Volume 14 (2023) - Issue 12, December
Review Articles
IN-VIVO MODELS OF NON-ALCOHOLIC FATTY LIVER DISEASE
Non-alcoholic fatty liver disease (NAFLD), a common chronic liver condition, is high in developed nations. One of the factors leading to chronic liver disease and cryptogenic cirrhosis has been identified as NAFLD. Multiple risk factors, including obesity, insulin resistance, diabetes mellitus, hyperlipidemia, and hypertension-related cardiovascular disease, contribute to the development of NAFLD....
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AN EXTENSIVE REVIEW ON EFFECTS OF PSYCHOBIOTIC BASED TREATMENTS IN AUTISTIC SPECTRUM OF DISORDER AND APPLICABILITY OF ZEBRAFISH AS A ROBUST MODEL FOR STUDYING ASD
Autism spectrum disorders (ASDs) refer to the group of neuropsychiatric disorders that alter neurodevelopment and mental function and are characterised by an extensive range of symptoms, including hyper-or hyposensitivity, repetitive behaviours, and impairments in social and academic functioning. Untangling the causation of ASD has been complicated, in part because distinct genetic abnormalities ...
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CURRENT LANDSCAPE FROM CLINICAL TRIALS AND FUTURE OF COMBINED CHECKPOINTS BLOCKADE IMMUNOTHERAPY IN CANCERS
Immunotherapy is among cancer immunology's fastest and most furious treatment strategies. The therapeutic perspective of checkpoint inhibitors is represented through the Food and Drug Administration (FDA) approvals for their implementation in various malignancies. Efforts to improve results with immunotherapeutic agents have led to the design of advanced treatment strategies. Current pre-clinical ...
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COMPARATIVE PHYSIOLOGICAL AND MOLECULAR RESPONSES OF A COMMON AROMATIC INDICA RICE CULTIVAR TO HIGH SALINITY WITH NON-AROMATIC INDICA RICE CULTIVAR
With a threshold of 3 DSM-1, rice is one of the crops that are most sensitive to salt. Salinity in agricultural areas is primarily brought on by the overuse of irrigation water that is overly salty. The early vegetative and seedling stages of rice are the most vulnerable to salt stress, followed by the reproductive phases. When osmotic stress inhibits root water uptake, too much salt in the soil h...
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HISTORICAL PERSPECTIVE OF LEAD POISONING AND THERAPEUTIC APPROACH OF GARLIC (ALLIUM SATIVUM) AGAINST VARIOUS HUMAN ALIMENTS
Lead comes in a category of toxic heavy metal which acts as a pollutant when present in high concentration in the environment and cause severe effects on the human body. Due to its continuous use its level increases and serves as a serious threat for the society. Lungs and skin are the first organs which get affected by Lead toxicity. Lungs are the most important and sensitive part of human ther...
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SCRUTINY ON MANAGEMENT OF OSTEOSARCOMA
Osteosarcoma begins in the long bones and occurs mainly in children and young adults but is also seen in an older population with a high mortality rate. Zinc beryllium silicate and beryllium oxide, radioactive agents like radium and some C-type viruses have a harsh impact on osteosarcoma. Genetic factors like changes in the p53 tumor suppressor gene, mutation in RECQL4 gene, WRN gene can contribut...
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Research Articles
IN-VITRO ANTIBACTERIAL AND ANTIOXIDANT ACTIVITIES OF ARALIA CORDATA AND KALOPANAX SEPTEMLOBUS
The present study is aimed to compare the in-vitro antibacterial and antioxidant activities of Aralia cordata Thunberg and Kalopanax septemlobus (Thunb.) Koidzumi (Araliaceae). The antibacterial activity of the two plants was evaluated disc diffusion and minimal inhibition concentration (MIC) method against two Gram-positive bacteria and two Gram-negative bacteria. The tested ether and ethyl aceta...
