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ISSN (Online): 0975-8232,
ISSN (Print): 2320-5148

International Journal Of
Pharmaceutical Sciences And Research

An International Journal published monthly
An Official Publication of Society of Pharmaceutical Sciences and Research

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Volume 14 (2023) - Issue 12, December

Review Articles

 
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1.

IN-VIVO MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE

Non-alcoholic fatty liver disease (NAFLD), a common chronic liver condition, is high in developed nations. One of the factors leading to chronic liver disease and cryptogenic cirrhosis has been identified as NAFLD. Multiple risk factors, including obesity, insulin resistance, diabetes mellitus, hyperlipidemia, and hypertension-related cardiovascular disease, contribute to the development of NAFLD....

Deepti D. Bandawane *, Nikita G. Pawar, Gayatri J. Gadekar, Pranali A. Bhandare and Mohsin A. Mansoori

Department of Pharmacology, P.E.S. Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5555-64

5555-5564

476

533

2.

AN EXTENSIVE REVIEW ON EFFECTS OF PSYCHOBIOTIC BASED TREATMENTS IN AUTISTIC SPECTRUM OF DISORDER AND APPLICABILITY OF ZEBRAFISH AS A ROBUST MODEL FOR STUDYING ASD

Autism spectrum disorders (ASDs) refer to the group of neuropsychiatric disorders that alter neurodevelopment and mental function and are characterised by an extensive range of symptoms, including hyper-or hyposensitivity, repetitive behaviours, and impairments in social and academic functioning. Untangling the causation of ASD has been complicated, in part because distinct genetic abnormalities ...

Anusha Samanta and Tamalika Chakraborty *

Department of Life Science, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5565-77

5565-5577

439

276

3.

CURRENT LANDSCAPE FROM CLINICAL TRIALS AND FUTURE OF COMBINED CHECKPOINTS BLOCKADE IMMUNOTHERAPY IN CANCERS

Immunotherapy is among cancer immunology's fastest and most furious treatment strategies. The therapeutic perspective of checkpoint inhibitors is represented through the Food and Drug Administration (FDA) approvals for their implementation in various malignancies. Efforts to improve results with immunotherapeutic agents have led to the design of advanced treatment strategies. Current pre-clinical ...

Ashish Shivram Ramteke

Visvesvaraya National Institute of Technology, Nagpur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5578-86

5578-5586

424

212

4.

COMPARATIVE PHYSIOLOGICAL AND MOLECULAR RESPONSES OF A COMMON AROMATIC INDICA RICE CULTIVAR TO HIGH SALINITY WITH NON-AROMATIC INDICA RICE CULTIVAR

With a threshold of 3 DSM-1, rice is one of the crops that are most sensitive to salt. Salinity in agricultural areas is primarily brought on by the overuse of irrigation water that is overly salty. The early vegetative and seedling stages of rice are the most vulnerable to salt stress, followed by the reproductive phases. When osmotic stress inhibits root water uptake, too much salt in the soil h...

Varsha Jha and Bhaskar Choudhury *

Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, Khardaha, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5587-94

5587-5594

382

203

5.

HISTORICAL PERSPECTIVE OF LEAD POISONING AND THERAPEUTIC APPROACH OF GARLIC (ALLIUM SATIVUM) AGAINST VARIOUS HUMAN ALIMENTS

Lead comes in a category of toxic heavy metal which acts as a pollutant when present in high concentration in the environment and cause severe effects on the human body. Due to its continuous use its level increases and serves as a serious threat for the society.  Lungs and skin are the first organs which get affected by Lead toxicity. Lungs are the most important and sensitive part of human ther...

Veena Sharma * and Surabhi Gupta

Department of Bioscience and Biotechnology, Banasthali Vidyapith, Tonk, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5595-05

5595-5605

394

1322

6.

SCRUTINY ON MANAGEMENT OF OSTEOSARCOMA

Osteosarcoma begins in the long bones and occurs mainly in children and young adults but is also seen in an older population with a high mortality rate. Zinc beryllium silicate and beryllium oxide, radioactive agents like radium and some C-type viruses have a harsh impact on osteosarcoma. Genetic factors like changes in the p53 tumor suppressor gene, mutation in RECQL4 gene, WRN gene can contribut...

Deblina Pal, Arnab Chakraborty and Monisha Nath *

Department of Pharmaceutical Technology *, School of Medical Sciences, Adamas University, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5606-12

5606-5612

149

92

Research Articles

 
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7.

IN-VITRO ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF ARALIA CORDATA AND KALOPANAX SEPTEMLOBUS

The present study is aimed to compare the in-vitro antibacterial and antioxidant activities of Aralia cordata Thunberg and Kalopanax septemlobus (Thunb.) Koidzumi (Araliaceae). The antibacterial activity of the two plants was evaluated disc diffusion and minimal inhibition concentration (MIC) method against two Gram-positive bacteria and two Gram-negative bacteria. The tested ether and ethyl aceta...

