Volume 14 (2023) - Issue 1, January
Review Articles
A REVIEW ON CARBON DOTS PRODUCED FROM BIOMASS WASTE-ITS DEVELOPMENT AND BIO-APPLICATIONS
Carbon nanomaterials belong to the carbonaceous family of less than 10 nm in size called Carbon dots (C-dots); the latest class of engineered nanoparticles has recently gained popularity for their unique characteristic features, such due to their low toxicity and miniature size, it can penetrate cells easily, thus becoming highly biocompatible. The advancement of science and its collaboration with...
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APPLICATIONS OF ELECTROSPUN NANOFIBERS IN THE TREATMENT OF PERIODONTAL DISEASES
A periodontal disease is a group of pathological diseases, i.e., a widespread infectious disease that mainly causes tooth loss in 15% of adults worldwide. For the treatment of these periodontal diseases, localization of the drug is necessary i.e.; the drug has to be delivered to the periodontal pocket, which is the main area for the development of bacteria. So, researchers have made many attempts ...
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POTENTIAL OF NANOPARTICLES IN THE EFFECTIVE MANAGEMENT OF BREAST CANCER
Breast cancer (BC) is one of the most prevalent cancers in women; there were 2.3 million women diagnosed with breast cancer globally. Unfortunately, most anticancer drugs have reported high Potential toxicity, mutagenic and carcinogenic side effects. Existing treatments can neither stop its propagation and/or recurrence nor are specific for cancer cells. Hence the side effects on healthy tissues a...
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LIPOSOME IN COSMETIC DRUG DELIVERY SYSTEM OF PHOSPHOLIPID AND PHENOLIC COMPONENT
Liposomes are considered to be safe for usage; they have been used hugely in cosmetics. Biologically obtained compounds of phospholipids have a high affinity to the skin's surface. Liposomes are highly permeable and have more storage capacity on the stratum corneum and also it is considered a chemically active agent to the skin. Most future studies on liposomes involve drug delivery in cosmetics. ...
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COMPARITIVE REVIEW ON ANTI-ULCER ACTIVITY OF SOME MEDICINAL PLANT EXTRACTS
Peptic ulcer is an excavation of mucosa and may extend to the submucosal layer. The bacterium Helicobacter pylori is regarded as the most common cause of infection. Long-term use of NSAIDs (non-steroidal anti-inflammatory disease drugs) like Aspirin, Diclofenac, and Naproxen and stress were also regarded as causes of ulceration. Ancient technology of synthesizing and utilizing plant-based medicine...
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SCOPE OF NANOTECHNOLOGY IN NUTRACEUTICALS, COSMECEUTICALS AND DENTISTRY – REVIEW
Nanotechnology is predicted to change health care essentially. The word nano originates from the Greek word "dwarf". The idea of nanotechnology was first explained in 1959 by Richard Feynman. Nanotechnology has applications in many fields, including Medicine, Diagnostics, Drug delivery, Tissue engineering, Pharmaceuticals, Cosmeceuticals, Nutraceuticals, Dental materials, the Food industry etc. N...
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EMERGING ROLE OF NUTRACEUTICALS IN THE MANAGEMENT OF HYPERTENSION: A SYSTEMATIC REVIEW
Nutraceutical is a word obtained from Nutrition and Pharmaceuticals. Nutrients are a feed constituent that helps to support the life of human beings or animals. Pharmaceutical components are non-toxic food constituents, including prevention and treatment of disease. They commonly inhabit the disorders associated with oxidative stress, for instance, cardiovascular disease, Diabetes, and Hypertensio...
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FICUS BENJAMINA: PHYTOCHEMICAL AND PHARMACOGNOSTIC PERSPECTIVE
In the present study, phytochemical and pharmacological properties of species of F. benjamina have been discussed. The phytochemical and pharmacological properties correlate with various active constituents of the plant. Ficus belongs to the Moraceae family, found in Asia and Australia, and widely distributed in tropical and subtropical areas, including more than 800 species. The genus Ficus const...
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OVERVIEW OF SOLID LIPID NANOPARTICLES FOR IMPROVED ANTI-CANCER DRUG DELIVERY
Nanoparticles with lipids as a constituent are called "solid lipid nanoparticles" (SLNs). Based on the most recent trends, SLNS is a promising approach for overcoming multiple barriers in drug delivery. Through SLNs, maximized drug payload to the site of action for different pharmaceutical drugs can be achieved. They range in size from 10nm to 1000nm and possess a solid lipid core matrix that aid...
