Human pharmaceuticals and their metabolites affect the endocrine system and physiology of aquatic wildlife, which is an important global ecological concern. The published data from open-source toxicology and worldwide web resources reveal about 175 pharmaceuticals that can affect estrogen pathways to disrupt the endocrine system and metabolism. Such studies demand additional investigations on fish...
In recent years, the nasal route is gaining increasing importance for systemic administration of drugs and targeting to brain. The drug delivery to the brain is limited due to several factors, including presence of blood-brain barrier, enzymatic degradation, and efflux of drug by P-glycoprotein. Nasal route is employed to target the brain using various direct pathways via nasal mucosa and to bypas...
GREEN SYNTHESIZED GOLD NANOPARTICLE: A NOVEL APPROACH TOWARDS BIOMEDICAL AND PHARMACEUTICAL APPLICATIONS
Green synthesized gold nanoparticle is one of the most promising drug delivery approaches with biocompatibility and biodiversity. Various plant sources such as Aegle marmelos, Eugenia jambolana, Soursop, Persea Americana, Terminalia chebula, Aloe arborescens, Musa paradisiacal, Alternanthera philoxeroides, Cissus quadrangularis, Sterculia acuminate, Garciniaindica choissy, Eucalyptus globulus, Ros...
In recent years, natural products such as Boswellic acids (BAs) have attracted researchers around the globe because of their significant potential against various diseases without any toxic effects. Boswellic acids, which belong to the pentacyclic triterpenes type of class, are extracted from the gum-resin portion of Boswellia serrata and many other different species such as Boswellia sacra, Boswe...
A COMPLETE RECAPITULATION OF A DRUG DELIVERY BASED ON OSMOTIC PRESSURE: AN OSMOTIC DRUG DELIVERY SYSTEM
Conventional dosage forms are the systems that don't have complete control on their drug release, and also there is no control over the effective concentration at the target site. So in order to overcome this problem the osmotic drug delivery system was developed for the controlled delivery of drugs. This osmotic drug delivery system includes dosage forms for oral administration and implantable sy...
Solid dispersion extended-release system involves amorphization of drug material that leads to creating an alternative pathway for poorly water-soluble drugs. The drug increases solubility due to an increase in apparent solubility of the particular drug. Crystalline lattices of the drug are disturbed during its manufacture, which minimizes the crystal packing energy for solubilization. Along with ...
Heterocyclic compounds represent the important structural key in pharmaceutical medicinal chemistry. In literature, five-membered heterocycles are reported to be a core moiety of various pharmaceutical drugs. Oxadiazole or furadiazole is a five-membered heterocyclic nucleus and is considered to be derived from furan by replacement of two methane (-CH=) groups by pyridine type nitrogen. Oxadiazole ...
Covid-2019: The pandemic that shook the entire world. There is no sarcasm if one says there will be a Pre and Post- COVID-19 world. Worldwide, millions of cases have been identified, and heaps have died. So many nations worldwide have issued a lockdown to stop the coronavirus's unfolding, which triggered giant financial fallout. Like each and every incident has two dimensions, Covid-19 possesses b...
ANTIBACTERIAL ACTIVITY, PHARMACOKINETICS AND MOLECULAR DOCKING OF PHYTOCHEMICALS FROM RICINUS COMMUNIS` LEAF EXTRACT
To evaluate the antibacterial activity, pharmacokinetics and molecular interaction of the compounds from Ricinus communis` leaf extract. Antibacterial activity was assessed by using the micro-dilution method. The chemical constituents of the methanolic leaf extract were assessed by using gas chromatography-mass spectrophotometry (GC-MS). The drug-like and toxicity properties of the phytocompounds ...
BIOLOGICAL PROPERTIES OF EXTRACTS FROM LOCALLY GROWN BANANA LEAVES INDICATE THEIR POSSIBLE USE FOR WOUND DRESSING IN ARUSHA, TANZANIA
This study assessed the biological properties and safety profile of extracts from locally grown banana leaves in Arusha (Tanzania), to affirm their possible use for wound dressing. Screening for phytoconstituents in extracts from studied banana plant species, ijuhi inkundu (IJ) mlelembo (ML) and kimalindi (KIM), revealed the presence of various secondary metabolites; anthraquinones, alkaloids, fla...