Kyoung-Sun Seo and Kyeong Won Yun *

Department of Oriental Medicine Resources, Sunchon National University, Suncheon, Republic of Korea.

DOI: 10.13040/IJPSR.0975-8232.14(12).5613-18

5613-5618

383

209

8.

DEVELOPMENT OF NANOGEL OF OFLOXACIN FOR OCULAR DRUG DELIVERY

Multiple anatomical and physiological obstacles have always made ocular drug administration difficult. Different novel drug delivery systems, including nanogels, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ thermosensitive gels, have been developed to get around the barriers to improve ocular Bioavailability. For the encapsulation of vi...

Gopa Roy Biswas *, Pritam Dutta, Grihadeep Paul, Soumik Patra and Srijita Paul

Department of Pharmaceutics, Guru Nanak Institute of Pharmaceutical Science and Technology, 157/F Nilgunj Road, Panihati, Sodepur, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5619-32

5619-5632

362

234

9.

PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS FROM PINDA CONCANENSIS

The plant Pinda concanensis belongs to family apiaceae. It was native to the Western Ghats of India, but it is now becoming rare as a result of widespread usage of the seeds for their therapeutic properties. It is an annual herb with tuberous roots, which are eaten raw by local folklore. Apiaceae is the well-known aromatic plant family having beneficial uses in home remedies, abundance of phytoche...

K. S. Walvekar and M. S. Nimbalkar *

Department of Botany, Shivaji University, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5633-42

5633-5642

381

182

10.

CHARACTERIZING THE ADIPOKINES, INFLAMMATORY CYTOKINES RESPONSE IN ENDOTHELIAL DYSFUNCTION IN HIGH-FAT DIET AND SINGLE DOSE OF STZ IN WISTAR ALBINO RAT MODELS

Introduction: Endothelial dysfunction and diet-induced diabetes may be significantly impacted by changes in Adipokine and inflammatory cytokine secretion linked to obesity. Our study's objective was to determine the effect of a high-fat diet also on concentrations of leptin, adiponectin, as well as other inflammatory indicators in type 2 diabetes mellitus brought on by streptozotocin (STZ)-induced...

Tarannum Perampalli *, Lavanya Prathap and Salim Dhundasi

Department of Biochemistry, Research Scholar, Saveetha University, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5643-54

5643-5654

321

223

11.

EVALUATION OF BINDING AFFINITY OF THE SELECTED HERBAL BIO-ACTIVE COMPONENTS WITH THE ENZYME CYP- 17Α-HYDROXYLASE BY PCOS AMELIORATION ACTIVITY THROUGH MOLECULAR DOCKING IN- SILICO APPROACH

Polycystic ovarian syndrome (PCOS) known by its name can be correlated with Soothaga Vaayu in Siddha classical literature which is one of the most common forms of metabolic and endocrine disorders of women, with a high prevalence among the reproductive age group, often associated with obesity, hypertension, insulin resistance, diabetes mellitus, hyperinsulinemia and dyslipidemia. Current therapeut...

S. Ethel Shiny *, C. B. S. Bharath Christian and P. Gomathi

Department of Gunapadam Marunthiyal, Santhigiri Siddha Medical College, Kerala University of Health Sciences, Pothencode, Thiruvanathapuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5655-68

5655-5668

408

194

12.

HYDROGEN PEROXIDE SCAVENGING ACTIVITY OF OXAZOLE DERIVATIVES

The present study is reported the antioxidant activity of oxazole derivatives. Oxazole are five-member heterocyclic ring containing nitrogen and oxygen as a hetero atom. Due to binding with a wide spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions, oxazole-based molecules are becoming a kind of significant heterocyclic nucleus, which have recei...

Amol Pund, Vilas Ghawate * and Chetan Kedari

Mula Education Society’s College of Pharmacy, Sonai, Ahmednagar, Newasa, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5669-75

5669-5675

147

75

13.

PHARMACOGNOSTIC AND HPTLC COMPARISON OF KERALA MARKET SAMPLES OF BHARANGI (CHERUTHEK) WITH GENUINE SOURCE PLANT ROTHECA SERRATA (L.) STEANE & MABB

Background: Bhāraṅgī, herbal drug used in Ayurveda as Kapha-Vata samaka and indicated in Swasa, Kasa, Vrana, Shotha etc. It is an important ingredient in many of the preparations like Kantakaryavaleha, Kanakasava, Dasamularista, Lodhrasavam, Sudarsanasavam. As per API the accepted source of Bhāraṅgī is Rotheca serrata (L.) Steane & Mabb belongs to family Lamiaceae. There were ambient s...

A. Navami *, P. Vivek and C. M. Harinarayanan

Department of Dravyaguna Vijnana, VPSV Ayurveda College, Kottakkal, Malappuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5676-86

5676-5686

195

101

14.

