Posted by admin on Nov 30, 2025 in |
Background: Pemphigus group disorders, presents clinically as flaccid blisters over skin and (or) mucosa and show acantholytic cells on tzanck smear. This condition requires longer duration of treatment, currently systemic steroids, immunosuppressant’s, DCP and biologicals etc are in use. In this study we compare the efficacy and safety of DCP vs rituximab therapy in pemphigus group of disorders. Objectives: To compare the Efficacy and safety of rituximab vs DCP in pemphigus group of disorders. Method: Present study is prospective study included 20 patients of pemphigus group presented to opd of DVL department, clinically presented with flaccid bulla, on tzanck acantholytic cells and Direct immunofluorescence (DIF) proved cases included in study. These patients were divided randomly into two groups. Group A includes 10 patients Receiving DCP pulse, group B includes 10 patients receiving rituximab injection, follow up is done for 24 months. Results: Out of 20 patients, group A with 10 patients receiving rituximab showed better improvement with no recurrence during the follow up period of 24 months, while group...
Read More
Posted by admin on Nov 30, 2025 in |
The objective of this work was to create a polyherbal formulation and evaluate its antibacterial and wound-healing properties in an in-vitro setting. Physicochemical properties of a topical polyherbal formulation were assessed with the chitosan, gelatin, neem, pectin, honey, and aloe vera were combined in different proportions. Polyherbal formulations were assessed for their tensile strength, swelling behavior, moisture retention, microbial penetration, honey release, pH, folding endurance, thickness, water vapor transmission in the prepared formulation. In-vitro activity revealed that F5 formulation had the better wound healing potential as compared to F4 and F3. Thus, we can conclude that enhanced dressings with good wound healing capabilities can lead to new possibilities in the treatment of wound healing related to burns. The outcome of this investigation indicates that the film made with various herbs and 5.4 ml of honey meets all the specifications for wound dressings, including thickness, weight, and folding endurance. The polyherbal formulation has tensile strength of 26N/mm2, moisture uptake of 17.14 ± 1.12 to 26.7 ± 2.17%, and swelling behavior of 85.38. Its antibacterial...
Read More
Posted by admin on Nov 30, 2025 in |
Introduction: Antimicrobial resistance is a burning problem globally due to irrational use of antibiotics. Drug utilization study is a strong tool for evaluating rational use of antibiotics. Objective: To evaluate the drug utilization pattern, to assess the risk factors associated with Neonatal sepsis & to encourage rational prescribing for these patients in tertiary care teaching hospital. Materials and Methods: It was a prospective study in NICU of tertiary care hospital for duration of one year. Case record forms were used to collect the information regarding demographic details, maternal and delivery details, symptoms and co-morbidities in neonates with sepsis, final diagnosis and medications administered. Antimicrobials and other drugs use data such as selection of drug, dosage form and route of administration, duration were collected as per WHO guideline for drug utilization study (core indicators) and were analyzed using SPSS. Results and Discussion: Majority of the patient (42.85%) had low birth weight of less than 2.5 kg. Prematurity is a major cause of low birth weight (less than 2.5kg). 82.5% of patients admitted were...
Read More
Posted by admin on Nov 30, 2025 in |
P-glycoprotein (P-gp) is a membrane efflux transporter influencing drug absorption and disposition. Inhibiting P-gp may increase plasma levels of substrates like digoxin, heightening toxicity risk. This study aimed to classify 35 drugs based on their molecular docking-derived binding affinity to P-gp and their potential to inhibit digoxin transport, using estimated inhibition constants (Ki). Docking simulations were performed using AutoDockVina. Physicochemical parameters were gathered, and binding energies (ΔG) were converted to Ki values. Drugs were ranked using a Ki ratio relative to digoxin (Ki-drug/Ki-dgx). Four drugs (conivaptan, telmisartan, indinavir, and troglitazone) showed stronger affinity than digoxin (Ki < Ki-dgx), indicating high risk of interaction. Diltiazem displayed indirect interaction through aldosterone modulation. The classification revealed 12% strong, 56% moderate, and 32% weak inhibitors. This computational framework allows early screening of P-gp-mediated drug–drug interactions and can guide clinical decisions involving digoxin therapy in polypharmacy...
Read More
Posted by admin on Nov 30, 2025 in |
Mesalamine is a key therapeutic agent used in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease. Ensuring its purity and controlling related impurities is critical for drug safety and efficacy. This study focuses on the development and validation of a robust reversed-phase high-performance liquid chromatography (RP-HPLC) method for the simultaneous detection and quantification of three structurally related impurities Impurity G, Impurity K, and Impurity L in mesalamine pharmaceutical formulations. The chromatographic separation was achieved using an Agilent C18 column with an isocratic mobile phase composed of methanol and 0.1% acetic acid (52:48, v/v), at a flow rate of 0.85 mL/min, with detection at 229 nm. The method was validated in accordance with ICH Q2(R2) guidelines, covering critical parameters such as specificity, linearity (R² ≥ 0.999), precision (%RSD ≤ 0.65), accuracy (% recovery 94.8%–96%), robustness, limit of detection (0.20 µg/mL), and limit of quantification (0.62 µg/mL). The assay demonstrated high reliability for quality control applications and routine analysis of mesalamine products. Additionally, the method showed...
Read More
