Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIP STUDIES OF SULFADIAZINE- SALICYLALDEHYDE SCHIFF BASE AS AN ANTI-MYCOBACTERIAL AGENTS
Quantitative structure activity relationship is among the most widely used computational technology for analogue-based drug design. A molecular modelling approach using sulfadiazine- salicylaldehyde Schiff base analogue as anti-mycobacterial activity from recently reported literature were taken and was designed using MOE 2009.10. Sulfanilamide sulfa drugs have been shown to inhibit dihydropteroate...
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IMPAIRMENT OF OVARIAN BIOCHEMICAL CONTENTS AND ENZYMES ACTIVITIES DURING POTASSIUM BROMATE (KBRO3-) INTOXICATION IN ALBINO MICE MUS MUSCULUS
Potassium bromate (KBrO3-) is a chemical compound commonly used as a oxidizing agent that has been used as a food additive for baking of white bread, bun, pav and pizza bread. Potassium bromate (KBrO3-) is mainly known to generate free radicals, which cause oxidative damage to essential cellular macro molecules, leading to cause nephrotoxicity in experimental animals. In this part of experiment bi...
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SYNTHESIS AND QSAR STUDY OF NOVEL THIAZOLE MOIETIES HAVING ANTIOXIDANT ACTIVITY
Thiazoles derivatives are an important class of heterocyclic compounds, reported to possess a wide spectrum of biological activities. Moreover, thiazole nucleus occupies a very important place in the field of antioxidant agents. The above observations prompted us to synthesize some novel thiazole derivatives with various substitutions at along with heterocyclic rings in the same framework for syne...
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STUDY OF THE ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF RHIZOMES OF ZINGIBER OFFICINALE IN EXPERIMENTAL ANIMALS
Objective: To evaluate the anticonvulsant property of Zingiber officinale as well as its interaction with conventional anticonvulsant drug using Maximal electroshock seizures (MES) model and to evaluate possible mechanism involved in its action. Method: The present study was done after getting ethical clearance. The rhizomes of ginger were authenticated and extraction of dried rhizomes was done by...
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VALIDATION FOR QUANTITATIVE DETERMINATION OF AZTREONAM IN SIMULATED LUNG FLUID BY UV SPECTROSCOPY METHOD
Aztreonam, a synthetic beta-lactam antibiotic is widely used for the treatment of infections in lungs, meninges, bladder, etc. Its potential use in the treatment of pneumonia and cystic fibrosis has been established. Recently FDA has approved Cayston® for inhalation therapy of Aztreonam in lungs infection. Many studies have been reported on the quantitative determination of Aztreonam by UV spectr...
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EFFECTS OF PORPHYRA VIETNAMENSIS EXTRACT ON TNBS-INDUCED COLITIS IN RATS
Objective: This study aimed to investigate the intestinal anti-inflammatory activity of a methanolic extract of Porphyra vietnamensis in the TNBS model of intestinal inflammation in rats. Methods: The study included (i) Identification and quantification of Porphyra-334 in P. vietnamensis, (ii) investigation of the effect of methanolic extract on DNA cleavage induced by H2O2 UV-photolysis, (iii) 50...
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STABILITY INDICATING RP-HPLC METHOD FOR COMBINATION OF AMBROXOL HYDROCHLORIDE AND LEVOFLOXACIN HEMIHYDRATE IN PHARMACEUTICAL FORMULATION
Ambroxol hydrochloride (AMB) and Levofloxacin hemihydrate (LVF) in combination were separated using Reverse-Phase - High-Performance Liquid Chromatographic (RP-HPLC) method. Mobile phase acetonitrile and 0.05 M potassium di-hydrogen orthophosphate buffer (pH 7.0 adjusted with sodium hydroxide solution) (50: 50, v/v) was selected for this chromatographic method. The separation was achieved in Zorba...
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RISK ASSESSMENT OF SOME HERBAL POWDERS AND HERBAL FORMULATIONS CONTAMINATED WITH HEAVY METALS
Ten herbal medicines, Four herb choornam (Trikatu, Hingwashtak, Triphala and sitopladi) and five herbal compounds - Kutajghan Vati, Gandhak Rasayan, Sarivadi Vati, Chanderprabha Vati, Shankh Vati were tested for levels of heavy metals (Lead, copper, cadmium, iron, chromium, manganese, nickel and zinc). Both herbal extracts and herbal formulations showed the presence of heavy metals. Concentrations...
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COMPARATIVE MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPONENT FROM LAUNAEA PROCUMBENS (ROXB.) AGAINST TYROSINE-PROTEIN KINASE FYN
Plants have been studied since ages for their therapeutic uses. In the earlier time, not much was known about the phytocompounds, but today the constituents of the different plants have been extracted and isolated for the use in the name of medicines or drugs. Flavonoid is one of the most characteristic classes’ of compounds in higher plants known to play several important roles including therap...
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HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF DRUG RELEASE OF LEDIPASVIR AND SOFOSBUVIR IN LEDIPASVIR AND SOFOSBUVIR TABLETS
Analytical scientists of the pharmaceutical industry aimed at developing robust HPLC methods for analysis of generic drug products. This paper deals with HPLC method of analysis for estimation of % drug release of Ledipasvir and Sofosbuvir in Ledipasvir and Sofosbuvir tablets used for the treatment of chronic hepatitis C virus (HCV) infection. For analysis of dual combination drug product, HPLC me...
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