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DEVELOPMENT OF NANOGEL OF OFLOXACIN FOR OCULAR DRUG DELIVERY
Multiple anatomical and physiological obstacles have always made ocular drug administration difficult. Different novel drug delivery systems, including nanogels, nanoparticles, liposomes, dendrimers, implants, contact lenses, nanosuspensions, microneedles, and in situ thermosensitive gels, have been developed to get around the barriers to improve ocular Bioavailability. For the encapsulation of vi...
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PHYTOCHEMICAL SCREENING AND GC-MS ANALYSIS OF BIOACTIVE COMPOUNDS FROM PINDA CONCANENSIS
The plant Pinda concanensis belongs to family apiaceae. It was native to the Western Ghats of India, but it is now becoming rare as a result of widespread usage of the seeds for their therapeutic properties. It is an annual herb with tuberous roots, which are eaten raw by local folklore. Apiaceae is the well-known aromatic plant family having beneficial uses in home remedies, abundance of phytoche...
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CHARACTERIZING THE ADIPOKINES, INFLAMMATORY CYTOKINES RESPONSE IN ENDOTHELIAL DYSFUNCTION IN HIGH-FAT DIET AND SINGLE DOSE OF STZ IN WISTAR ALBINO RAT MODELS
Introduction: Endothelial dysfunction and diet-induced diabetes may be significantly impacted by changes in Adipokine and inflammatory cytokine secretion linked to obesity. Our study's objective was to determine the effect of a high-fat diet also on concentrations of leptin, adiponectin, as well as other inflammatory indicators in type 2 diabetes mellitus brought on by streptozotocin (STZ)-induced...
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EVALUATION OF BINDING AFFINITY OF THE SELECTED HERBAL BIO-ACTIVE COMPONENTS WITH THE ENZYME CYP- 17Α-HYDROXYLASE BY PCOS AMELIORATION ACTIVITY THROUGH MOLECULAR DOCKING IN- SILICO APPROACH
Polycystic ovarian syndrome (PCOS) known by its name can be correlated with Soothaga Vaayu in Siddha classical literature which is one of the most common forms of metabolic and endocrine disorders of women, with a high prevalence among the reproductive age group, often associated with obesity, hypertension, insulin resistance, diabetes mellitus, hyperinsulinemia and dyslipidemia. Current therapeut...
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HYDROGEN PEROXIDE SCAVENGING ACTIVITY OF OXAZOLE DERIVATIVES
The present study is reported the antioxidant activity of oxazole derivatives. Oxazole are five-member heterocyclic ring containing nitrogen and oxygen as a hetero atom. Due to binding with a wide spectrum of receptors and enzymes easily in biological systems through various non-covalent interactions, oxazole-based molecules are becoming a kind of significant heterocyclic nucleus, which have recei...
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PHARMACOGNOSTIC AND HPTLC COMPARISON OF KERALA MARKET SAMPLES OF BHARANGI (CHERUTHEK) WITH GENUINE SOURCE PLANT ROTHECA SERRATA (L.) STEANE & MABB
Background: Bhāraṅgī, herbal drug used in Ayurveda as Kapha-Vata samaka and indicated in Swasa, Kasa, Vrana, Shotha etc. It is an important ingredient in many of the preparations like Kantakaryavaleha, Kanakasava, Dasamularista, Lodhrasavam, Sudarsanasavam. As per API the accepted source of Bhāraṅgī is Rotheca serrata (L.) Steane & Mabb belongs to family Lamiaceae. There were ambient s...
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IDENTIFYING TUBULIN AS A NEW TARGET OF A DIHYDROPYRIDINE DERIVATIVE, AMLODIPINE BESYLATE
The quest for new antimitotic drugs is an ongoing process where microtubules act as an attractive target for anti-cancer drugs. In this work, we report on the anti-cancer activity of Amlodipine besylate (AB), a salt derivative of the dihydropyridine groupdrug Amlodipine, a long-acting third-generation calcium channel blocker. Cytotoxicity assay revealed that AB demonstrated cytotoxic effects again...