IDENTIFYING TUBULIN AS A NEW TARGET OF A DIHYDROPYRIDINE DERIVATIVE, AMLODIPINE BESYLATE

The quest for new antimitotic drugs is an ongoing process where microtubules act as an attractive target for anti-cancer drugs. In this work, we report on the anti-cancer activity of Amlodipine besylate (AB), a salt derivative of the dihydropyridine groupdrug Amlodipine, a long-acting third-generation calcium channel blocker. Cytotoxicity assay revealed that AB demonstrated cytotoxic effects again...

Sampurna Bhattacharya, Ansuman Lahiri, Suvroma Gupta and Runa Sur *

Department of Biophysics, Molecular Biology and Bioinformatics, 92 A. P. C. Road, University of Calcutta, Kolkata, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5687-00

5687-5700

217

89

15.

A RETROSPECTIVE COMPARATIVE STUDY OF TOXICITIES AND OUTCOMES BETWEEN GEMCITABINE + NAB PACLITAXEL AND FOLFIRINOX IN LOCALLY ADVANCED CA PANCREAS RECEIVING IN NEO-ADJUVANT CHEMOTHERAPY

Neoadjuvant chemotherapy with Gemcitabine/nab-paclitaxel (Gemcitabine + Nab-Paclitaxel) And Folfirinox (Folfirinox) are two standard therapies for patients who has locally advanced pancreatic cancer (Lapc). We retrospectively compared the efficacy and safety of the two treatment regimens in patients with unresectable pancreatic cancer. The sample size consisted of 96 patients who has locally advan...

Khawaja Amtul Raouf Qazi *, Mariam Abdul Samad, Nazneen Kouser, Maveya Afreen, Shaikmusaib Zubedi and Anupama Koneru

Department of Pharmacy Practice, Sultan-ul-uloom College of Pharmacy, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5701-09

5701-5709

174

87

16.

HOMOEOPATHIC MANAGEMENT OF AN ACUTE CASE OF CERVICAL SPONDYLOSIS: A CASE REPORT

Introduction: Cervical spondylosis is a degenerative spine disorder commonly affecting the vertebrae and intervertebral discs in the cervical region. Most people commonly present with the complaint of neck pain at least once in their lifetime. It is, therefore, important to ascertain the cause responsible for it. Homoeopathy has a great scope in relieving the pain caused due to spondylosis, thereb...

R. B. Kulkarni, P. S. Aphale * and D. B. Sharma

Department of Homoeopathic Pharmacy, Dr. D.Y. Patil Homoeopathic Medical College & Research Centre, Dr. D.Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5701-15

5710-5715

235

120

17.

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF CLIMBAZOLE

Climbazole is a topical antifungal agent commonly used to treat human fungal skin infections such as dandruff and eczema. The goal of research work was to develop and validate a simple, precise, quick, and highly efficient UV spectrophotometric approach for quantifying Climbazole in bulk and shampoo dosage form. The quantification was completed using a twin beam UV spectrophotometer at 222 nm and ...

U. C. Galgatte, U. S. Desai *, D. H. Wani, Y. N. Tidake, R. V. Khorde and M. S. Borbane

Department of Pharmaceutics, Faculty of PES Modern College of Pharmacy, Nigdi, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5716-21

5716-5721

148

118

18.

PRIMARY AMENORRHEA WITH APLASTIC UTERUS, BILATERAL NON-COMMUNICATING RUDIMENTARY HORNS WITH HEMATOMETRA IN LEFT HORN AND CERVICOVAGINAL APLASIA (U5A C4 V4) – A RAREST CASE REPORT

Congenital uterine malformations account for 5.5 % of unselected population, while mullerian agenesis has an incidence of 1 in 4500-5000 females. Mullerian agenesis occurs due to embryological underdevelopment of mullerian duct with resultant agenesis or atresia of the vagina, uterus or both. We report a rare case of 22 year old female with primary amenorrhea with aplastic uterus with bilateral ru...

Ruby Bhatia, Kaveripatti Kannan Aishwarya * and Rahul Kalyanam

Department of Obstetrics and Gynaecology, MMIMSR, Mullana, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5722-24

5722-5724

133

73

19.

FORMULATION AND EVALUATION OF ANTIBACTERIAL HERBAL MOUTHWASH AGAINST ORAL DISORDERS

The current study aims to develop and evaluate herbal mouthwash and ascertain its effectiveness against microbes. Conventionally herbal mouthwashes are used as a disinfectant to lessen the presence of microbes in the oral cavity. Herbal mouthwashes act as a preventative agent for bleeding gums, decoloring teeth, and killing off bad breath germs. The herbal mouthwashes also have inherent benefits o...

M. Govardhan, B. Hemanth, M. Ricwin, G. K. Yuvan Shankar, K. Yuvaraj and T. P. Karunya *

Department of Biotechnology, Vel Tech High Tech Dr. Rangarajan Dr. Sakunthala Engineering College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5725-33

5725-5733

161

96

20.

