Posted by admin on Jun 30, 2015 in |
The present study is about the pharmacognostic and phytochemistry study on Dillenia indica Linn. Dillenia indica is commonly known as chalta or chilta in Hindi. It is a medium sized tree, a native of South eastern Asia, India, Bangladesh, East Srilanka, South western China and Vietnam. The plant is evaluated for understanding the pharmacognostic and Phytochemical characteristics of the leaf. The physicochemical parameters were evaluated which revealed the moisture content as 10.71%. Water soluble and alcohol soluble extractives was found to be 11.97% and 42.32% respectively. Total ash content, water soluble ash content and acid insoluble ash content was found to be 17.48%, 14.03% and 10.56% respectively. Phytochemical analysis revealed the presence of Alkaloids, Glycosides, Steroids, Flavonoids, Tannins, Saponins and Phenolic compounds. TLC and HPTLC analysis revealed the presence of various phyto-constituents along with Flavonoids, Steroids and Amino acids. HPTLC analysis revealed the presence of Quercetine, Kaempferol, Cholesterol and Glutamic acid. Detection was done under 254 and...
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Posted by admin on Jun 30, 2015 in |
Vinca alkaloids are a subset of drugs obtained from the Madagascar periwinkle plant, Catharanthus roseus and have hypoglycemic as well as cytotoxic effects. They are used for treating diabetes, high blood pressure and have been used as disinfectants. The vinca alkaloids are important for being cancer fighters, as they work by inhibiting the ability of cancer cells to divide. Upon acting on tubulin, they prevent the formation of microtubules, an essential component for cellular division. . There are four major vinca alkaloids in clinical use: Vinblastine (VBL), vinorelbine (VRL), vincristine (VCR) and vindesine (VDS). Vinblastine is most often used to treat breast cancer and germ cell tumors. Vinorelbine has exhibited significant antitumor activity in patients with breast cancer and anti proliferation effects on osteosarcoma (bone tumor cells). Vincristine is FDA approved to treat Wilm’s tumor, acute leukaemia and other lymphomas. Vindesine is used in the treatment of melanoma, lung cancers and uterine cancers. Vinflunine is used for the treatment of second-line transitional cell carcinoma of the urothelium. In the...
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Posted by admin on Jun 30, 2015 in |
Herein method for the synthesis of substituted 1,2-benzoxazolone (8a-f) and 3-chloro-1,2-benzoxazole (9a-f) derivatives has been described. A new scheme has been adapted for the construction of 1,2-benzoxazole ring from salicylic acid and its derivatives which leads to the formation of series of 5,6 and 7 substituted title compounds. Synthesized compounds were characterized by IR, 1H-NMR and Mass spectral analysis. Spectral data confirmed the compounds formation. Final compounds (8a-f) and (9a-f) were screened for their in-vivo analgesic activity by acetic acid induced writhing method in rats and anti-inflammatory activity by carrageenan-induced paw edema model. Among the compounds screened compound 8a and compound 9c showed good analgesic activity of about 45% (writhing mean 8.9) and 54% (writhing mean 7.5) inhibition respectively at 5 mg/Kg po dosage. Compounds 8b and 9b (both having inhibition edema of 66.1%) showed significant anti-inflammatory activity. Other derivatives exhibit moderate to good analgesic and anti-inflammatory...
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Posted by admin on Jun 30, 2015 in |
We intended desired ointment developed for bacterial infection. So Levofloxacin is a fluoroquinolones of antibacterial drug effective in the treatment of bacterial conjunctivitis, sinus, kidney, bladder or prostate Here the main objective of the present work is besides delivering drugs to the body, A drug delivery system to improve patient compliance and dispersible are no exception. So we have selected the topical drug delivery system by using a formulation of ointment. The Levofloxacin ointment is prepared by the two ointment bases, namely Oleaginous and Emulsion bases. To assess the efficiency of Levofloxacin ointment by physical appearance, viscosity, PH and spreadibility, Rheological properties and micro biological studies. The Oleaginous base prepared by using white bees wax and petrolatum and emulsion base having the methyl paraben, propyl paraben, sodium lauryl sulfate, propylene glycol, stearyl alcohol white, white petrolatum, purified water. The % of drug content of Levofloxacin was found to be 99.53. The PH was found to be 5.1 % colour was found to be formulation A (Oleaginous) is light yellowish...
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Posted by admin on Jun 30, 2015 in |
There are millions of micro-organisms around us, amongst 20-25% are non pathogenic. Pathogenic microbes present in the environment around us are responsible for various health related problems. Reducing microbial load to non-pathogenic levels may be the purpose of traditional fumigation techniques like Dhoopana, Homa, and Havana etc. This is also evident from Ayurvedic literature wherein fumigation is indicated for sterilisation of operation theatres as well as labour theatres and also in wound management. Taking all these into consideration, in present study an attempt is made to estimate anti microbial effect of Dhoopana of an indigenous fumigation formulation ‘DHUP’. Two rooms of same size which are in routine usage in almost similar fashion were selected for the study. One room served as control without any intervention. In the second room Dhoopana was performed once daily for two days. In both the rooms agar gel plates were exposed at selected places and efficacy of DHUP Dhoopana was noted at selected intervals. The microbial load was estimated and subjected to statistical analysis....
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