Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
COLON DRUG DELIVERY SYSTEM, ADVANCE DEVELOPMENT AND EVALUATION: A REVIEW
Colon targeted drug delivery system is a significant part of the pharmaceutical dosage form. Because the colon targeted formulation system only responds to the colon-specific physiological conditions, a triggering mechanism is required. Site of colon provides local and systemic drug delivery. Inflammatory bowel disease can be treated by localized delivery of drugs. The systemic side effect can be ...
3205
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IN-VITRO MUTAGENIC, GENOTOXIC AND ANEUGENIC POTENTIAL OF OMEPRAZOLE
The aim of this investigation was to re-evaluate the in-vitro mutagenic, genotoxic, and aneugenic potential of omeprazole through the Ames test, comet (SCGE), and cytokinesis-block micronucleus assays (CBMN), as previous reports on the mutagenic and genotoxic effects of omeprazole are scarce and inconclusive. The results of this study indicated a negative mutagenic effect through the Ames test. Co...
1750
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PREPARATION AND EVALUATION OF NON-IONIC SURFACTANT VESICLE USING STATISTICAL OPTIMIZATION: OLMESARTAN USED AS MODEL DRUG
The purpose of the present work was to prepare and evaluate olmesartan-loaded non-ionic surfactant vesicles (niosomes) to get sustained release by increasing the solubility and bioavailability. Ether injection and thin-film hydration methods were used for the preparation of all formulations as per the factorial design to study the effect of the three independent variables X1 (amounts of span 60), ...
1211
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EVALUATION OF THE SERUM LEVELS OF SOME TRACE ELEMENTS AND ANTIOXIDANT LEVELS IN APPARENTLY HEALTHY INDIVIDUALS WITH FAMILY HISTORY OF TYPE 2 DIABETES IN NNEWI, NIGERIA
There is a paucity of data on studies evaluating trace elements and antioxidant levels and susceptibility of offspring of diabetic parents to type 2 diabetes in Nigerian population. This study evaluated the serum level of some trace elements and antioxidants among apparently healthy individuals with a family history of type2 diabetes mellitus (FH-T2DM). This was a cross-sectional study involving 1...
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GENOMIC STRUCTURAL IDENTIFICATION AND IMMUNOINFORMATICS STUDIES FOR SARS‐COV‐2
Coronaviruses are a group of viruses that belongs to the Coronaviridae family. These viruses have helical symmetry, enveloped, positive-sense, single-stranded RNA genome with nucleocapsid that causes diseases in birds and mammals. SARS-CoV 2 complete genome has genome size of 29,903 bp, having nine genes identified as Orf1a Polyprotein, Orf1ab Polyprotein, ORF3a Protein, ORF7a Protein, ORF8 Protei...
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SYNTHESIS AND CHARACTERIZATION OF 6 – HYDROXY – 3, 4 -DIHYDROQUINOLINONE CILOSTAZOL IMPURITY-A AS PER INDIAN PHARMACOPOEIA
Impurity profile study is critical for getting market approval of finished dosage forms from regulatory authorities. There are many manufacturing firms (small and medium scale) in India that they cannot afford the high priced USP reference standards for analysis. So, the availability of cheaper affordable IP reference standards will help them adhere to quality guidelines for active pharmaceutical ...
1449
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FORMULATION AND CHARACTERIZATION OF CLOZAPINE ADHESIVE PATCHES USING VARIOUS PRESSURE SENSITIVE ADHESIVES AND PERMEATION ENHANCERS
The present research work was intended to develop and characterize the transdermal adhesive patch of clozapine using different types of acrylate, polyisobutylene and silicon adhesives. Various permeation enhancers such as 1, 8 – cineole, D-limonene, Azone, IPM and Oleic acid were also evaluated to achieve desired permeation rate and hence to attain the improved bioavailability as compared to ora...
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ANALYSIS OF BIOLOGICALLY ACTIVE COMPOUNDS IN JIMSON WEED LEAFS
Jimson weed (Datura stramonium) members of the Solanaceae plant family; serve as major folklore medicinal herbs. The biologically active compounds spectrum in leaves of Datura stramonium L. was investigated by GC-MS with NMR & FTIR analysis. Steroids, terpenoids, anticholinergic alkaloids, atropine, and scopolamine, are detected. Twenty of them are new constitutions for the species, and eight ...
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DEVELOPMENT, OPTIMIZATION AND IN-VITRO CHARACTERIZATION OF GLICLAZIDE NANOSPONGE TABLETS FOR ORAL ADMINISTRATION
Poor bioavailability by the oral route is noticeable with the majority of new active pharmaceutical ingredients due to its dissolution rate-limited absorption. Gliclazide is an oral anti-hyperglycemic drug, though it is a class II drug, results in poor oral bioavailability. The present investigation was undertaken to prepare polymeric nanosponges of an oral anti-hyperglycemic drug Gliclazide to ac...
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GC-MS ANALYSIS AND IN-VITRO CYTOTOXICITY STUDY OF DENDROPHTHOE FALCATA AND TRIDAX PROCUMBENS EXTRACTS AGAINST HACAT CELLS LINE
The present study shows the cytotoxic effect of Dendrophthoe falcata (L. f) and Tridax procumbens Linn. extracts against HaCat (Skin cancer) cell line by MTT and SRB assay method. The phytochemical screening of extracts dichloromethane: methanol (DM), methanol: water (MW), and ethanol: water (EW) revealed the presence of secondary metabolites such as alkaloids, flavonoids, saponins, tannins, stero...
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