THE ETHANOL EXTRACT OF EUPHORBIA HETEROPHYLLA PROTECTS LIVER CELLS AGAINST ETHANOL-INDUCED TOXICITY DUE TO ITS ANTIOXIDANT POTENTIALS IN WISTAR RATS

Background: The herbal drugs used in traditional medicine are proven more effective and safe compared to synthetic drugs for managing lifestyle diseases, including liver toxicity. Objective: The present investigation aimed to evaluate the hepatoprotective potentials of ethanol extract of Euphorbia heterophylla leaves against ethanol-induced liver damage in rats. Methodology: The acute oral toxicit...

D. Suja Rani *, C. Ramesh and Pinkey Rawal

Department of Pharmacology, East West College of Pharmacy, Bangalore, Karnataka, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5734-42

5734-5742

161

93

21.

CHARACTERISTICS OF INFLUENCE OF CLIMACTERIC SYNDROME ON ILLNESS COURSE IN PATIENTS WITH CHRONIC KIDNEY DISEASE 5th THE STAGE

Chronic kidney disease (CKD) is urgent problem, because its social and economic problem of society and medicine among the population in the world.About 850 million of the world's population suffer from various kidney diseases. Patients at the stage of CKD 5th stages may experience changes such as cardiovascular complications, uremic intoxication, severe anemia, phosphorus-calcium and other micronu...

S. N. Isirgapova *, M. A. Sabirov, N. N. Sultonov, M. KH. Tashpulatova and O. V. Skosireva

Tashkent State Dental Institute, St. Makhtumkuli 103, Tashkent, Uzbekistan.

DOI: 10.13040/IJPSR.0975-8232.14(12).5743-50

5743-5750

122

62

22.

BACTERIOPHAGE-MEDIATED MODULATION OF MULTIDRUG-RESISTANT PATHOGENS AND THEIR SUBSEQUENT ENCAPSULATION IN SODIUM ALGINATE MICROSPHERES

Antibiotic resistance is one of the gravest threats to human health today. Antibiotic resistance has emerged among hazardous bacteria due to the widespread use of drugs for human health, marine life, and agricultural animals. In contrast, bacteriophages are viruses that parasitize other bacteria for sustenance. A host cell is necessary for phage development and may be found practically everywhere ...

Sutripto Ghosh *, Tamalika Chakraborty, Quazi Sayeed Ahmad and Sharmistha Bhandari

Department of Biotechnology, Guru Nanak Institute of Pharmaceutical Science and Technology, Kolkata, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5751-59

5751-5759

129

66

23.

RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM BY QBD APPROACH

“Quality by Design” (QbD) serves as a bridge between industry and drug regulatory authorities to move towards a scientific, risk based holistic and proactive approach for development of pharmaceutical products. So, the present work describes the development of RP-HPLC method for simultaneous estimation of azelnidipine and telmisartan in pharmaceutical dosage form by QbD approach. The Box-Behnk...

R. S. Sakhare *, M. D. Padole, S. S. Tondare, A. H. Gaherwar, M. H. Muratkar and N. P. Savant

Department of Pharmaceutical Quality Assurance, Channabasweshwar Pharmacy College (Degree), Kava Road, Basweshwar Chowk, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5760-70

5760-5770

209

163

24.

COMPARISON OF EFFICACY OF TWO TYPES OF MUSIC PLAYED INTRA-OPERATIVELY AS AN ADJUNCT TO SPINAL ANESTHESIA FOR BETTER PERI-OPERATIVE EXPERIENCE OF THE PATIENT: A RANDOMISED CONTROL STUDY

Aim: To compare the effects of two types of music (meditation and devotional) played intra-operatively and control (no music) as an adjunct to spinal anaesthesia for better and holistic approach to perioperative care of the patient. Methodology: A prospective, randomised control study was conducted at a tertiary care hospital with 60 patients. The patients were randomly allocated into three groups...

Rohit Kamal, Beulah Shekinah Elango *, V. S. G. Yachendra, N. Latha, Arun Prasath and R. Lakshmi

Department of Anaesthesiology, Saveetha Medical College and Hospital, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5771-80

5771-5780

134

76

25.

DEVELOPMENT AND VALIDATION OF SECOND-ORDER DERIVATIVE UV SPECTROPHOTOMETRIC ESTIMATION OF FAVIPIRAVIR ANTIVIRAL DRUG

Objectives: The present study aims to develop a simple, precise, accurate, and reproducible spectrophotometric Second order derivative method for estimating Favipiravir in bulk and pharmaceutical dosage form. Method: Acetonitrile was used as an organic solvent. The maximum absorption of the drug was found to be at 323nm. The developed method was validated and applied for the estimation of Favipira...

Pallavi V. Duse *, V. G. Thakur, T. D. Pingale, N. S. Laxane and S. A. Choudhari

Department of Pharmacy, VIVA Institute of Pharmacy, Shirgaon, Virar (East), Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5781-84

5781-5784

156

77

26.

