A STUDY COMPARING RESCUE MEDICATIONS: ARFORMOTEROL AND SALBUTAMOL NEBULIZATION IN EXACERBATION OF NON-SEVERE ASTHMA AT A TERTIARY CARE CENTER, NOT NEEDING HOSPITALIZATION
Objectives: Arformoterol is the (R, R) - enantiomer of formoterol, a short and long acting β-2 agonist bronchodilator and is distinguishable from the racemic (R, R/S,S) - diasteriomer of formoterol, which is most commonly used. Some in vitro data show significant bronchodilatation, inhibition of inflammation and marked baseline airway reversibility with arformoterol. Yet, there is a dearth of stu...
Candesartan Cilexitil is an angiotensin II receptor antagonist used mainly for the treatment of hypertension. Candesartan cilexitil is a BCS class II drug having low solubility and high permeability. Candesartan Cilexitil is a prodrug which is rapidly converted to the active drug, Candesartan, by ester hydrolysis during absorption from the gastrointestinal tract. The bioavailability of Candesartan...
Identification of protein-ligand interactionnetworks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics. In this study we have developed a novel computational strategy to identify ligand binding profiles of proteins across gene families and applied it to predi...