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A RETROSPECTIVE COMPARATIVE STUDY OF TOXICITIES AND OUTCOMES BETWEEN GEMCITABINE + NAB PACLITAXEL AND FOLFIRINOX IN LOCALLY ADVANCED CA PANCREAS RECEIVING IN NEO-ADJUVANT CHEMOTHERAPY
Neoadjuvant chemotherapy with Gemcitabine/nab-paclitaxel (Gemcitabine + Nab-Paclitaxel) And Folfirinox (Folfirinox) are two standard therapies for patients who has locally advanced pancreatic cancer (Lapc). We retrospectively compared the efficacy and safety of the two treatment regimens in patients with unresectable pancreatic cancer. The sample size consisted of 96 patients who has locally advan...
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HOMOEOPATHIC MANAGEMENT OF AN ACUTE CASE OF CERVICAL SPONDYLOSIS: A CASE REPORT
Introduction: Cervical spondylosis is a degenerative spine disorder commonly affecting the vertebrae and intervertebral discs in the cervical region. Most people commonly present with the complaint of neck pain at least once in their lifetime. It is, therefore, important to ascertain the cause responsible for it. Homoeopathy has a great scope in relieving the pain caused due to spondylosis, thereb...
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ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF CLIMBAZOLE
Climbazole is a topical antifungal agent commonly used to treat human fungal skin infections such as dandruff and eczema. The goal of research work was to develop and validate a simple, precise, quick, and highly efficient UV spectrophotometric approach for quantifying Climbazole in bulk and shampoo dosage form. The quantification was completed using a twin beam UV spectrophotometer at 222 nm and ...
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PRIMARY AMENORRHEA WITH APLASTIC UTERUS, BILATERAL NON-COMMUNICATING RUDIMENTARY HORNS WITH HEMATOMETRA IN LEFT HORN AND CERVICOVAGINAL APLASIA (U5A C4 V4) – A RAREST CASE REPORT
Congenital uterine malformations account for 5.5 % of unselected population, while mullerian agenesis has an incidence of 1 in 4500-5000 females. Mullerian agenesis occurs due to embryological underdevelopment of mullerian duct with resultant agenesis or atresia of the vagina, uterus or both. We report a rare case of 22 year old female with primary amenorrhea with aplastic uterus with bilateral ru...
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FORMULATION AND EVALUATION OF ANTIBACTERIAL HERBAL MOUTHWASH AGAINST ORAL DISORDERS
The current study aims to develop and evaluate herbal mouthwash and ascertain its effectiveness against microbes. Conventionally herbal mouthwashes are used as a disinfectant to lessen the presence of microbes in the oral cavity. Herbal mouthwashes act as a preventative agent for bleeding gums, decoloring teeth, and killing off bad breath germs. The herbal mouthwashes also have inherent benefits o...
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THE ETHANOL EXTRACT OF EUPHORBIA HETEROPHYLLA PROTECTS LIVER CELLS AGAINST ETHANOL-INDUCED TOXICITY DUE TO ITS ANTIOXIDANT POTENTIALS IN WISTAR RATS
Background: The herbal drugs used in traditional medicine are proven more effective and safe compared to synthetic drugs for managing lifestyle diseases, including liver toxicity. Objective: The present investigation aimed to evaluate the hepatoprotective potentials of ethanol extract of Euphorbia heterophylla leaves against ethanol-induced liver damage in rats. Methodology: The acute oral toxicit...
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CHARACTERISTICS OF INFLUENCE OF CLIMACTERIC SYNDROME ON ILLNESS COURSE IN PATIENTS WITH CHRONIC KIDNEY DISEASE 5th THE STAGE
Chronic kidney disease (CKD) is urgent problem, because its social and economic problem of society and medicine among the population in the world.About 850 million of the world's population suffer from various kidney diseases. Patients at the stage of CKD 5th stages may experience changes such as cardiovascular complications, uremic intoxication, severe anemia, phosphorus-calcium and other micronu...
