Posted by admin on Aug 31, 2015 in |
In the present work, a prodrug (2) of aceclofenac was synthesized using N-hydroxymethylisatin (1) as promoiety. Its structure was established on the basis of modern analytical techniques. An analytical, rapid, cost-effective and accurate method using UV-spectroscopy has been developed for the synthesized prodrug. The results and calibration curves obtained with different solvents for the prodrug revealed that the method developed was precise and...
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Posted by admin on Aug 31, 2015 in |
To investigate the effects of ginger-juice (Zingiber Officinale Roscoe) on rat’s intestinependular motility. Methods: Albino rats were sacrificed to isolate intestine. Concentration of ginger is expressed in term of mg/ml of ginger rhizome. It is based on preparation of ginger-juice as detailed in material and methods section. 150 ml of filtrate used in the isolated experiment represented 500 gm of ginger rhizome. The diluted filtrate was used in the “in vitro” experiment. Result: G.J.F produced significant pendular motility in isolated rat...
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Posted by admin on Aug 31, 2015 in |
Research with plants and plant derivatives are increasing day by day for the discovery of therapeutic and nutraceutical agents from them and due to the versatile applications of those beneficial agents. The present study was thus designed to investigate the antioxidant and cytotoxic properties of methanolic Averrhoa carambola L. fruit extract along with the identification of the phytochemicals present in the extract. The antioxidant activities were determined by several assays: determination of total phenol content, assessing total flavonoids content, total antioxidant capacity assay and DPPH free radical scavenging assay. The in-vitro cytotoxic activity of fruit extract of Averrhoa carambola L. was determined by Brine Shrimp Lethality assay (BSLA). Preliminary phytochemical screening confirmed the presence of alkaloids, flavonoids, phenolics, carbohydrate, saponin, tannin in the methanolic extract of Averrhoa carambola L. fruit which was indicative of possible antioxidant and cytotoxic activity. The extract showed good antioxidant activities having total phenol content of 21.316±0.372 mg GAE/gm, total flavonoid content of 23.058±2.059 mg QE/gm, total antioxidant capacity of the extract was 152.368±2.791 mg...
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Posted by admin on Aug 31, 2015 in |
Efavirenz is a crystalline lipophilic solid with a low aqueous solubility and intrinsic dissolution rate. It is classified in class II of the Biopharmaceutics Classification System, which means it is poorly water-soluble and highly permeable. Spray drying is a widely used manufacturing process wich uses the aerosol phase to dry particles. By modifying the spray drying operation parameters, it is possible to control the properties of spray dried particles towards enhancement of drug bioavailability and delivery. Most studies use organic solvents but some of them have already been prepared as water based systems. We propose the use of water as solvent, since the use of organic solvents is increasingly contraindicated in pharmaceutical industry. The use of water, normally do not generate amorphous systems for low soluble drugs, increasing wettability and drug dissolution, do not leading to stability concerns. The results obtained demonstrate that co-spray-drying of EFV:SLS and EFV:PVP samples is an effective technique in the enhancement of efavirenz dissolution, in a process industrially viable. Different from results previously obtained...
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Posted by admin on Aug 31, 2015 in |
Crude extract from the leaves of Hedera colchica (C. Koch) C. Koch proved to have an antiulcer activity in pharmacological experiences. Hederacolchisid F (HCF) is being the chemical marker of this plant, a simple and reliable HPLC method is developed for the quantitative evaluation of the extract using this compound. The chromatographic separation was achieved using an Eclipse XDB-Phenyl column C-18 (4.6 x 250 mm; 5 mm). The UV detection is performed at 205 nm. All separations were realized at 20°C. The proposed HPLC method is linear in the range studied (r2> 0.999) for all the analytes. The method is precise with intra- and inter-day variations of less than 1.03%. Precision, sensitivity and linearity are satisfactory in the range studied. Accuracy 99,8±0,9%. The developed HPLC method can be used for the quality control of crude extract from the leaves of Hedera...
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