Most Cited
| Year | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | Total |
|---|---|---|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 549 | 628 | 408 | 376 | 3466 |
| Citations | 2186 | 1048 | 351 | 329 | 66 | 6 | 3986 |
| Projected Impact Factor | 6.64 | 4.43 | 2.15 | 1.07 | 0.58 | 0.38 |
THE SYNTHESIS OF QUINAZOLON-1,3,4-OXADIAZOLE ANALOGUES AND STUDIES OF THEIR ANTIMICROBIAL AND ANTIOXIDANT ACTIVITY
A series of conjugation of two heterocycles 1, 3, 4-oxadiazole and quinazolone were synthesized and screened for antimicrobial as well as antioxidant activity. Compound4-(4-oxo-2-phenyl-quinazoline-3(4H)-yl)-benzohydrazide 3 on cyclization with different aromatic acids in the presence of phosphoryl chloride (POCl3) give different 1, 3, 4-oxadiazole derivatives. Similarly, compound 3 on reaction wi...
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DESIGN AND DEVELOPMENT OF DANTROLENE SPHERICAL AGGLOMERATES FOR IMPROVEMENT IN BIOAVAILABILITY
The purpose of this research was to obtain directly compressible agglomerates of Dantrolene using spherical agglomerates. Spherical agglomeration technique enables simultaneous crystallization and agglomeration. Sodium hydroxide acted as a good solvent, aqueous solution of PEG 6000 in hydrochloric acid served as bad solvent and isopropyl acetate was used as bridging liquid. The optimization of for...
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1742
ESTIMATION OF PROTEINS IN PLANTS OF FORENSIC SIGNIFICANCE (RICINUS COMMUNIS AND CANNABIS SATIVA) BY UV-SPECTROPHOTOMETRY AND GEL ELECTROPHORESIS METHOD
Proteins play a significant role in living beings. In animals, where proteins are involved in the body built, the formation of tissues, organs, etc., in plants, proteins regulate the respiration, photosynthesis, growth, and reproduction. There are some proteins which are specific to the plant or a particular species of plant. Proteomics is a multidisciplinary branch of science that deals with the ...
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PREDIABETES: APPROACH AND MANAGEMENT
About 5-10% of individuals with the condition of prediabetes or intermediate hyperglycemia develop diabetes annually. Prediabetes can revert to normal glycaemic state as well. Reversion to normal glucose, even when transient, is associated with a significant 56% reduced risk of future diabetes independent of previous treatment. Prediabetes is associated with many microvascular as well as macro-vas...
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1686
SUGGESTED VENOUS THROMBOEMBOLISM (VTE) RISK STRATIFICATION SHEET FOR ORTHOPEDIC SURGERIES
Background: Major orthopedic surgeries are divided into 3 major surgeries: total or partial hip replacement (TPHR), total knee replacement (TKR), and hip fracture surgeries (HFS), these surgeries are considered as high-risk surgeries for the development of venous thromboembolism (VTE) which includes deep vein thrombosis (DVT) and pulmonary embolism (PE). In general there are several factors that i...
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TOTAL PHENOLS CONTENT, FLAVONOID CONCENTRATION AND ANTIOXIDANT ACTIVITIES OF LEAVES EXTRACTS OF VITEX AGNUS-CASTUS L. GROWING WILD IN MOROCCO
Vitex agnus-castus L. (Verbenaceae) commonly known as Chaste tree, is a shrub widely distributed in the Middle East and Southern Europe. Traditionally used for the treatment of several health problems and symptoms, such as premenstrual ones and spasmodic dysmenorrhea, certain menopausal conditions, insufficient lactation, and acne. Several reports have indicated that Vitex agnus-castus contained f...
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1824
EFFICACY AND COMPLICATIONS OF PROLONG LINEZOLID THERAPY IN METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) INFECTED SUBCUTANEOUS ABSCESS MODEL IN WISTAR RAT
Linezolid has a better choice for the eradication of both community and hospital acquired methicillin-resistant Staphylococcus aureus (MRSA) infections, but its use is limited because of its complications. The study elucidated the efficacy and complications of prolonged therapy of linezolid in MRSA infected rats. The rats were rendered neutropenic by an intraperitoneal injection of cyclophosphamid...
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MOLECULAR DOCKING, PHARMACOPHORE MODELLING AND 3D QSAR ANALYSIS OF NOVEL CHALCONE DERIVATIVES
Chalcone based structures have many interesting biological properties like anti-malarial, anticancer, antiviral, antibacterial, antifungal, anti-hyperglycaemic and photo-cytotoxicity activities. In this study, the novel chalcone derivatives (1a-1l) have been synthesized and investigated for antimicrobial activities. The MIC results of antimicrobial activities reveal that one of the chalcone deriva...
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METHYLATION EFFECT OF APIGENIN 8-C-GLUCOSIDE TOWARDS ANTIOXIDANT POTENTIAL – A DFT STUDY
The extensive study on O - methylated flavonoids reveals that substitution with methyl group enhances the radical scavenging behavior in certain compounds. Due to potential applications of C-glycosides in metabolic engineering, methylation in these flavonoids needs to be analyzed in both theoretical and experimental levels for their radical scavenging behavior. In this work naturally occurring C- ...
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ANTIOBESITY, ANTIHYPERLIPIDEMIC AND ANTIDIABETIC AGENTS OF PROTO-CATECHUIC ACID IN HIGH FATTY DIET ALONG WITH ALLOXAN INDUCED DIABETES
Aim: The present investigation was carried out by evaluating the effect of protocatechuic acid (PCA) on a high-fat diet (HFD) along with a low dose of alloxan-induced hyperglycemia in male Wistar rats. Methods: In the present study, administration of high fatty diet (HFD) for 45 days along with low dose of alloxan (80 mg/kg) in rats on 30 days produced significant high fatty diet in the, body we...
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