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BACTERIOPHAGE-MEDIATED MODULATION OF MULTIDRUG-RESISTANT PATHOGENS AND THEIR SUBSEQUENT ENCAPSULATION IN SODIUM ALGINATE MICROSPHERES
Antibiotic resistance is one of the gravest threats to human health today. Antibiotic resistance has emerged among hazardous bacteria due to the widespread use of drugs for human health, marine life, and agricultural animals. In contrast, bacteriophages are viruses that parasitize other bacteria for sustenance. A host cell is necessary for phage development and may be found practically everywhere ...
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RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF AZELNIDIPINE AND TELMISARTAN IN PHARMACEUTICAL DOSAGE FORM BY QBD APPROACH
“Quality by Design” (QbD) serves as a bridge between industry and drug regulatory authorities to move towards a scientific, risk based holistic and proactive approach for development of pharmaceutical products. So, the present work describes the development of RP-HPLC method for simultaneous estimation of azelnidipine and telmisartan in pharmaceutical dosage form by QbD approach. The Box-Behnk...
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COMPARISON OF EFFICACY OF TWO TYPES OF MUSIC PLAYED INTRA-OPERATIVELY AS AN ADJUNCT TO SPINAL ANESTHESIA FOR BETTER PERI-OPERATIVE EXPERIENCE OF THE PATIENT: A RANDOMISED CONTROL STUDY
Aim: To compare the effects of two types of music (meditation and devotional) played intra-operatively and control (no music) as an adjunct to spinal anaesthesia for better and holistic approach to perioperative care of the patient. Methodology: A prospective, randomised control study was conducted at a tertiary care hospital with 60 patients. The patients were randomly allocated into three groups...
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DEVELOPMENT AND VALIDATION OF SECOND-ORDER DERIVATIVE UV SPECTROPHOTOMETRIC ESTIMATION OF FAVIPIRAVIR ANTIVIRAL DRUG
Objectives: The present study aims to develop a simple, precise, accurate, and reproducible spectrophotometric Second order derivative method for estimating Favipiravir in bulk and pharmaceutical dosage form. Method: Acetonitrile was used as an organic solvent. The maximum absorption of the drug was found to be at 323nm. The developed method was validated and applied for the estimation of Favipira...
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IN-SILICO DESIGN OF FLUTAMIDE ANALOGUES AS ANDROGEN RECEPTOR ANTAGONIST AND MOLECULAR DOCKING STUDIES
Androgenic hormones such as testosterone and dihydrotestosterone are essential for the progression of the prostate gland. Overexpression of androgenic receptors is responsible for the proliferation of prostate tumours and androgenic receptors are an essential target in prostate cancer therapy. Flutamide was the first Nonsteroidal androgen receptor antagonist used to treat prostate cancer, but it c...
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IN-VITRO CULTURE OF ETHNOMEDICINAL ENDANGERED PLANT CALLIGONUM POLYGONOIDES (PHOG) LINN.
This study mainly focusses on survey, conservation and awareness of ethno-medicinal plants in the Thar desert area of Barmer. Calligonum polygonoides Linn was collected from Thar Desert region of Malana village of Barmer district, locally known as “PHOG” and “PHOGRA” and belongs to Polygonaceae family. The rareness of the plant showed need for its micropropagation. Survey was conducted in ...
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ANTIMICROBIAL METABOLITE PRODUCTION BY KOCURIA ASSAMENSIS VLS-2 ISOLATED FROM SOUTH-COASTAL REGIONS OF ANDHRA PRADESH, INDIA
An attempt was made to identify actinomycete strains of the South coastal region of Andhra Pradesh, India along with the study of their antimicrobial potential. Among the 50 actinomycete strains isolated, one strain (VLS-2) showed strong antimicrobial activity against Gram-positive and Gram-negative bacteria as well as fungi. It was identified as Kocuria assamensis based on morphological, biochemi...
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ULTRASOUND SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITIES OF FE (III) COMPLEXES OF Β-DIKETONES
Consistently the preparation of transition metal complexes of β-diketones has been (and it still is) an area of the highest interest for inorganic and organic chemists, as can be inferred considering the quantity and diversity of research developed in this field. 1,3- Diketones are wide range of valuable molecules including several types of carbocycles and heterocycles hence have high interest....
