Posted by admin on Sep 30, 2026 in |
Background: Non-communicable diseases account for 41 million deaths globally and 5.2 million deaths in India. Siddha interventions for diabetes, asthma, and hypertension have been provided at Government Siddha Medical College and Hospital (GSMCH), Palayamkottai. Evaluation of Quality of Life (QoL) and treatment satisfaction is important to assess patient-centered outcomes of integrative care. Objective: The present study was undertaken to assess the Quality of Life and treatment satisfaction among patients with Diabetes Mellitus (Neerizhivu), Bronchial Asthma (Iraippu Irumal), and Systemic Hypertension (Raththa Pitham) attending Special Siddha OPDs at GSMCH, Palayamkottai. The study also aimed to evaluate domain-wise quality of life scores across selected sociodemographic and clinical characteristics within each disease group and to compare treatment satisfaction domain-wise scores among patients with Diabetes Mellitus, bronchial asthma and Systemic Hypertension. Materials and Methods: A hospital-based cross-sectional study was conducted from August to November 2023 among 90 patients selected by systematic random sampling (30 each with diabetes, asthma, and hypertension) receiving Siddha treatment for at least six months. QoL was assessed using WHOQOL-BREF...
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Posted by admin on Sep 30, 2026 in |
This study’s objective is to formulate and develop a fast mouth dissolving strip which will contains a febuxostat as an API against gout disease. This strip is made by utilizing solvent casting method. To the manufacturing of febuxostat fast mouth dissolving strip, a two-factor (23) factorial design was used. The independent factors for the fast mouth dissolving strip were percentage of HPMC and PEG 400, whereas dependent variables were percentage of cumulative drug release and disintegration time. Febuxostat fast mouth dissolving strip was evaluated through organoleptic properties, thickness, moisture content and moisture uptake, drug content uniformity, weight uniformity, tensile strength, disintegration test, folding endurance, surface pH, swelling index, in-vitro drug release. In-vivo bioavailability study, stability study performed on the optimized batch B6. Disintegration time for optimized batch found that 15 seconds. The strips were white in color and plane in texture. The thickness of optimized batch found that 0.24 mm, the drug content uniformity was 87.99 % of optimized batch which was calculated by dissolving strip for number of...
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Posted by admin on Sep 30, 2026 in |
The study described here is based on an in-silico approach to rank seven thiazolo-imidazoles and similar compounds, selected using Chem-mimic and PubChem similarity indices, for Parkinson’s disease bioactivity, with the receptor target PDB ID 2V5Z. An AI-based approach using DiffDock-L and Alfa Flow NeuroSnap AI was used for docking and dynamic simulation studies. Sprint-AI was used for ranking and bioactivity assessment. The physical disabilities associated with Parkinson’s disease include paucity of movement, muscle stiffness, and tremor at rest. It is a progressive neurodegeneration of the substantia nigra with neuronal loss in the pars compacta. Levodopa was used to treat Parkinson’s disease. This resulted in improved memory, temporary sleeplessness, and a feeling of heaviness. Anticholinergics were used before Levodopa. A monoamine oxidase inhibitor was used to increase dopamine levels. Imidazole scaffolds, with or without a sulfur atom in the ring system, proved useful for PD treatment. Imidazoles possess neuroprotective activity that reduces neuroinflammation associated with PD. They inhibit PDE10A, which is associated with PD neuroinflammation. The sulfur atom helps with...
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Posted by admin on Sep 30, 2026 in |
Background: Expiry of medicines in retail pharmacies wastes money, endangers patients and harms the environment, yet the drivers of this loss remain poorly characterised in Zimbabwe. Aim: This study assessed expiry date management practices and compliance levels among supervisors of registered retail pharmacies in Zimbabwe, identified the operational and regulatory factors contributing to medicine expiry, and determined the categories of medicine most prone to expiry. Methods: A cross-sectional survey was conducted using an online questionnaire incorporating a twenty-one item, five-point Likert scale. The link was disseminated through professional pharmacist groups, yielding a voluntary response (non-probability) sample of 122 supervisors drawn from six of Zimbabwe’s ten provinces. Data were summarised using descriptive statistics in SPSS, with chi-square tests for associations between categorical variables. Results: All respondents (100%) reported using first-expired-first-out or first-in-first-out rotation, 91.0% used inventory software and 100% reported induction training. However, none (0%) had ever notified the Medicines Control Authority of Zimbabwe of expired stock, all (100%) confirmed the absence of a national register for expired products, and...
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Posted by admin on Sep 30, 2026 in |
Calcium carbonate is a pharmacopoeially recognised pharmaceutical agent used in the management of calcium deficiency, hyperphosphataemia, and acid-peptic disorders. Conventional oral solid dosage forms such as tablets are associated with patient compliance challenges, particularly in paediatric and geriatric populations due to swallowing difficulties and poor palatability. Medicated lollipops represent a confectionery-based drug delivery approach that combines therapeutic dosing with improved palatability and patient acceptability. The present study aimed to formulate and evaluate medicated lollipops containing calcium carbonate (500 mg per unit) using a 3² full factorial design, with sucrose (X1) and dextrose (X2) as the two independent variables, each evaluated at three coded levels (-1, 0, +1). A total of nine batches (F1 to F9) were prepared by the heat-fusion moulding method. Each formulation was evaluated for physical appearance, weight variation (mean ± SD, n = 3), hardness (mean ± SD, n = 3), friability (mean ± SD, n = 3), drug content (complexometric titration, mean ± SD, n = 3), in vitro dissolution in 0.1 N HCl (pH...
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