IN-SILICO DESIGN OF FLUTAMIDE ANALOGUES AS ANDROGEN RECEPTOR ANTAGONIST AND MOLECULAR DOCKING STUDIES

Androgenic hormones such as testosterone and dihydrotestosterone are essential for the progression of the prostate gland. Overexpression of androgenic receptors is responsible for the proliferation of prostate tumours and androgenic receptors are an essential target in prostate cancer therapy. Flutamide was the first Nonsteroidal androgen receptor antagonist used to treat prostate cancer, but it c...

Ajay Kumar Gupta, Achal Mishra and Sanmati Kumar Jain *

Drug Discovery and Research Laboratory, Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur, Chhattisgarh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5785-01

5785-5801

145

80

27.

IN-VITRO CULTURE OF ETHNOMEDICINAL ENDANGERED PLANT CALLIGONUM POLYGONOIDES (PHOG) LINN.

This study mainly focusses on survey, conservation and awareness of ethno-medicinal plants in the Thar desert area of Barmer. Calligonum polygonoides Linn was collected from Thar Desert region of Malana village of Barmer district, locally known as “PHOG” and “PHOGRA” and belongs to Polygonaceae family. The rareness of the plant showed need for its micropropagation. Survey was conducted in ...

Akhatar Khan, Saroj Kumari and Aparna Pareek *

Department of Botany, University of Rajasthan, Jaipur, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5802-10

5802-5810

130

79

28.

ANTIMICROBIAL METABOLITE PRODUCTION BY KOCURIA ASSAMENSIS VLS-2 ISOLATED FROM SOUTH-COASTAL REGIONS OF ANDHRA PRADESH, INDIA

An attempt was made to identify actinomycete strains of the South coastal region of Andhra Pradesh, India along with the study of their antimicrobial potential. Among the 50 actinomycete strains isolated, one strain (VLS-2) showed strong antimicrobial activity against Gram-positive and Gram-negative bacteria as well as fungi. It was identified as Kocuria assamensis based on morphological, biochemi...

Mary Swapna Mogili and Muvva Vijayalakshmi *

Department of Botany and Microbiology, Acharya Nagarjuna University, Guntur, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5811-23

5811-5823

143

70

29.

ULTRASOUND SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES OF FE (III) COMPLEXES OF Β-DIKETONES

Consistently the preparation of transition metal complexes of β-diketones has been (and it still is) an area of the highest interest for inorganic and organic chemists, as can be inferred considering the quantity and diversity of research developed in this field. 1,3- Diketones are  wide range of valuable molecules including several types of carbocycles and heterocycles hence have high interest....

Aakash S. Singare, Jaiprakash S. Dargad and Nanda S. Korde *

Department of Chemistry & Industrial Chemistry, Dayanand Science College, Latur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5824-30

5824-5830

220

72

30.

ANALYSIS AND REPORTING OF ADVERSE DRUG REACTIONS AT A TERTIARY CARE TEACHING HOSPITAL IN MEWAT REGION OF NORTHERN INDIA

Introduction: Adverse drug reactions (ADRs) poses an unforeseeable menace associated with all the prescribed medicines. Thus, ADRs are monitored and assessed on a large scale in our country by the Pharmacovigilance Programme of India through adverse drug reaction monitoring centres (AMCs). Objectives: This study was done to assess the pattern of ADRs reported in a tertiary care teaching hospital i...

Abhimanyu Vohra, Naveen Kumar, Siddharth Ahuja, Navin Budania * and V. K. Bharadwaj

Department of Pharmacology, Shaheed Hasan Khan Mewati Government Medical College, Nalhar, Nuh, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5831-40

5831-5840

142

80

31.

HOMOEOPATHIC MANAGEMENT OF DECUBITUS ULCER: A CASE REPORT

Decubitus ulcers continue to be a common health problem, particularly among the physically limited or bedridden. Decubitus ulcers may develop into chronic conditions for no apparent reason, persist for prolonged periods, or even last the patient's entire life. Modern medicine mainly serves in managing ulcer wounds through superficial wound cleaning and dressing. But it takes time for healing of de...

Y. A. Airan, P. S. Aphale * and D. B. Sharma

Department of Homoeopathic Pharmacy, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5841-45

5841-5845

162

86

32.

EFFICACY OF PSORINUM IN CHRONIC URTICARIA: A CASE REPORT

Chronic urticaria is a popular skin complaint that is characterized by wheals of various sizes surrounded by erythema and associated with itching and burning as a consequence of Type1 hypersensitivity reaction mediated by IgE antibodies to specific allergen. Most of the population (>20%) have urticaria once somewhere in the life. The conventional management of this condition is associated with ...

S. Singh * and R. Sangtani

Department of Homoeopathic Materia Medica, Dr. D. Y. Patil Homoeopathic Medical College and Research Centre, Pimpri, Pune, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5846-52

5846-5852

147

102

33.

