rate modifiers. The granules were evaluated by FTIR studies, differential scanning calorimetry, Scanning Electron microscopy, drug content, in vitro floating ability...
In this work, an attempt was made to synthesize new chalcones by Claisen - Schmidt condensation of substituted benzaldehydes with 4-aminoacetanilide in the presence of base catalyst. The synthesized chalcone derivatives was characterized by FT-IR, 1H-NMR, and 13C-NMR and also tested for their antimicrobial activity and compared with the standard drugs....
COMPARATIVE STUDY OF ROPIVACAINE WITH CLONIDINE AND ROPIVACAINE ALONE IN SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK
Background: Brachial plexus block provides minimal systemic impairment and excellent localized postoperative analgesia for upper extremity surgery. LA’s such as lignocaine, bupivacaine and ropivacaine are widely used along with adjuvant to improve the quality, onset and duration of block and to decrease postoperative analgesic requirement and systemic side effects. Adjuvant like α-2 agonist (Cl...
A diet rich in marine fishes and general seafood has long been recommended by several medical authorities as a long-term nutritional intervention to preserve overall health and wellbeing. An association between consumption of fish and seafood and beneficial effects on a variety of health outcomes has been reported in epidemiologic studies and clinical trials. These effects are mainly attributed to...
This study was carried out to investigate the acute oral toxicity LD50 of an anti-neoplastic and a chemotherapeutic agent hydroxyurea in male albino mice by using up α Down method. The result revealed that LD50 of hydroxyurea was (7868.5 mg/kg. b.w). Orally after 24 h of exposure. That’s mean it is slightly toxic agent. To study the effect of lethal doses of hydroxyurea on the some of blood par...
The work was under taken as an attempt to prepare quick release films of ebastine with the purpose of developing a dosage form for very quickly on set of action, which will be beneficial in managing severe condition of allergies, aiding in enhancement of bioavailability. It is necessary to prepare ebastine as fast dissolving oral films to bypass the first pass metabolism. Ebastine was prepared as ...
Objective: To assess the drug utilization evaluation of antihypertensive agents in diabetic and non-diabetic patients with chronic kidney disease. Method: Retrospective observational study was conducted in inpatient Nephrology department of B.B.R. Hospital from Sep 2016 to Feb 2017 and 155 case records of patients diagnosed with CKD and HTN, above 18 yrs of age, belonging to both genders were coll...
PREVALENCE of AmpC β-LACTAMASE IN PLASMID RESISTANT GENE FROM UTI CLINICAL ISOLATES BY MOLECULAR TECHNIQUES
Objective: To detect the prevalence of Plasmid resistant AmpC β-lactamases gene in clinical isolates of gram negative organisms from UTI patients which produce resistance against multiple antibiotics. The gene coding for AmpC β-lactamases is also present in E. coli & Klebsiella species was not expressed because due to lack of promoter region, but the transfer of chromosomal genes to plasmids...
The whole plant of Cocculus pendulus (J.R. & G. Forst.) Diels is reported to have quality medicinal values in traditional system of medicines. The various physico-chemical parameters included determination of extractive value, loss on drying, ash values, fluorescence analysis, HPTLC analysis and preliminary phytochemical analysis were performed. The preliminary identification of Cocculus pendu...
SCREENING OF SULPHUR OXIDIZING BACTERIA FROM SULPHUR SPRINGS OF SAHASTRADHARA REGION OF DEHRADUN, UTTARAKHAND, INDIA
Sulphur water is commonly used as the remedial source for treating skin infections and eradicating pathogenic microbes causing infection. The sulphur water is the source of sulphur oxidizing bacteria which is the source of different secondary metabolites which has potential killing activity against different skin borne infections. In the present investigation, the study was performed to isolate an...