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3D PRINTING – A NEW TECHNOLOGY FOR THE PHARMACEUTICAL INDUSTRY
Three-dimensional printing (3DP) is an imminent technology used to describe 3D products generated using a digital design platform manufactured layer by layer. This technology appears to be a transformative tool. It has just emerged as a key technological breakthrough, allowing the pharmaceutical sector to develop and generate new pharmaceutical items and equipment. It's a brand-new way to personal...
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SESAME SEEDS: A PROMISING ANTI-DIABETIC AGENT
The day-by-day escalation of different diseases worldwide increases the demand for newer drugs with better therapeutic effects. Nature attracts researchers due to its rich herbal sources with potent effects against various diseases. Sesame seed acts as a reservoir for various bioactive components, exhibiting tremendous beneficial effects on human health. Sesame seed is not just only seeds that are...
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REVIEW ARTICLE: ANALGESIC ACTIVITY OF A POTENTIAL SOURCE OF MODERN MEDICINE
Recently, scientific investigations of medicinal plants using indigenous medical systems have attracted a lot of attention in international investigation. Nature has imparted our planet with an enormous wealth of medicinal plants known for bestowing and are highly esteemed worldwide as a rich source of therapeutic agents for the prevention and cure of diseases and ailments. Since their chemical ch...
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MICELLAR LIQUID CHROMATOGRAPHY, A GREEN TECHNIQUE FOR ANALYSIS OF DRUG FORMULATIONS; A REVIEW
The most commonly used analytical method in drug research is reversed-phase high-performance liquid chromatography (RP-HPLC). RP-HPLC methods also use huge quantities of solvents and generate by-products that must be disposed of, posing environmental and operator health worries. Micellar Liquid Chromatography (MLC) is a green chromatographic process for pharmaceutical analysis in which surfactants...
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PULSATILE DRUG DELIVERY SYSTEM- A SYSTEMATIC REVIEW
Conventionally, drugs are released abruptly or comprehensively. But, in current years, pulsatile drug release systems (PDRS) are ahead raising attention. From PDDS, the drug is liberate quickly after a well defined insulate-time, could be helpful for many medicines or treatments. It can be labeled in single and a couple of-pulse structures. Other structures consist of a drug-enclosed core, enclose...
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IMPLEMENTATION OF ROBOTICS AND ARTIFICIAL INTELLIGENCE IN THE PHARMACEUTICAL SECTOR
The rapid development of artificial intelligence (AI) has far-reaching consequences for the global economy. Computers are helping with human input, decision-making, and data provision in medicine more than ever before. AI, algorithms, robotics, and big data are all used in today's healthcare sector and the medical profession to derive inferences for monitoring large-scale medical trends and detect...
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A REVIEW ON DRUG ADDICTION AND HABITUATION AND TREATMENT FOR DRUG ADDICTON
Drug addiction has become a worldwide problem and the leading cause of death. In recent years, India is seeing a rising trend in drug addiction. The most common drug use in India is alcohol, followed by cannabis and opiates. Drug use, whether licit or illicit, causes serious health problems in individuals. The national survey on drug use in India indicated that the prevalence of drug abuse among m...
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REPLACEMENT OF ORGANIC SOLVENTS WITH ENVIRONMENTAL ECO-FRIENDLY SOLVENTS FOR RP-HPLC ANALYSIS
Background: Solvents are major part in chemical industry. Solvents have major impact on cost as well as safety and health issues. Many more organic solvents are considered toxic. Thus the concept of green chemistry is introduced which eliminate or reduce the use of hazardous solvents/chemicals from analytical process for the eco-friendly environment and health without any compromise in Analytical ...
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A BRIEF SCIENTIFIC EVIDENCE OF ETHNOBOTANICAL AND PHARMACOLOGICAL STUDIES OF SOLANUM INDICUM LAM.
Poisonberry is the colloquial name for Solanum indicum Linn. It grows to over one meter in height and is thorny and densely branched. It is usually found in India's warmer regions, up to an altitude of 1500 meters. This important medicinal plant treats respiratory infections, skin infections, ulcers, dyspepsia, cough, and stomach discomfort in Ayurveda and Siddha, the Folk and Traditional Indian s...
