Posted by admin on Sep 30, 2015 in |
Aim of the present study was a comparative evaluation of antianxiety activity of three traditionally used medicinal plants — Argyreia speciosa (Roots), Caesalpinia digyna (Roots) and Sphaeranthus indicus (Flowers). The activity of various extracts (petroleum ether, chloroform, ethanol and water) of all the three plants was evaluated using elevated plus-maze model. The studies were conducted on lacca mice, and the test materials were administered per oral route. Results indicate that the ethanol extract of C. digyna roots exhibited maximum and significant dose dependent effect at 200 and 400 mg/kg on elevated plus-maze, the results were comparable to the standard antianxiety drug diazepam (2...
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Posted by admin on Sep 30, 2015 in |
The pharmacological activity of Withenia somnifera commonly called Ashwagandha, a herb having multi-medicinal properties, was investigated against carbofuran exposed hepatic anomalies in the air breathing fish Clarias batrachus. Fishes were exposed to 1 mg/L carbofuran for three weeks to induce the toxic effects. These fishes were then fed with Withenia somnifera root extract mixed pelleted feed @ 10% of the total feed ingredients for the next 6th and 8th week respectively. The histopathological examination of hepatic tissues was done on light microscopy and transmission electron microscopy. Major changes attributed to the hepatic cells after carbofuran treatment showed irregular shape of hepatic cells, increased sinusoidal spaces, rough endoplasmic reticulum, secretary granules, dilated mitochondrial cristae and presence of kupffer cells. Amoeboid nucleus with increased heterochromatin material, granular nucleoplasm and enlargement of nucleolus, were some of the prominent histopathological alteration in the liver tissue after carbofuran toxicity at transmission electron microscope (TEM) level. The histopathological examination of liver cell of carbofuran exposed fish followed by administration of W.somnifera root extract mixed pelleted...
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Posted by admin on Sep 30, 2015 in |
Objective: To evaluate hypoglycemic responses of Kasni (Cichorium intybus) seed preparations in combination with oral hypoglycemic agent in treatment of patients of newly diagnosed type2DM. Methods: Newly diagnosed 90 patients of type2DM, age 35-65years, of either sex were divided into 3 groups. Each group had 30 patients (19 male and 11 females) matched with each other in terms of age and sex. In group A, only Glycomet SR once a day and in group B/C 6 grams crude seed powder or 50 ml decoction of crude seed powder twice a day in combination with Glycomet SR once in a day, was given for 90 days. FBG and PPBG were measured across 7 time periods and HbA1c levels were measured at zero and 90th day. Results: All the three groups shown a significant reduction in FBG and PPBG across the seven time periods. Post hoc TukeyHSD test shown that there was a significant difference between group A&B (p=0.027) and group A&C (p=0.000) for FBG and group A&B (p=0.019) and group...
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Posted by admin on Sep 30, 2015 in |
The use of natural products for the treatment of various diseases has a long history. In the present study, the anti-oxidative, cytotoxic and phytochemical properties of ethanol extract of a local variety of Piper betle leaves cultivated in Potia, Bangladesh has been investigated. The antioxidant and cytotoxic activity of the Piper betle ethanol extract were evaluated by DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging method and brine shrimp lethality bioassay method, respectively. Preliminary phytochemical group tests were also done to investigate the phytochemical properties of the extract. Leaf extract showed significant DPPH free radical scavenging effect compared to standard antioxidant ascorbic acid. IC50 value of ascorbic acid and leaf extract was found 1.81μg/ml and 151.36μg/ml respectively. In brine shrimp lethality bioassay LC50 value of Piper betle ethanol extract was found 274.63862µg/ml with 95% confidence limit where the lower and upper limits were 198.39 µg/ml and 387.18µg/ml respectively, which indicates that the Piper betle leaf extract has promising cytotoxic effect. Phytochemical analysis was found to be positive for alkaloid, glycosides, terpenoids,...
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Posted by admin on Sep 30, 2015 in |
A simple, reproducible and economical UV spectrophotometric method was developed for determining the potency of ciprofloxacin HCl in tablet dosage forms marketed in Bangladesh. Standard curves of ciprofloxacin HCl in the media of 0.1N HCl and distilled water were obtained by plotting absorbance versus concentration where calibration curve was found to be linear (r2>0.99). The average potency value for seven tablet samples (C1, C2, C3, C4, C5, C6 and C7) measured by HPLC method was 99.08±0.60% for 0.1 N HCl taking the absorbance at 277nm and 98.76±0.69% in case of distilled water at 276 nm, whether the value determined by this UV spectrophotometric method was quite satisfactory being 98.15±0.76% and 97.64±0.71%, respectively. In a separate experiment, efficiency of this method in practice was checked by determining the thermostability of ciprofloxacin HCl to find out how severely that degrades in high temperature conditions. Development of such economical UV spectrophotometric method will encourage low-investing pharmaceutical companies to employ this alternative method in quality control laboratories for routine analysis of ciprofloxacin...
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