DRUG UTILIZATION PATTERN AND DISEASE PROGRESSION IN HOSPITALIZED PATIENTS WITH COVID-19

Background: The WHO declared the coronavirus disease 2019 (COVID-19) outbreak as a global pandemic in March 2020. Since, no specific drugs are currently available for its treatment it is important to document the prescription patterns. Objectives: To evaluate the drug prescribing pattern and assess the disease progression in the patients hospitalized with COVID-19 in a tertiary care hospital. Meth...

Sarajita Barman, Riturag Thakuria, Dolly Roy and Rohit Tigga *

Department of Pharmacology, Silchar Medical College and Hospital, Silchar, Assam, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5853-60

5853-5860

156

80

34.

IN-SILICO IDENTIFICATION OF NEWER POTENTIAL LEMUR TYROSINE KINASE 3 INHIBITORS FOR THE TREATMENT OF BREAST CANCER

Breast cancer refers to cancer emerging from breast tissue, commonly from the lobules that supply the ducts with milk or from the inner linings of milk ducts. Due to the mutation of DNA or RNA from the normal cells and abnormal genes when inherited, cancer cells are evolved. LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of dise...

R. Priyadarsini *, M. Ashokan, N. Bright Lemuel John, R. Harshita, P. Kokila and P. Madhumitha

Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5861-79

5861-5879

178

122

35.

FORMULATION AND EVALUATION OF POLYHERBAL IN-SITU GEL FOR GLAUCOMA

Worldwide, glaucoma is the second most important cause of blindness and irreversible vision loss. Raised IOP (Intraocular Pressure) is not always a mark of glaucoma; it is a key risk factor and a cause of glaucomatous optic neuropathy. Herbal preparations have various active and inactive compounds which are not standardized likewise, Camellia sinensis and Areca catechu having various active consti...

R. Jarag, R. Jarag and G. Dhule *

Department of Pharmaceutics, Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5880-94

5880-5894

153

85

36.

COMPARATIVE STUDY OF ANTI-AGGREGATION PROPERTY OF LEAF PROTEINS OF BRAHMI, FENUGREEK AND TRIDAX ON THE FORMATION OF LYSOZYME AMYLOID FIBRILS

Lysozyme amyloid formation is studied as model in-vitro system to find out natural or synthetic inhibitors of amyloidosis. Protein aggregation and amyloid formation is the basic reason for many neurodegenerative diseases. Indigenous medicinal plants are great source of therapeutic molecules and drugs. Ethnobotanical studies have indicated many plants have neuroprotective functions. We have studied...

Sayantan Sil, Sudip Kumar Nag, Labani Hazra and Srabani Karmakar *

Kingston College of Science, Barasat, Berunanpukuria, West Bengal, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5895-01

5895-5901

146

75

37.

PHYTOCONSTITUENT ANALYSIS AND IN-VITRO ANTI-INFLAMMATORY ACTIVITIES OF PLANTS SOURCES

Bioactive compounds are secondary plant metabolites and are found in small amounts in plants, fruit, vegetables, and edible oils; they have health benefits and provide us an alternative search for drugs or medicines and followed by the minimum side effects. There are various bioactive assays for measuring the functional activities of bioactive compounds, such as phytochemical assays and anti-infla...

K. Nirmala and Veerendra Kumar Bapatla *

Department of Biotechnology, GITAM School of Sciences, GITAM University, Visakhapatnam, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5902-08

5902-5908

145

80

38.

IN-VITRO PHOTOPROTECTIVE EFFECT OF AN ACTINOMYCETE DERIVED MELANIN AGAINST MELANOMA

Actinomycetes are biotechnologically important microorganism as they produce many secondary metabolites and natural pigments, including a dark-brown pigment melanin. Melanin is produced in melanocytes that provides pigmentation to skin. Although many roles have been attributed to melanic pigments, the main role in nature seems to be photoprotection damage. Melanin possesses anti- UV radiation prop...

E. Devika, S. Gayathri, V. Swarnalakshmi and A. Vidhya *

Department of Microbiology, D. K. M. College for Women, Vellore, Tamil Nadu, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5909-15

5909-5915

148

86

39.

FORMULATION AND EVALUATION OF CURCUMIN-LOADED CHITOSAN NANOPARTICLES AND ITS INTRANASAL EFFICACY FOR CNS DELIVERY

Hydrophobic medications that are taken orally having poor bioavailability due to permeability issues. They experience a chemical and enzymatic breakdown in the digestive system and exhibit a significant amount of hepatic first-pass metabolism. Similar obstacles prevent the development of effective therapeutic molecule delivery systems and the discovery of new drugs. It has been revealing that curc...

Lucky Mangal *, Nitin Kaushik and Sanjar Alam

Department of Pharmaceutics, R. V. Northland Institute, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5916-29

5916-5929

134

83

41.