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BIOLOGICAL SIGNIFICANCE OF PHYTO-CONSTITUENTS OF MEDICINAL PLANTS IN MAINTAINING VISION & HEALTHY EYE SIGHT
The eye is one of the most sensitive organs of human body and is continuously exposed to different environmental agents so it is very important to take care of eyes. Poor vision makes it harder to read, drive, and cook. Many eye problems and diseases can be treated if caught early. Ophthalmologists will examine eyes for signs of vision problems or eye diseases. It's the best way to find out if gla...
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REVIEW ON VOSORITIDE: ACHLONDROPLASIA
BioMarin Pharmaceutical is developing Vosoritide, a modified recombinant human C-type natriuretic peptide (CNP) analogue for the treatment of achondroplasia. A gain-of-function mutation in the fibroblast growth factor receptor 3 gene (FGFR3), a negative regulator of bone growth, causes achondroplasia. Vosoritide works to restore chondrogenesis by attaching to the natriuretic peptide receptor B (NP...
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COMMON INDIAN MEDICINAL PLANTS AS EMERGING WOUND HEALING AGENTS: DEEP INSIGHTS INTO APPLICATIONS AND MECHANISMS
Any bodily harm, such as damage to the skin's epidermis and disruption of its normal architecture and function, is referred to as a wound. The significance of wound healing has been known since ancient times. Several attempts have been made to design innovative wound dressings composed of the finest materials for speedy and successful wound healing. Medicinal herbs greatly aid the wound healing pr...
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SYSTEMATICALLY REVIEWING THE HIGH-PERFORMANCE LIQUID CHROMATO-GRAPHY (HPLC) ANALYTICAL METHODS FOR DETERMINING METFORMIN IN DIFFERENT PHARMACEUTICAL FORMULATIONS AND HUMAN SAMPLES
Metformin (MET) is a biguanide class of oral hypo-glycaemic agent which is used in the treatment of diabetes mellitus type II. Currently, MET is the first drug of choice and is primarily prescribed by medical practitioners to at least 120 million people worldwide. The quality-oriented routine analysis of various commercially available products of MET is a major challenge. Several methods have been...
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Research Articles
MITIGATION OF PAIN AND INFLAMMATION-INDUCED IN MICE AND ANTIMICROBIAL ACTIVITY OF CRUDE HYDROALCOHOLIC EXTRACT DE BEGONIA CUCULLATA WILLD. (BEGONIACEAE)
Begonia cucullata Willd. (Begoniaceae) is a native medicinal species from Paraguay popularly used to combat stomatitis, pharyngitis, respiratory ailments in children, and inflammatory conditions among others. The limited literature did not report these plants as having analgesic, anti-inflammatory, or antimicrobial properties. This work aims to determine the acute toxicity, general behavior, analg...
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COMPARISON OF EIGHT METHODS FOR ESTIMATION OF CREATININE CLEARANCE IN MALAYSIA PATIENTS WITH UNSTABLE KIDNEY FUNCTION – A MULTI-CENTER, PROSPECTIVE, OBSERVATIONAL STUDY
Estimation of creatinine clearance (Clcr) has long been a problem in critically ill patients with unstable kidney function. The commonly used methods like the Cockcroft-Gault method require a stable kidney function. A reliable and more accurate tool is needed to estimate Clcrto to guide drug dosage adjustment. The study aimed to compare the eight methods to estimate Clcr with measured Clcr. In add...
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ISOTINE, AN HERBAL EYEDROPS, IMPROVES CATARACT-INDUCED BLINDNESS: A RETROSPECTIVE OBSERVATIONAL STUDY
Gradual vision loss is linked to degenerative changes and cataract. The Isotine-herbal eyedrop has been clinically used for 36 years with a claim to reverse the cataract-induced visual impairment. This retrospective observational study on 308 cataract patients, registered between 2017 to 2019 at Basu Eye hospital, Bareli, UP, India, having 3 months of treatment, shows the significant therapeutic r...
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DEVELOPMENT AND CHARACTERIZATION OF SOLID LIPID NANOPARTICLES CONTAINING ANTI-FUNGAL AGENT FOR TOPICAL DELIVERY
Fungal infection is becoming more common all over the world. Oral therapy for fungal infections is linked with toxic effects, a long treatment period, and patient intolerance. In contrast, the link between topical therapy and superficial fungal infections is low drug solubility, skin irritability, and low permeability via the skin. Top topical therapy would aim to improve the penetration of poorly...
