Most Cited
| Year | 2020 | 2021 | 2022 | Total |
|---|---|---|---|---|
| No. of Published Articles | 745 | 760 | 548 | 2053 |
| Citations | 699 | 263 | 21 | 983 |
| Projected Impact Factor | 3.76 | 2 | 0.64 |
APPRAISEMENT OF DRUG UTILIZATION PATTERN OF ANTIMICROBIALS IN THE GENERAL MEDICINE DEPARTMENT OF A TERTIARY CARE TEACHING HOSPITAL – A PROSPECTIVE OBSERVATIONAL ANALYTICAL STUDY
AIM: To see the appraisement of drug utilization pattern of antimicrobials in the general medicine department of a tertiary care teaching hospital. Methodology: A prospective observational, analytical study was done on patients admitted in general medicine of Maharaja Institute of Medical Sciences, Vizianagaram, Andhra Pradesh, India information regarding age, gender, diagnosis, patients present/p...
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MICROWAVE ASSISTED SYNTHESIS AND EVALUATION OF ANTICONVULSANT ACTIVITY OF SOME 1, 4-DIHYDROPYRIDINE DERIVATIVES
In the view of an extensive literature survey that revealed the anticonvulsant profile of 1,4-dihydropyridines and 1,3,4-Thiadiazole, we have coupled these two moieties with the aim of achieving an enhanced anticonvulsant effect. In present investigation some of ethyl-1-((5-amino-1, 3, 4-thiadiazol-2-yl) methyl)-5-ethyl-2, 6-dimethyl-4-substituted phenyl-1, 4-dihydro-pyridine-3-carboxylate derivat...
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FORMULATION AND EVALUATION OF MUCOADHESIVE VAGINAL TABLET FOR THE TREATMENT OF BACTERIAL VAGINOSIS
The primary purpose of this study was to formulate a mucoadhesive vaginal tablet of clindamycin phosphate. It developed to achieve an excellent therapeutic effect and patient compliance in the treatment of bacterial vaginosis. The formulation has a sustained-release effect with good mucoadhesion due to mucoadhesive polymers like Polycarbophil and Carbopol 971P NF, which decreases dose frequency. T...
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ANTIOXIDANT ACTIVITY OF LEAVES SOLVENT EXTRACT OF MIMUSOPS ELENGI LINN.
The present study was to estimate the total phenolic content, flavonoids content and evaluate the in vitro antioxidant activity of alcoholic and aqueous extract of the leaves of plant Mimusops elengi Linn. Total phenolic content was determined calorimetrically using Folin ciocalteu reagent, and Total flavonoid content was determined by aluminum chloride method. The total phenolic content of methan...
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IN-SILICO SCREENING AND MODELING OF DELETERIOUS nsSNPs IN HUMAN GENE FBN1 FOR MARFAN SYNDROME
Marfan syndrome (MFS) is a common dominant inherited disorder that affects connective tissue, which is associated with mutation of the gene FBN1. The protein encoded by this gene contributes to the final structure of microfibrils. Single nucleotide polymorphisms (SNPs) of this gene links to variations in gene expression phenotypically among patients. Therefore SNPs would be the main target for ide...
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EFFECT OF ALFUZOSIN ON ETHYLENE GLYCOL AND AMMONIUM CHLORIDE INDUCED UROLITHIASIS IN MALE RATS
Urolithiasis is the most prevalent urinary tract disorder in males. Alfuzosin is a selective antagonist of post-synaptic α1a adrenoceptor, causing relaxation of smooth muscle in the bladder and prostate, which results in an improvement of urine flow and prevents ureter stones. The present study was aimed to evaluate the effectiveness of Alfuzosin on rats as a preventive and curative agent against...
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EVALUATION OF PESTICIDE CHLORPYRIFOS TOXICITY ON DROSOPHILA MELANOGASTER
Chlorpyrifos is one of the commonly detected pesticides found in food and water. Extensive use of it in agriculture and its persistence in the environment have raised public concern to overcome the pollution and toxicity problems. Exposure to chlorpyrifos poses several harmful effects to animal and human health. And the pathology in neurodegenerative diseases is mainly because of mitochondrial dys...
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HYPOGLYCEMIC EFFECTS OF LUFFA ACUTANGULA (L.) ROXB. FRUIT EXTRACT IN NORMAL AND STREPTOZOTOCIN-INDUCED DIABETIC RATS
Luffa acutangula (L.) Roxb. (Family: Cucurbitaceae) has been used in the folkloric Indian medicinal system to treat numerous health conditions. The fruits of the plant have been used in dysentery, jaundice, diabetes, hemorrhoids, leprosy, and ringworm infection. The present study aimed to establish the hypoglycemic effect of the aqueous fruit extracts of Luffa acutangula was investigated in normal...
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NEW STABILITY INDICATING UFLC METHOD FOR SIMULTANEOUS ESTIMATION OF METFORMIN HCL AND VILDAGLIPTIN IN BULK AND SOLID DOSAGE FORM
A new stability indicating Ultra-Fast Liquid Chromatography (UFLC) method was validated for the simultaneous estimation of Metformin hydrochloride (MET) and Vildagliptin (VILDA) in bulk and tablet dosage form as per the International Council for Harmonization guidelines. Chromatography developed on Shimatzu UPLC, X-Bridge C18 column equipped with PDA detector. Mobile phase composed of phosphate bu...
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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL QUINAZOLINONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
A series of quinazolinone derivatives were synthesized and screened for anti-inflammatory activity. 5-chloro anthranilic acid undergoes acetylation in the presence of acetic anhydride and anhydrous sodium acetate to give 5-chloro-N-acetyl anthranilic acid as intermediate-I which upon cyclization in the presence of phosphorous pentaoxide, glacial acetic acid, and para aminobenzoic acid to yield 4-[...
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