FORMULATION AND EVALUATION OF VALSARTAN NANO-EMULSION FOR ITS TRANSDERMAL EFFICACY

Valsartan is a selective angiotensin type I receptor agonist that has been used in the treatment of hypertension disease. The development of a thermodynamically stable and infinitely dilutable nanoemulsion (O/W) of valsartan with surfactant at a low concentration that can enhance its solubility and stability came about as a result of our investigation into the effectiveness of nanoemulsion as a ca...

Nitin Kaushik *, Lucky Mangal and Sanjar Alam

Department of Pharmaceutics, R. V. Northland Institute, Greater Noida, Uttar Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5930-43

5930-5943

148

95

41.

QUALITY ANALYSIS OF MARKET SAMPLES OF ŌRILA COLLECTED FROM DIFFERENT MARKETS OF KERALA USING PHARMACOGNOSTIC TOOLS

Ōrila is a well-known drug used in many Ayurvedic recipes in kerala. In most texts Ōrilais seen paired with Mūvilaand together they fare as components of the Daśamula. From very old Kerala commentaries of ancient Ayurvedic texts, Ōrila and Mūvila are seen as Malayalam translations of Pṛśniparṇī and Śālaparṇī respectively. In Kerala Pṛśniparṇīis often identified as Ōrila and...

A. A. Athira *, K. P. Madhu and C. M. Harinarayanan

Department of Dravyaguna Vijnana, VPSV Ayurveda College, Kottakkal, Malappuram, Kerala, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5944-64

5944-5964

205

89

42.

EVALUATION OF IN-VITRO ANTHELMENTIC ACTIVITY OF BETA VULGARIS

Plant products are of increasing interest in the search for new drugs and medicines in the treatment of diseases; and the discovery of new alternatives to existing commercially available drugs is an important area of this research due to pathogen resistance. The present investigation focused on the screening of anthelmintic potential of pet-ether, benzene, ethanol and aqueous extracts of the plant...

Karra Geetha *, Sheri Sunitha, R. Shireesh Kiran and G. S. Sharma

CMR College of Pharmacy, Kandlakoya, Medchal, Hyderabad, Telangana, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5965-69

5965-5969

146

74

43.

EVALUATION OF THE EFFECTIVENESS OF THE EFFECT OF ACETYLCYSTEINE ON INTRARENAL HEMODYNAMICS IN PATIENTS WITH CORONAVIRUS ASSOCIATED NEPHROPATHY

This article discusses the assessment of kidney function in patients with coronavirus-associated nephropathy through Doppler ultrasound of renal vessels. The study focuses on research groups comprising individuals affected by this nephropathy. Dopplerography studies aim to evaluate the effectiveness of N-acetylcysteine in treating coronavirus-associated nephropathy. Doppler ultrasound helps assess...

M. H. Tashpulatova *, M. A. Sabirov, B. A. Munavvarov, S. U. Shadieva and N. R. Babajanova

Hostel Tashkent State Dental Institute, Tashkent 100187, Uzbekistan.

DOI: 10.13040/IJPSR.0975-8232.14(12).5970-76

5970-5976

158

80

44.

EFFECTIVENESS OF INJECTION TERIPARATIDE IN OSTEOPOROTIC INTERTROCHANTERIC FRACTURE TREATED WITH PROXIMAL FEMUR NAILING

Introduction: Osteoporosis is relatively a serious medical condition causing geriatric trauma, which leads to an increase in morbidity and mortality. Early fracture union is important for early mobilization and for good functional outcome. Recombinant parathyroid hormone has shown to accelerate the fracture union and improve the functional outcome. Therefore, in this study we have decided to evalu...

Pillai Divya Radhakrishna, A. Vinayagamoorthy, T. Pradeepkumar *, R. Surendherkumar and A. Subramanian

Department of Orthopaedics, Mahatma Gandhi Medical College & Research Institute, Pillayarkuppam, Puducherry, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5977-84

5977-5984

178

100

45.

ANTIDIABETIC POTENTIAL OF PROTEIN AND FIBER RICH MILLET BASED SNACK BAR

Diabetes mellitus has become a global concern with 422 million people affected due to this disease. As the oral hypoglycaemic drugs available in the market have their own set of side effects which can be one of the primary factors towards non-adherence of these medicines among patients, we must explore some natural alternatives in order to deal with this disease in an efficient manner. In such sce...

Soumya Singh * and Komal Chauhan

National Institute of Food Technology Entrepreneurship and Management, Sonipat, Haryana, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5985-93

5985-5993

141

108

46.

DEVELOPMENT OF VALIDATED HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF FERULIC ACID AND ELLAGIC ACID

A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of ellagic acid and ferulic acid in herbal formulation. Quantification was carried out with pre-coated silica gel aluminium plate G60F254 (10x10cm) as stationary phase, mobile phase consisting of Ethyl acetate: toluene: formic acid: methanol (3.5:...

V. M. Jadhav *, V. J. Kadam, S. S. Pawar and A. R. Khobarekar

Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).5994-99

5994-5999

151

90

47.