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ANALYSIS AND REPORTING OF ADVERSE DRUG REACTIONS AT A TERTIARY CARE TEACHING HOSPITAL IN MEWAT REGION OF NORTHERN INDIA
Introduction: Adverse drug reactions (ADRs) poses an unforeseeable menace associated with all the prescribed medicines. Thus, ADRs are monitored and assessed on a large scale in our country by the Pharmacovigilance Programme of India through adverse drug reaction monitoring centres (AMCs). Objectives: This study was done to assess the pattern of ADRs reported in a tertiary care teaching hospital i...
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HOMOEOPATHIC MANAGEMENT OF DECUBITUS ULCER: A CASE REPORT
Decubitus ulcers continue to be a common health problem, particularly among the physically limited or bedridden. Decubitus ulcers may develop into chronic conditions for no apparent reason, persist for prolonged periods, or even last the patient's entire life. Modern medicine mainly serves in managing ulcer wounds through superficial wound cleaning and dressing. But it takes time for healing of de...
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EFFICACY OF PSORINUM IN CHRONIC URTICARIA: A CASE REPORT
Chronic urticaria is a popular skin complaint that is characterized by wheals of various sizes surrounded by erythema and associated with itching and burning as a consequence of Type1 hypersensitivity reaction mediated by IgE antibodies to specific allergen. Most of the population (>20%) have urticaria once somewhere in the life. The conventional management of this condition is associated with ...
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DRUG UTILIZATION PATTERN AND DISEASE PROGRESSION IN HOSPITALIZED PATIENTS WITH COVID-19
Background: The WHO declared the coronavirus disease 2019 (COVID-19) outbreak as a global pandemic in March 2020. Since, no specific drugs are currently available for its treatment it is important to document the prescription patterns. Objectives: To evaluate the drug prescribing pattern and assess the disease progression in the patients hospitalized with COVID-19 in a tertiary care hospital. Meth...
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IN-SILICO IDENTIFICATION OF NEWER POTENTIAL LEMUR TYROSINE KINASE 3 INHIBITORS FOR THE TREATMENT OF BREAST CANCER
Breast cancer refers to cancer emerging from breast tissue, commonly from the lobules that supply the ducts with milk or from the inner linings of milk ducts. Due to the mutation of DNA or RNA from the normal cells and abnormal genes when inherited, cancer cells are evolved. LMTK3 (lemur tyrosine kinase 3) has emerged as an important player in breast cancer, contributing to the advancement of dise...
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FORMULATION AND EVALUATION OF POLYHERBAL IN-SITU GEL FOR GLAUCOMA
Worldwide, glaucoma is the second most important cause of blindness and irreversible vision loss. Raised IOP (Intraocular Pressure) is not always a mark of glaucoma; it is a key risk factor and a cause of glaucomatous optic neuropathy. Herbal preparations have various active and inactive compounds which are not standardized likewise, Camellia sinensis and Areca catechu having various active consti...
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COMPARATIVE STUDY OF ANTI-AGGREGATION PROPERTY OF LEAF PROTEINS OF BRAHMI, FENUGREEK AND TRIDAX ON THE FORMATION OF LYSOZYME AMYLOID FIBRILS
Lysozyme amyloid formation is studied as model in-vitro system to find out natural or synthetic inhibitors of amyloidosis. Protein aggregation and amyloid formation is the basic reason for many neurodegenerative diseases. Indigenous medicinal plants are great source of therapeutic molecules and drugs. Ethnobotanical studies have indicated many plants have neuroprotective functions. We have studied...
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PHYTOCONSTITUENT ANALYSIS AND IN-VITRO ANTI-INFLAMMATORY ACTIVITIES OF PLANTS SOURCES
Bioactive compounds are secondary plant metabolites and are found in small amounts in plants, fruit, vegetables, and edible oils; they have health benefits and provide us an alternative search for drugs or medicines and followed by the minimum side effects. There are various bioactive assays for measuring the functional activities of bioactive compounds, such as phytochemical assays and anti-infla...