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MORPHOMETRY OF HUMAN SCAPULA GLENOID FOSSA AND ITS SURGICAL ANATOMY: AN OBSERVATIONAL STUDY IN EASTERN ODISHA
Introduction: Scapulae bear a shallow articular concave fossa commonly known as glenoid cavity that accommodates the head of the humerus to form a shoulder joint. The size and shape of glenoid fossa is highly variable; hence, knowledge about morphological measurements is invariably essential for surgery and artificial prosthesis pertaining to shoulder joint pathology. Aim: Glenoid fossa morphome...
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LIVER PROTECTIVE ACTIVITY OF COCCINIA GRANDIS FRUITS EXTRACT AGAINST ANTI-TUBERCULAR DRUGS INDUCED LIVER TOXICITY IN RATS
To investigate the hepatoprotective activity of Coccinia grandis fruit extract against anti-tubercular drugs induced hepatotoxicity in rats. 50% ethanolic extract of Coccinia grandis (CGE 200 and 400 mg/kg body weight) was administered daily for 9 days in experimental animals. To develop hepatotoxicity, animals were administered orally with Isoniazid (50 mg/kg, p.o.) and Rifampicin (100 mg/kg, p.o...
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COMPARATIVE EVALUATION OF CONTACT ANGLES OF ROOT CANAL SEALERS TO GUTTA PERCHA- AN IN-VITRO STUDY
Adhesion of endodontic sealers to Dentine and Gutta percha (GP) provides an understanding of the interactions between the root canal wall and the core material. The interaction of Bioceramic sealers has been studied previously but the wetability to Gutta percha has rarely been evaluated. Hence, the present in-vitro study was designed to evaluate and compare the wetability of five different root ca...
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QUANTITATIVE EVALUATION OF IMPURITIES G AND S IN VALACICLOVIR HYDROCHLORIDE HYDRATE ACTIVE PHARMACEUTICAL INGREDIENT USING LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY ANALYTICAL METHOD
Current work makes known that Liquid Chromatography-Mass Spectrometry (LC-MS) method development and validation for the impurity G (N, N -dimethylpyridin-4-amine) and impurity S (2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl) methoxy] ethyl N-[1,1-dimetylethoxy) carbonyl]-L-valinate) in Valaciclovir Hydrochloride Hydrate active pharmaceutical ingredient (API). The developed LC-MS analytical method i...
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AMELIORATION OF INFLAMMATION AND CARDIOPROTECTIVE EFFECT OF TERMINALIA ARJUNA BARK EXTRACT IN HIGH-FAT DIET RAT MODEL
The objective of this study is to investigate the protective effect of aqueous bark extract of Terminalia arjuna (TA) on high-fat diet-induced cardiovascular changes in Wistar rats using histological, immunohistochemical, and gene expression analysis. Group 1- without treatment served as control, group 2- High fat diet (HFD) received corn oil orally at a dose of 10 mL/kg, group 3 - HFD+atorvastati...
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SYNTHESIS OF (2, 4-DIMETHOXY – 3 – ((3 – PHENYL – 4, 5 – DIHYDROISOXAZOL – 5 – YL) METHOXY) PHENYL) (PHENYL) METHANONE AND THEIR ANTIBACTERIAL ACTIVITY
In this study, a series of novel Synthesis of (2,4-dimethoxy-3-((3- phenyl-4, 5- dihydroisoxazol-5-yl) methoxy) phenyl) (phenyl) methanone (8a-p), were synthesized from condensation of an equimolar quantity of aryl (3- hydroxy-2, 4-dimethoxyphenyl) methanones (4a-d) and 5-(bromomethyl)-3- phenyl-4,5-dihydroisoxazole (7a-d) in DMF solvent by employing anhydrous potassium carbonate (K2CO3) as a base...
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CHITOSAN CO-CRYSTAL FOR ENHANCING THE SOLUBITY AND DISSOLUTION RATE OF DICLOFENAC SODIUM
The present study is designed to enhance the aqueous solubility of diclofenac sodium. For the said purpose co-crystal employing chitosan with diclofenac sodium is prepared by solvent exchange. The prepared co-crystal was characterized by FTIR, DSC, XRD and TGA studies. Further, solubility, anti-inflammatory activity and in-vitro release study was determined for different batches of the formulation...
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BIOPHYSICAL CHARACTERIZATION AND FUNCTIONAL ANNOTATION OF ENOLASE PROTEIN IN ANUSTRCA ANNLIPES
Anustrca annlipes (fiddler crab), often called crab, are decaped crustaceans of the uca family. They belong to the ocypodidae family, which contains over a hundred species of semi-terrestrial sea crabs. 11 of the 13 genera in the ocypodidae crab family are made up of more than 100 fiddler crab species. The species can be found on sea and brackish intertidal mud flats, lagoons and swamps, mangroves...
