Volume 1 (2010) - Issue 5, May
Hypertension is a common problem facing many peoples today. Although billions of dollars are spent annually for the treatment and detection of cardiovascular disease, current conventional treatments have done little to reduce the number of patients with hypertension. Alternative medicine offers an effective way to decrease the rising number of people with high blood pressure. Research has found a ...
In recent years, development in science and technology has brought about significant changes to world in which we live. One such change has been the introduction of cosmetic surgery into mainstream life, having growth from being the presence of rich and famous to being an increasingly accepted option for ordinary people. Cosmetic surgery is a special branch of surgery that deals with the medical c...
The chemistry of pyrimidine is a blossoming field. Numerous method for the synthesis of pyrimidine and also their diverse reactions offer enormous scope in the filed of medicinal chemistry. The utility of pyrimidines as synthon for various biologically active compounds has given impetus to these studies. The review article aims to review the work reported and the chemistry and biological activitie...
Despite of tremendous advancement in drug delivery the oral route of drug administration is the most important method of administration of drug for systemic effect. The parenteral route is not routinely used for self administration of medication. It has been known for centuries that buccal and sublingual administration of drug solute is rapidly absorbed into the reticulated vein, which lies undern...
The plant Tephrosia purpurea L. is commonly known as Unhali. T. purpurea (Leguminosae) is a copiously branched perennial herb. Present work was undertaken to study antioxidant potential of the plant. Dried ethanol and aqueous extracts plant were screened for in-vitro antioxidant activity by DPPH assay and nitric oxide screening methods. Results showed that IC50 value of aqueous extract in DPPH ass...
The present endeavour was directed towards fabrication of the novel colon drug delivery system of ketorolac tromethamine capsule. Hard gelatin Capsules were fabricated using combination of both microflora activated natural polysaccharide (guar gum) and pH-dependent polymer (cellulose acetate phthalate). In vitro drug release studies revealed that Ketorolac tromethamine granules bearing hard gelati...
A microwave assisted extraction technique was developed to optimize the extraction of mucilage from the fruits of Trichosenthes dioica plant. Materials and Methods: the plant has been extracted by conventional and microwave assisted methods for the isolation of mucilage. Results and Discussion: Microwave extraction at 320 W intensity and 20 min heating duration, 84.92% increase in the yield of muc...
EVALUATION OF ANTIOXIDANT, WOUND HEALING AND ANTI- INFLMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF LEAVES OF FICUS RELIGIOSA
The present study deals with evaluation of antioxidant, wound healing and anti-inflammatory activity of ethanolic extract of leaves of Ficus religiosa. The ethanolic extract prepared by maceration technique was subjected to screen for antioxidant activity using DPPH radical scavenging method and wound healing activity using incision, excision, histopathological and dead space wound model and the s...
Objective of the study was to assess the anticonvulsant activity of extracts of Hibiscus rosa sinesis in albino rats. Methods: The anticonvulsant activity of extracts of flowers of Hibiscus rosa sinesis in rats were assessed using maximum electroshock seizure (MES) test and isoniazid (INH) using albino rats. The time taken before the onset of clonic convulsions, the duration of colonic convulsions...
ONCE DAILY GASTRO RETENTIVE MUCOADHESIVE CEPHALEXIN MONOHYDRATE TABLET: FORMULATION AND IN-VITRO EVALUATION
Oral drug administration has been the predominant route for drug delivery due to the ease of administration, patient convenience and flexibility in formulations. Mucoadhesive tablets of Cephalexin monohydrate were prepared with an objective to increase the bioavailability by minimizing the first pass metabolism and also to reduce the frequency of administration. Carbopol 934p as a primary polymer ...
POSSIBLE MECHANISM OF HYPERGLYCEMIA INDUCED DECREASE IN ANTINOCICEPTIVE EFFECT OF ANALGESICS IN RATS
Diabetes induced neuropathic pain is recognized as one of the most difficult pain to treat and conventional analgesic are well known to be partially effective or ineffective. Non-steroidal anti-inflammatory drugs and opioids are effective antinociceptive drugs, however, their antinociceptive activity decreased in diabetic neuropathy. The study was designed to investigate the mechanism of diabetes ...
Inflammation is a biological reaction attributed with several acute and chronic pathological conditions. The study revealed the pharmacological effect of Tecomella undulate: bark against carrageenan induced paw edema and cotton pellet induced granuloma in rat. Wistar albino rats of either sex (180-240 g) were employed into the study. Acute inflammation was induced by injecting carrageenan (1%) in ...
The different extracts of the roots of Bruguiera gymnorhiza (Family- Rhizophoraceae) were tested for anti-diabetic activity, by glucose tolerance test in normal rats and alloxan induced diabetic rats. Aqueous ethanol and butanol extracts had shown significant protection and lowered the blood glucose levels to normal in glucose tolerance test. In alloxan induced diabetic rats the maximum reduction ...
A simple, sensitive and selective high performance liquid chromatography (HPLC) method with ultraviolet detection (220 nm) was developed and validated for the quantification of Ibuprofen and in human plasma. Following rapid sample preparation, the analytes and internal standard (Diclofenac sodium) were separated using an isocratic mobile phase on a reverse phase C8 column. The lower limit of quant...
Tuberculosis is declared to be an infectious disease of global emergency by WHO. Approximately one-third of the world’s population is infected with the tuberculosis. The lengthy and laborious current treatment of 6-9 months is associated with problems like patient noncompliance, multiple drug resistance and persistence of mycobacterium and significant toxicity of drugs. The increasing emergence ...