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IN-VITRO PHOTOPROTECTIVE EFFECT OF AN ACTINOMYCETE DERIVED MELANIN AGAINST MELANOMA
Actinomycetes are biotechnologically important microorganism as they produce many secondary metabolites and natural pigments, including a dark-brown pigment melanin. Melanin is produced in melanocytes that provides pigmentation to skin. Although many roles have been attributed to melanic pigments, the main role in nature seems to be photoprotection damage. Melanin possesses anti- UV radiation prop...
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FORMULATION AND EVALUATION OF CURCUMIN-LOADED CHITOSAN NANOPARTICLES AND ITS INTRANASAL EFFICACY FOR CNS DELIVERY
Hydrophobic medications that are taken orally having poor bioavailability due to permeability issues. They experience a chemical and enzymatic breakdown in the digestive system and exhibit a significant amount of hepatic first-pass metabolism. Similar obstacles prevent the development of effective therapeutic molecule delivery systems and the discovery of new drugs. It has been revealing that curc...
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FORMULATION AND EVALUATION OF VALSARTAN NANO-EMULSION FOR ITS TRANSDERMAL EFFICACY
Valsartan is a selective angiotensin type I receptor agonist that has been used in the treatment of hypertension disease. The development of a thermodynamically stable and infinitely dilutable nanoemulsion (O/W) of valsartan with surfactant at a low concentration that can enhance its solubility and stability came about as a result of our investigation into the effectiveness of nanoemulsion as a ca...
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QUALITY ANALYSIS OF MARKET SAMPLES OF ŌRILA COLLECTED FROM DIFFERENT MARKETS OF KERALA USING PHARMACOGNOSTIC TOOLS
Ōrila is a well-known drug used in many Ayurvedic recipes in kerala. In most texts Ōrilais seen paired with Mūvilaand together they fare as components of the Daśamula. From very old Kerala commentaries of ancient Ayurvedic texts, Ōrila and Mūvila are seen as Malayalam translations of Pṛśniparṇī and Śālaparṇī respectively. In Kerala Pṛśniparṇīis often identified as Ōrila and...
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EVALUATION OF IN-VITRO ANTHELMENTIC ACTIVITY OF BETA VULGARIS
Plant products are of increasing interest in the search for new drugs and medicines in the treatment of diseases; and the discovery of new alternatives to existing commercially available drugs is an important area of this research due to pathogen resistance. The present investigation focused on the screening of anthelmintic potential of pet-ether, benzene, ethanol and aqueous extracts of the plant...
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EVALUATION OF THE EFFECTIVENESS OF THE EFFECT OF ACETYLCYSTEINE ON INTRARENAL HEMODYNAMICS IN PATIENTS WITH CORONAVIRUS ASSOCIATED NEPHROPATHY
This article discusses the assessment of kidney function in patients with coronavirus-associated nephropathy through Doppler ultrasound of renal vessels. The study focuses on research groups comprising individuals affected by this nephropathy. Dopplerography studies aim to evaluate the effectiveness of N-acetylcysteine in treating coronavirus-associated nephropathy. Doppler ultrasound helps assess...
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EFFECTIVENESS OF INJECTION TERIPARATIDE IN OSTEOPOROTIC INTERTROCHANTERIC FRACTURE TREATED WITH PROXIMAL FEMUR NAILING
Introduction: Osteoporosis is relatively a serious medical condition causing geriatric trauma, which leads to an increase in morbidity and mortality. Early fracture union is important for early mobilization and for good functional outcome. Recombinant parathyroid hormone has shown to accelerate the fracture union and improve the functional outcome. Therefore, in this study we have decided to evalu...
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ANTIDIABETIC POTENTIAL OF PROTEIN AND FIBER RICH MILLET BASED SNACK BAR
Diabetes mellitus has become a global concern with 422 million people affected due to this disease. As the oral hypoglycaemic drugs available in the market have their own set of side effects which can be one of the primary factors towards non-adherence of these medicines among patients, we must explore some natural alternatives in order to deal with this disease in an efficient manner. In such sce...
