Posted by admin on Oct 31, 2015 in |
The present study was aimed to investigate the antihyperglycemic effect of the Dipteracanthus prostratus nees. And it’s probable mechanism of action in Streptozotocin induced diabetes. Wistar albino rats were used to evaluate the antihyperglycemic effect of toluene (TEDP, 100 mg/kg and 200 mg/kg, body weight) and methanolic (MEDP, 100 mg/kg and 200 mg/kg, body weight) extract of D. prostratus. Changes in body weight and blood glucose level were evaluated at the beginning of the experiment and on day 7, 14, and 21 subsequently. Lipid profile and histopathological examination were also performed. TEDP at 200 mg/kg produced a significant stimulating body weight and reduced blood glucose level in treated diabetic rats from day 7, apart that MEDP also showed similar activity from day 14. Furthermore, significant differences in lipid profiles by TEDP treated rats at 200 mg/kg, as compared to diabetic control and normal rats were also observed. Histopathological studies showed comparable regeneration of islet cells necrosed by Streptozotocin, by both the extracts. In conclusion results revealed that the TEDP...
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Posted by admin on Oct 31, 2015 in |
Patients undergoing Haemodialysis are mostly affected with their physical and mental function. Assessing Health Related Quality Of life is mainly to challenge these conditions in patients and provide a better quality of life. An observational prospective study was conducted in the dialysis ward of a tertiary care hospital for a period of 6 months using KDQOL, consisting of 36 valid items focusing on the physical, mental component summary, burden of kidney disease, symptoms and effects of disease in daily life. A total of 99 patients of all the age and sex groups and patients on Haemodialysis were included. Comparing all the aspects of HRQOL in patients undergoing Haemodialysis, majority (N=59) were illiterate, maximum of patients of age group (40-49) were mostly affected, males being more. The sleep pattern, as observed, a maximum of patients had either lack of sleep or average sleep, the scores being 5, 6, and 7 for a count of 10. Higher number of patients were affected with hypertension (N=48). When comparing the physical, emotional and...
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Posted by admin on Oct 31, 2015 in |
Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Type 2 diabetes causes the combination of resistance to insulin action and an inadequate compensatory insulin secretory response. The degree of hyperglycemia sufficient to cause pathologic and functional changes in various target tissues, but without clinical symptoms, may be present for a long period of time before diabetes is detected. Long-term complications of diabetes include retinopathy with potential loss of vision; nephropathy leading to renal failure; peripheral neuropathy with risk of foot ulcers, amputations, and Charcot joints; and autonomic neuropathy causing gastrointestinal, genitourinary, and cardiovascular symptoms and sexual dysfunction. Patients with type 2 diabetes have an increased incidence of atherosclerotic cardiovascular, peripheral arterial, and cerebrovascular complications. Aim: The aim of this study was to determine the association between plasma human cartilage glycoprotein 39 (YKL-40) and glycated hemoglobin (HbA1C) in type 2 diabetic patients. Materials and methods: Thirty type 2 diabetic patients with the age group of 35 to...
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Posted by admin on Oct 31, 2015 in |
Diarrhoea is a condition that involves frequent passing of loose or watery stools. According to the WHO, approximately 3.5million deaths each year are attributable to diarrhoea. Medicinal plants have been used as traditional remedy for diarrhoea for years long and there is renewed interest from the discovery of novel compounds from plants to flight against diarrhoea. WHO also encourages studies on diarrhoea which include research on traditional herbs. The present study was designed to investigate antidiarrhoeal potential of leaf extracts of Ocimum sanctum (Lamiaceae. The present study is aimed to evaluate the leaf extracts of Ocimum sanctum (Lamiaceae) for acclaimed anti-diarrhoeal activity using albino rats. Anti-diarrhoeal activity of Ocimum sanctum was evaluated by castor oil-induced diarrhoea in rats. Loperamide was used as a standard drug. The study revealed that, the alcoholic extract and aqueous extract of Ocimum sanctum possessed significant antidiarrhoeal activity in castor oil-induced diarrhoea, compared to the control group. Ocimum sanctum showed significant anti-diarrhoeal activity as compared to loperamide and can be recommended for further...
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Posted by admin on Oct 31, 2015 in |
Background: The Influenza viruses are major etiologic agents of human respiratory infections, and inflict sizable health and economic burden. Methods: The present study reports the in-vitro antiviral effect of isolated alkaloidal compound of Jatropha curcas leaves against Influenza virus by Hemagglutination (HA) reduction assay in two different layouts of simultaneous and post-treatment assay. The alkaloidal compound was used for anti-influenza activity in the non-cytotoxic range. The separated compound (Rf 0.5) was eluted, crystallised and identified by using NMR and FTIR analysis and co-TLC with standard compound of Tetra Methyl Pyrazine(TMP). Results: The Thin Layer Chromatographic analysis showed that ethyl acetate: dichloromethane (1:1) was the best solvent for alkaloidal separation. The identified Tetra-Methyl Pyrazine showed 100% reduction in HA in the post-treatment assays at the concentration of 10mg/ml and 5mg/ml. In simultaneous assay, HA was reduced to 71% and 42% at concentration of 10mg/ml and 5mg/ml respectively. Conclusions: These results suggest that TMP has strong anti-Influenza virus activity that can inhibit viral attachment and/or viral replication and may be used...
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