Posted by admin on May 30, 2015 in |
The ligands bis-(benzimidazolyl)pyridine (BBIP) and bis-(benzimidazolyl)benzene (BBIB) have been used to synthesize Copper(II) complexes [Cu(BBIP)2]Cl2 and [Cu(BBIB)2]Cl2 respectively. The complexes are characterized by analytical and spectral (FTIR, 1H NMR and electronic) techniques. IR spectra of complexes show that the tertiary nitrogens in the ligand are involved in the co-ordination to the metal ion. An octahedral geometry has been suggested for the complexes and the molar conductance values reveal them to be 1:2 electrolytes. The TGA curves of the complexes[Cu(BBIP)2]Cl2 and [Cu(BBIB)2]Cl2 show no mass loss upto 200°C which indicates the absence of lattice as well as co-ordinated water. The ligand BBIP and [Cu(BBIP)2]Cl2complex exhibit good antifungal and antibacterial activity against Candida albicans and Staphylococcus aureus (gram positive), Escherichia coli (gram negative) respectively, by using modified Kirby-Bauer disc diffusion method. The screening results for anti-proliferative activity for the MCF 7 breast cancerous cells show promising activity. The [Cu(BBIP)2]Cl2 complex has enhanced growth inhibition in a dose-dependent...
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Posted by admin on May 30, 2015 in |
In order to protect from UV radiations, naturally occurring safe and broad spectrum components are desired. The chemical sun blockers viz. ZnO and TiO2 gives broad spectrum UV protection but, its safety is doubted. Aim of present communication was to study UV protective activity of water immiscible pigments of fruit rinds of Garcinia indica. Out of various extracts used for sun protective activity n-butanol, and ethyl acetate extracts of fruit rinds were shortlisted. Both the ethyl acetate and butanolic extracts were fractionated with water to remove the Hydroxy citric acid present in the extract. The ethyl acetate extract after water fractionation exhibited three-fold increase in UV absorbance in both UV A and UV B regions. Fractionated ethyl acetate extract was incorporated in sun protective cream formulation and the Sun protection factor was found to be 3.43 with boot star rating of five. The fractionated ethyl acetate extract of G. indica can be used as natural component for...
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Posted by admin on May 30, 2015 in |
A simple, sensitive, highly accurate method has been developed for the determination of Lafutidine in bulk sample and dosage forms. This method is based on the oxidative coupling reaction of drug with 3-methyl-2-benzothialinone hydrazine hydrochloride (MBTH) reagent in the presence of ferric chloride to form green colored chromogen exhibiting maximum absorption at 630 nm. Beer’s law was obeyed and quantitative results were obtained in the range of 1-18µg/mL. The results of the analysis for the methods have been validated...
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Posted by admin on May 30, 2015 in |
The present study deals with the efficacy of Tribulus terrestris (TT) on aluminium chloride (AlCl3) – induced alterations in the reproductive organs and fertility of the male laboratory mouse. Thirty adult male mice were divided into six groups of five each. Group I served as control while that of II, III and IV received various doses of AlCl3 (25, 50, 100 mg/kgBW/day, respectively), for 30 days. The mice of groups V and VI were administered with TT (100mg/kgBW/day) only and AlCl3 (100mg/kgBW/day) along with TT (100mg/kgBW/day) respectively, for the same duration. Only high dose of AlCl3 (100mg/kgBW/day) – treated mice showed significant reductions in the body weight, sex organs relative weight, sperm count, motility, viability, epididymal sialic acid, seminal vesicular fructose, serum testosterone, antioxidant enzymes (SOD, Catalase, GPx), mating ability and fertility. However percentage of abnormal spermatozoa in the epididymis and level of testicular cholesterol and MDA were significantly increased. Dose-dependent regressive histological changes in the seminiferous tubules and the Leydig cells were also noticed. Supplementation with TT in...
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Posted by admin on May 30, 2015 in |
As a result of tremendous efforts in past few decades, various techniques have been developed in order to resolve solubility issues. However, majority of these techniques offer benefits associated with certain drawbacks; majorly including low drug loading, physical instability on storage and excessive use of environmentally challenging organic solvents. Hence, current effort was to develop an eco-friendly technique using liquid salt, which can offer improvement in dissolution while maintaining long term stability. The liquid salt formulations of poorly soluble model drugs ibuprofen, gemfibrozil and indomethacin were developed using 1-Ethyl-3-methylimidazolium ethyl sulfate (EMIM ES) as a non-toxic and environmentally friendly alternate to organic solvents. Liquid medications containing clear solutions of drug, EMIM ES and polysorbate 20, were adsorbed onto porous carrier Neusilin US2 to form free flowing powder. Liquid loading as high as 70% w/w was achieved while maintaining good flowability and compressibility. The liquid salt based formulations (LSF) demonstrated greater rate and extent of dissolution compared to crystalline drugs. The LSF samples exposed to 40°C/80% RH for 8 weeks,...
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