SCREENING OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF GLORIOSA SUPERBA IN RODENTS

Background: Traditionally Gloriosa superba is being used as a medicinal plant in outskirts of belagavi, we evaluated and compared the analgesic and anti-inflammatory activities of hydroalcoholic extract of dried aerial parts (rhizomes) of G. superba with standard drugs. Methods: This experimental animal study was carried out in the Research Laboratory, Department of Pharmacology, BIMS, Belagavi. P...

B. Srinivasa, Basavaraj C. Kotinatot, Aruna Bushan and P. Madhav *

Department of Pharmacology, Apollo Institute of Medical Sciences and Research, Chittoor, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).6000-07

6000-6007

149

73

48.

HPTLC METHOD DEVELOPMENT AND VALIDATION FOR HYDROXYCHAVICOL ISOLATED FROM PIPER BETEL LEAVES

A simple, precise, accurate, and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of hydroxychavicol isolated from piper betel leaves powder. The isolation of hydroxychavicol was carried out using flash chromatography. Validation was carried out with pre-coated silica gel aluminum plate G 60 F254 (10 x 10 cm) as the stationary ...

V. M. Jadhav *, V. J. Kadam, A. R. Khobarekar and S. S. Pawar

Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, University of Mumbai, Navi Mumbai, Maharashtra, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).6008-13

6008-6013

170

88

49.

PHYTOCHEMICAL & PHYSIOCHEMICAL SCREENING OF THE HERBAL DRUG ALOEVERA AND CLITORIA TERNATEA LEAVES EXTRACT

Egyptians referred to aloe vera, a botanical remedy, as "the plant of immortality." It helps with diabetes, hypertension, wound healing, and other medical conditions. Aloe vera gel extract and Clitoria ternatea watery, methanolic, and ethanolic extracts of plants was studied. A small sample of Aloe vera and Clitoria ternatea's ethanolic, methanolic, and watery extracts were put through a phytochem...

Raghuvendra Singh * and M. K. Gupta

Career Point School of Pharmacy, Career Point University, NH 52, Opp. Alaniya Mata Ji Mandit, Alaniya, Kota, Rajasthan, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).6014-21

6014-6021

135

81

50.

ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICES OF ADVERSE DRUG REACTION REPORTING AMONG NURSING STAFF OF TERTIARY CARE TEACHING HOSPITAL IN WESTERN RURAL INDIA

Introduction: Underreporting of adverse drug reactions (ADRs) in Pharmacovigilance programme of India (PvPI) may be due to lack of adequate knowledge, attitude and practice among healthcare professionals towards ADR reporting. Aim & Objective: Present study was planned to assess the knowledge, attitude and practices of ADR reporting amongst nursing staff of tertiary teaching hospital in Wester...

Tushar C. Baheti, Poonam Malani, Tanu Garg and Rekha Mehani *

Department of Pharmacology, People’s College of Medical Sciences & Research Centre, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.15(12).6022-28

6022-6028

140

82

51.

FORMULATION AND EVALUATION OF SUSTINED RELEASE MATRIX TABLET OF METRONIDAZOLE

In this study matrix tablets of metronidazole were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F9). The mean hardness values were measured for all the formulation usin...

Ravindra Kumar Shah and Gopal Patel *

Sagar Institute of Pharmacy and Technology, Gandhi Nagar Campus Opposite International Airport, Bhopal, Madhya Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).6029-37

6029-6037

158

99

52.

METHOD DEVELOPMENT AND VALIDATION USING HPLC-ESI-MS/MS FOR DETERMINING STABILITY OF TALAZOPARIB IN BIOLOGICAL MATRICES

A highly sensitive, simple, accurate and precise HPLC-ESI-MS/MS method was developed and validated for the quantitative determination of talazoparib in biological matrices. The present study describes the determination of Talazoparib using validated protein precipitation method from human plasma employing Talazoparib 13C D4 as internal standard by electron spray ionization technique. Combination o...

K. Poorna Chandra Rao * and K. R. S. Sambasiva Rao

Jawaharlal Nehru Technological University, JNTUK, Kakinada, Andhra Pradesh, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).6038-43

6038-6043

127

73

53.

ANTIPYRETIC ACTIVITY STUDY OF SARCOSTEMMA ACIDUM VOIGT

Sarcostemma acidum Voigt is a xerophytic plant of the family Apocynaceae. Plant is locally known as Somlata. It is a traditional medicinal plant used to prepare Somras. The plant is mainly found in Bihar, West Bengal, Odisha and South India. It is mostly grown in dry rocky places. S. acidum is a shrub, more branched but no leaves. The stems are jointed with each other. These are green, cylindrical...

Pravanjan Kumar Tripathy * and Manas Ranjan Mishra

Biju Patnaik University of Technology, Rourkela, Odisha, India.

DOI: 10.13040/IJPSR.0975-8232.14(12).6044-47

6044-6047

124

68