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ANTIOXIDANT CAPACITY, CHROMATOGRAPHIC ANALYSIS OF PHENOLIC COMPOUNDS AND ANTI-MICROBIAL EFFECTS OF CARDARIA DRABA GROWING IN IRAN
In the present study, the antioxidant and anti-microbial potential of aerial and underground parts of the Cardaria draba (L.) Desv. Different tests evaluated methanolic extracts. The phenol and flavonoid contents of the extracts were investigated by Folin Ciocalteu and AlCl3 assays. Phenolic compounds analyzed By HPLC method. DPPH Radical-Scavenging, reducing power, nitric oxide-scavenging, and Fe...
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TO STUDY THE ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF OIL FROM LEAVES OF CAMELLIA SINENSIS L. IN EXPERIMENTAL ANIMAL MODELS
The present study has been conducted to search out the anti-oxidative and anti-inflammatory potential of leaves of Camellia sinensis L. oil (Tea oil, TO). Forty-eight rats were included for 14 days experiment namely: Group I was normal to control, Group II was vehicle control, and Group III to VIII rats were subjected to paracetamol at the dose of 15 mg/ kg body weight/day to induce oxidative st...
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QBD APPROACH TO DEVELOP RP-HPLC METHOD FOR CAPECITABINE IN BULK AND DOSAGE FORM
A simple, specific, accurate, reliable, and precise reverse-phase high-performance liquid chromatographic method was developed by quality by design approach and validated for the estimation of Capecitabine in bulk and tablet dosage forms. A surface methodology was used to optimize the data with a three-level Box Behnken Design (BBD) was used. Mobile phase composition, flow rate, and column oven te...
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FORMULATION AND EVALUATION OF GLIBENCLAMIDE ORAL DISPERSIBLE TABLET BY SOLID DISPERSION TECHNIQUE
Glibenclamide belongs to a group of medicines called sulfonylureas. Glibenclamide is used to manage diabetes. Glibenclamide, also known as glyburide, is an antidiabetic medication used to treat type 2 diabetes. The purpose of the present study was to formulate an Oral dispersible tablet of Glibenclamide using the Solid dispersion technique through using polyethylene glycol ratio as a water-solub...
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HISTOLOGICAL AND PHYTOCHEMICAL ANALYSIS OF FOUR ETHNOMEDICINAL PLANTS USED TO CURE SKIN DISEASES
Natural plant-derived compounds have been an essential resource in the evolution of drug discovery since the dawn of time. Using plants as a source of medicine is a century-long-standing tradition not merely in India but also in the entire world. North-East India is bestowed with incredible biological richness. The current research is focused on the histological and phytochemical analysis of four ...
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ESTIMATION OF TOTAL FLAVONOIDS AND TOTAL PHENOLIC CONTENTS AND ANTIOXIDANT ACTIVITIES OF PTEROCARPUS SANTALINUS LINN
Plants and plant-based medicaments are the basis of many of the modern pharmaceuticals we use today for our various diseases. Pterocarpus santalinus Linn (Fabaceae) is a small to the medium-sized deciduous tree is widely distributed in the tropical regions of the world. The plant is mainly used to cure skin ailments, cough, hyper nervous activity and is also used as an anti-inflammatory, anti-canc...
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ESTIMATION OF IMMUNOMODULATORY AND ANTI-DIABETIC MICRONUTRIENTS FROM SIX DIFFERENT LEAFY VEGETABLES OF BENGAL
Micronutrients are essential nutritional elements that assist the body in synthesizing enzymes, coenzymes, prosthetic groups, hormones, and other compounds important for living beings' progress and expansion. Trace elements are one of the important part of micronutrients. Trace elements have an important impact on human health and have a wide range of metabolic properties and performance, although...
