Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
CYTOPROTECTIVE EFFECTS OF MORINDA CITRIFOLIA (NONI) ON CULTURED LENS EPITHELIAL CELLS
Oxidative stress is one of the factor that initiating development of cataract and describes the events leading to lens opacification, generally cataract is a clouding of the lens of the eye that will affect the vision either partially or completely. Proteins that are present in the lens begin to break down and the lens becomes cloudy. This will be avoided by taking external food supplements that a...
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ANTIDIARRHEAL EFFECT OF STEM BARK OF CEIBA PENTANDRA GAERTN (BOMBA-CACEAE) IN RATS
This work aimed to evaluate the antidiarrheal effect of aqueous extract of steam barks of C. pentandra. Diarrhoea was induced by intragastric administration of castor oil. Intestinal transit was evaluated by using the charcoal method. The effect of the aqueous extract on muscarinics and α-adrenergic receptors was evaluated in atropine and yohimbine presence by using charcoal method. The results o...
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EFFECT OF POLYMER RATIO AND EXCIPIENTS ON METOPROLOL TARTRATE RELEASE FROM CHITOSAN – SODIUM ALGINATE POLYMERIC IMPLANTS
Natural biodegradable chitosan-sodium alginate polymer combination is a promising candidate for preparing drug-loaded implants because of the availability and inexpensiveness of the polymers over the semi synthetic biodegradable ones. The main objective of this research was to prepare and evaluate a biodegradable implantable system of the drug metoprolol tartrate because it plays an important role...
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IN-VITRO BIOLOGICAL ACTIVITIES OF FRACTIONS OF ETHYL ACETATE FRACTION OF THE WATER EXTRACT OF ARTOCARPUS HETEROPHYLLUS SENESCENT LEAVES
Artocarpus heterophyllus belongs to the family Moraceae. In Sri Lankan traditional medicine the water extract of A. heterophyllus senescent leaves is used to control diabetes mellitus. The hypoglycemic activity of ethyl acetate fraction of water extract of senescent leaves has been reported. Ethyl acetate fraction (EA/W) was fractionated using sephadex LH-20 column chromatography using the solvent...
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METHOD DEVELOPMENT AND VALIDATION OF CEFEPIME BY USING RP-HPLC ALONG WITH ITS POTENCY
Cefepime is a broad - spectrum new parenteral cephalosporin used to treat moderate to severe nosocomial pneumonia, empirical treatment of febrile neutropenia and infections of the skin and urinary tract. In this present study a simple, accurate and precise reverse phase high performance liquid chromatographic method was developed and validated for analysis of cefepime powder for injectable solu...
5199
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CITRAL ATTENUATES N-NITROSODIETHYLAMINE INDUCED LIVER CARCINOGENESIS IN EXPERIMENTAL WISTAR RATS
Antioxidants are one of the key troupes in tumorigenesis, several natural and artificial antioxidants were shown to have anticancer effects. The aim of the current study is to reveal the chemopreventive nature of citral during diethylnitrosamine (DEN) -induced liver cancer in male Wistar albino rats. Administration of DEN to rats caused in amplified relative liver weight and serum marker enzymes a...
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METHOD DEVELOPMENT AND VALIDATION FOR THE ESTIMATION OF AMBROXOL HCl IN PHARMACEUTICAL DOSAGE FORM
Rapid, sensitive, specific and validated colorimetric methods have been developed for the quantitative estimation of ambroxol HCl in bulk and dosage form. The current method was developed based on oxidation of ambroxol with Gibb’s reagent (method I) and p-diethyl amino benzaldehyde in toluene (method II). The formed intense colour complex was measured at 537.2 nm and 438.4 nm respectively. Under...
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SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF MORPHOLINE MANNICH BASE DERIVATIVES
In the present study 10 morpholine mannich base derivatives were synthesized by three component reaction of morpholine, N-phenylacetamide and various substituted benzaldehydes. Progress of the reaction was monitored by thin layer chromatography and the compounds synthesized were characterized by ATR and 1HNMR techniques. Antimicrobial activity of the synthesized compounds was evaluated against gra...
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DIETHYLSTILBESTROL (DES) INDUCED ENDOMETRIOSIS IN BALB/C MICE TREATED WITH MMP-2 AND 9 INHIBITORS-I
Diethylstilbestrol (DES) is an endocrine disturbing compound it can mimic and perform like a natural hormone, which mimics estradiol by binding to the estrogen receptor. This compound mainly reproductive target, so in this study used to induce endometriosis. Endometriosis is an estrone dependent constant gynaecological disorder. Here it, intends to induce endometriosis and treated by the MMP inhib...
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DEVELOPMENT AND CHARACTERIZATION OF BILAYER TABLET CONTAINING TRAMADOL AND PREGABALIN AS A GASTRIC BUOYANT DRUG DELIVERY SYSTEM FOR COMBINATION PHARMACOTHERAPY OF NEUROPATHIC PAIN
Experiments were performed to design, develop and characterize bilayer buoyant tablets with Tramadol (TH), immediate release layer and Pregabalin (PGB), sustained release layer. Super disintegrants like crosscarmellose sodium and sodium starch glycolate, for IR layer where as Hydroxypropyl methylcellulose (HPMC-K4M, HPMC-K100M) and sodium carboxymethyl cellulose, as sustaining polymers for SR laye...
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