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DEVELOPMENT OF VALIDATED HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF FERULIC ACID AND ELLAGIC ACID
A simple, precise, accurate and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of ellagic acid and ferulic acid in herbal formulation. Quantification was carried out with pre-coated silica gel aluminium plate G60F254 (10x10cm) as stationary phase, mobile phase consisting of Ethyl acetate: toluene: formic acid: methanol (3.5:...
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SCREENING OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITY OF GLORIOSA SUPERBA IN RODENTS
Background: Traditionally Gloriosa superba is being used as a medicinal plant in outskirts of belagavi, we evaluated and compared the analgesic and anti-inflammatory activities of hydroalcoholic extract of dried aerial parts (rhizomes) of G. superba with standard drugs. Methods: This experimental animal study was carried out in the Research Laboratory, Department of Pharmacology, BIMS, Belagavi. P...
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HPTLC METHOD DEVELOPMENT AND VALIDATION FOR HYDROXYCHAVICOL ISOLATED FROM PIPER BETEL LEAVES
A simple, precise, accurate, and rapid high performance thin layer chromatographic method has been developed and completely validated for the estimation of hydroxychavicol isolated from piper betel leaves powder. The isolation of hydroxychavicol was carried out using flash chromatography. Validation was carried out with pre-coated silica gel aluminum plate G 60 F254 (10 x 10 cm) as the stationary ...
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PHYTOCHEMICAL & PHYSIOCHEMICAL SCREENING OF THE HERBAL DRUG ALOEVERA AND CLITORIA TERNATEA LEAVES EXTRACT
Egyptians referred to aloe vera, a botanical remedy, as "the plant of immortality." It helps with diabetes, hypertension, wound healing, and other medical conditions. Aloe vera gel extract and Clitoria ternatea watery, methanolic, and ethanolic extracts of plants was studied. A small sample of Aloe vera and Clitoria ternatea's ethanolic, methanolic, and watery extracts were put through a phytochem...
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ASSESSMENT OF KNOWLEDGE, ATTITUDE AND PRACTICES OF ADVERSE DRUG REACTION REPORTING AMONG NURSING STAFF OF TERTIARY CARE TEACHING HOSPITAL IN WESTERN RURAL INDIA
Introduction: Underreporting of adverse drug reactions (ADRs) in Pharmacovigilance programme of India (PvPI) may be due to lack of adequate knowledge, attitude and practice among healthcare professionals towards ADR reporting. Aim & Objective: Present study was planned to assess the knowledge, attitude and practices of ADR reporting amongst nursing staff of tertiary teaching hospital in Wester...
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FORMULATION AND EVALUATION OF SUSTINED RELEASE MATRIX TABLET OF METRONIDAZOLE
In this study matrix tablets of metronidazole were prepared by direct compression method which is now days considered a cost effective and simple method of manufacturing. It is considered as an appropriate method for hygroscopic and thermolabile substances. Six formulations of different polymer percentages were formulated (F1-F9). The mean hardness values were measured for all the formulation usin...
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METHOD DEVELOPMENT AND VALIDATION USING HPLC-ESI-MS/MS FOR DETERMINING STABILITY OF TALAZOPARIB IN BIOLOGICAL MATRICES
A highly sensitive, simple, accurate and precise HPLC-ESI-MS/MS method was developed and validated for the quantitative determination of talazoparib in biological matrices. The present study describes the determination of Talazoparib using validated protein precipitation method from human plasma employing Talazoparib 13C D4 as internal standard by electron spray ionization technique. Combination o...
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ANTIPYRETIC ACTIVITY STUDY OF SARCOSTEMMA ACIDUM VOIGT
Sarcostemma acidum Voigt is a xerophytic plant of the family Apocynaceae. Plant is locally known as Somlata. It is a traditional medicinal plant used to prepare Somras. The plant is mainly found in Bihar, West Bengal, Odisha and South India. It is mostly grown in dry rocky places. S. acidum is a shrub, more branched but no leaves. The stems are jointed with each other. These are green, cylindrical...
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