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A SIMPLE, EFFICIENT AND GREEN PROCEDURE FOR THE SYNTHESIS OF 2, 4, 5-TRISUBSTITUTED IMIDAZOLE DERIVATIVES USING NOVEL PEG-SOCl AS A CATALYST
A facile, highly efficient, simple, and convenient method for synthesizing 2, 4, 5-trisubstituted imidazole derivatives from the condensation of various substituted benzaldehyde, benzil, and ammonium acetate by using a catalytic amount of PEG-SOCl in the presence of water at room temperature or under microwave irradiation. PEG-SOCl is an effective heterogeneous catalyst and easy to separate. We ha...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL5, 6-DIHYDRO-3-(SUBSTITUTED PHENYL) [1, 2, 4] TRIAZOLE (3, 4-B) [1, 3, 4] THIADIAZINE-7-ONE DERIVATIVES FOR ANTIMICROBIAL AND FREE RADICAL SCAVENGING ACTIVITY
The present research aims to synthesize novel 5, 6-dihydro-3-(substituted phenyl) [1, 2, 4] triazolo (3, 4-b) [1, 3, 4] thiadiazine-7-one derivatives and their physiochemical evaluation for antibacterial and antioxidant activities. Novel synthetic schemes were designed to synthesize compounds (1-6), which were then characterized using physicochemical and spectroscopic methods (IR, 1HNMR). In-vitro...
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DESIGN, DEVELOPMENT AND STATISTICAL OPTIMIZATION OF ACYCLOVIR-LOADED PROTEIN NANOPARTICLES
To solve the problem of low drug availability in the body, acyclovir was fabricated into biodegradable gelatin nanoparticles by step-wise two-times desolvation method where gelatin was used as biodegradable polymer and glutaraldehyde was utilized as a cross-linking agent. Optimization was conceded by design expert computational application whereby the outcome of gelatin polymer concentration (X1...
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SOLUBILITY ENHANCEMENT AND QUALITY BY DESIGN (QBD) ASSISTED FABRICATION OF FAST DISSOLVING BUCCAL FILM FOR RISPERIDONE
Rapidly Dissolving Drug Delivery Systems have become interested in the pharmaceutical industry as frameworks that provide quick onset of action with enhanced dissolution characteristics. Risperidone, a poorly water-soluble drug, is a second-generation antipsychotic of the benzisoxazole derivatives used in treating schizophrenia and other mood disorders. The present research work aimed to fabricate...
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EVALUATION OF ANTIOXIDANT ACTIVITY AND QUANTIFICATION OF α–ASARONE IN RHIZOMES OF ACORUS CALAMUS L. USING HPTLC FINGERPRINTING
This study aimed to analyze antioxidant activity and quantify alpha-asarone by using High-performance thin-layer chromatography (HPTLC). Alpha-asarone is a secondary metabolite in hydroalcoholic (1:1) rhizome extracts of Acorus calamus L. (AC), a medicinal plant being used around the globe traditionally. Sweet flag, AC is a member of the Acoraceae family, and is commonly used unaided as well as in...
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THE METHANOLIC EXTRACT OF ALBIZIA ODORATISSIMA BARK ATTENUATED THE DEVELOPMENT OF DIABETIC NEPHROPATHY IN RATS
Purpose: The present study has been designed to investigate the protective effect of methanolic extract of Albizia odoratissima (AO) bark in prevention of streptozotocin (STZ) induced-diabetic nephropathy (DN) in Wistar rats. Methods: Healthy Wistar rats of either sex weighing 180-200g were employed in the present study. Experimental diabetes was induced in rats by injecting STZ at a dose of 45 mg...
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SQUALENE: A POTENTIAL ANTI-ALZHEIMER’S COMPOUND IN ALBINO RAT
Alzheimer’s disease, the most scattered neurodegenerative disease causes progressive destruction in serviceable performances and continuous reduction in cognitive activities and memory in aged people. It is estimated that people suffering from AD is about 10% between 65-70 years and 50% in people above 85years of age and this number will double every two decades. Even though extensive research h...
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FORMULATION AND EVALUATION OF LIQUID-FILLED HARD GELATIN CAPSULE OF DICLOFENAC POTASSIUM
Background Diclofenac Potassium is the potassium salt form of diclofenac, a benzene acetic acid derivate, and nonsteroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic and anti-inflammatory activity. Aim: Therefore, the purpose of the present study was to formulate and evaluate liquid-filled hard gelatin capsules of diclofenac potassium. Methods: The liquid-filled soft gelatin c...
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FORMULATION, OPTIMIZATION AND EVALUATION OF HEXADECANOIC ACID PHYTOSOMAL GEL FOR ANTI-FUNGAL ACTIVITY
Phytosomes is vesicular drug delivery system in which phytoconstituents of herb extract surround and are bound by lipid. Hexadecanoic acid is the phytoconstituents of Nigella sativa oil. Hexadecanoic acid is hydrophobic and possesses less solubility and permeability. The study aims to formulate, optimize, and evaluation of hexadecanoic acid phytosomal gel for anti-fungal activity hexadecanoic acid...
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