Posted by admin on Mar 30, 2015 in |
Aim of this study was to compare bupivacaine heavy ( 0.5% ) 3ml with isobaric ropivacaine (0.75% ) 3ml, intrathecally in patients posted for lower abdominal and lower limb surgery for sensory and motor effects and hemodynamic stability. 100 patients aged 12 years or older (ASA grade I, II, III) scheduled for various lower abdominal and lower limb surgeries were randomly distributed in two groups. In group B (n= 50) 15 mg of hyperbaric bupivacaine (0.5%, 3ml) and in group R (n=50) 21.5 mg of isobaric ropivacaine (0.75%, 3ml) was given intrathecally. All observations were recorded and analyzed statistically by using unpaired t-test and P- value < 0.05 was considered significant. No statistically significant difference in onset of sensory blockade up to T10, onset of motor block (grade “I”), mean duration of analgesia and side effects was observed between both groups. Statistically significant difference in onset of motor blockade at grade “III” was observed between group B and R. Statistically significant mean duration of sensory and motor blockage was...
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Posted by admin on Mar 30, 2015 in |
Ethnopharmacological relevance: A preliminary ethnobotanical survey of diabetic patients in Health Community Centre Sering, Medan, North Sumatera, Indonesia from 2010-2011 revealed Syzygium polyanthum (Wight) as the most commonly used herb in the traditional management of diabetes mellitus. Yet, no substantial pharmacological evidences are available to validate this claim. Material and methods: A survey on the traditional herbs used among 264 diabetic outpatients attending the Health Community Centre Sering, Medan, North Sumatera, Indonesia was carried out from January 2010-April 2011. The most commonly used herb was then extracted serially with petroleum ether (PEE), chloroform (CE), methanol (ME) and water (WE); and the extracts were used for detailed anti-diabetic evaluation in both non-diabetic rats (NDR) and streptozotocin-induced diabetic rats (SDR). Results: The most commonly used herb was Syzygium polyanthum (Wight) leaf. In NDR, the increasing on blood glucose levels (BGLs) of intraperitoneal glucose-loaded rats (1g/kg) were not significantly altered by PEE, CE, and ME (1 g/kg) within 120 minutes after glucose loading. However, the BGL in WE group was significantly altered...
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Posted by admin on Mar 14, 2015 in |
Acute convulsive disorders are the most frequent neurological disorders in children which require emergency drug treatment. Immediate management of a convulsive episode is must as, delay can lead to status epilepticus, which is a significant cause of neurological morbidity and mortality among children. Benzodiazepines especially diazepam is often used as first line and routinely administered intravenously, but this is not a practical route in many peripheral health care facilities. Midazolam by buccal route is another upcoming mode of treatment in view of difficulties associated with securing an intravenous line in convulsing children with motor activity especially at peripheries, homes or even at schools. Being a developing country, malnourished group forms a significant number in our clinical practice so it was worthwhile to examine the issue of buccal midazolam’s safety and efficacy in this subset of malnourished children. It was a prospective double blind randomized control trial. Total 80 children who fulfilled the inclusion criteria were randomly allocated by a computer generated table. One group received buccal midazolam and the...
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Posted by admin on Feb 28, 2015 in |
In-vitro antibacterial and antifungal activity of Tridax procumbens plant parts (leaf and stem) were investigated by agar well diffusion method. The petroleum ether, methanol and aqueous extracts of the plant parts were tested against two bacterial strains i.e., Bacillus subtilis and Escherichia coli and two fungal strains i.e., Trichoderma reesei and Fusarium oxysporium. The results of antibacterial activity showed that methanol extract was effective and aqueous extract was devoid of any significant activity. Methanol extract of Tridax procumbens showed maximum antifungal activity. The results lend credence to the folkloric use of this plant in treating microbial infection and showed that Tridax procumbens leaves and stem could be exploited for new potent antimicrobial...
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Posted by admin on Feb 26, 2015 in |
A simple, rapid, sensitive, precise, accurate and economic isocratic stability indicating RP-HPLC chromatographic method was developed and validated for the simultaneous estimation of Glimepiride and Ezetimibe in bulk and tablet dosage form. The method was developed through a Hypersil ODS C18 (150mm x 4.6 mm, 5m) column, mobile phase comprised of phosphate in water as buffer PH adjusted to 4.8 with tri ethylamine, acetonitrile in proportion ratio 30:70v/v and at the flow rate of 1 ml/min. GLM and EZE were eluted at acceptable retention times of 3.328 and 2.322 minutes respectively with good resolution by monitoring UV detection at 237 nm. Calibration plots were linear in the concentration range of 2.5-15 µg/ml for GLM and 25-150 μg/ml for EZE with correlation coefficient(r2) 0.999 and 0.999 respectively. The total run time is 6 min. The studies were carried out by conducting deliberate degradation of the sample with exposure to stress conditions like acidic (1M HCl), alkaline (1M NaOH), 1050C heat, oxidizing agents (H2O2) and water. This method was validated and...
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