Posted by admin on Mar 30, 2015 in |
The present study discussed the nutritional content and quantification of eleven bioactive phenolic antioxidant contents in the water, methanol and acetone extracts of four different edible fruits viz. Musa acuminate (banana), Ananascomosus (pineapple), Psidiumguajava (guava) and Malusdomestica (apple) using HPLC-DAD. Nutritional analysis showed that the most moisture and fiber-containing fruit was guava where as banana had the lowest amount. On the other hand banana had the highest percentage of protein and carbohydrate whereas guava had the lowest percentage. The result showed that the antioxidant content determined by HPLC was varied in the water, methanol and acetone extracts of these fruits. According to the study, acetone was appeared as the most suitable extraction system of phenolic antioxidants present in these fruits, i.e. in the apple,(+) catechin hydrate was 486.80 ± 16.75, 28.64 ± 2.21and 0.0 ± 0.0 mg/100g of the extract; ellagic acid was 1735.14 ± 33.17, 33.44 ± 4.07 and 0.0 ± 0.0 mg/100g of the extract and (-) epicatechin was 138.02 ± 7.69, 6.78 ± 1.06 and 0.0...
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Posted by admin on Mar 30, 2015 in |
Leaves, rootstock, fruit and decoction of Lasia spinosa (Araceae) are used in folklore medicine for Gastrointestinal, Respiratory and Skin diseases. The intent of the present study was to evaluate the Antihyperlipidemic activity of methanolic leaves extract of Lasia spinosa and for its role in the prevention of hyperlipidemia induced pancreatitis in rats. The evaluation of the Antihyperlipidemic activity and the role of Lasia spinosa in the prevention of hyperlipidemia induced pancreatitis were done by means of Cholesterol 100 mg/kg body weight, p.o, induced hyperlipidemic model and Triton-X 100 (480 mg/kg, b.w; i.p.) induced hyperlipidemic model. The biochemical parameters such as Total Cholesterol, Triglycerides, LDL-C, HDL-C, VLDL-C, Serum Amylase, Serum Lipase and WBC Count were estimated to appraise its activity. A significant increase in the levels of biochemical and biological parameters was discerned in group 2 and a reversal in the extent was seen in the treated group of animals engaged in the study. The histopathological evaluations of Liver and Pancreas samples were in support of the obtained results. Based...
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Posted by admin on Mar 30, 2015 in |
The pulsatile drug delivery works upon the system that releases active pharmaceutical ingredient completely and rapidly after a desired lag time. This type of approach was advantageous for: Drugswith extensive first pass metabolism and biological tolerance. Locally absorbed or acting drugs to a specific site in the intestinal tract (e.g. colon). Adaptation of therapy according to chronopharmacological needs. The pH-dependent polymers in pulsatile drug delivery were insoluble at low pH levels but with increase in pH solubility of polymer increases. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps: Firstly core tablet was prepared containing Nifidipine as API. Secondly core tablet was coated with polymer blend of Eudragit S100and Eudragit L100. The lag time was the time in which less than 10% of drug was released. From in vitro release study we had concluded that drug release at pH 6.8 was inversely proportional to the amount of polymer Eudragit L100, which might be due to pH-dependent solubility of...
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Posted by admin on Mar 30, 2015 in |
Bone marrow aspiration can determine the metastatic deposits, degree of cellularity and fibrosis readily. A retrospective analysis of bone marrow aspiration and biopsy, in children and adult patients with hematological anomalies, were performed in 674 cases for different indication of hematological abnormalities from January 2013 to March 2014. Cases were analyzed in detail regarding clinical, hematological examination and family history. The mean age of the patients was 38.03 years ranging from 2 years to 78 years. Among 674 cases, 58.16 percent cases were male and 41.84 percent were female with sex ratio of 1.4:1. The commonest clinical & physical symptoms were pallor (87.5%), followed by weakness & headache (47.9%) and fever (37.9%). The most frequent malignant hematological anomalies in children (99.9%) and adults (50.49%) were acute leukemia, followed by multiple myeloma (17.82%) in adults only. Normoblastic marrow represented highest number of cases both in children (21.43%) and in adults (20.86%) as non-malignant hematological disorder. Bone marrow examination helps to assess the spectrum of hematological disorder in both children &...
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Posted by admin on Mar 30, 2015 in |
Molybdenum is a trace element distributed widely in nature which plays an important role in plant and animal nutrition and in our industrial society. Molybdenum is essentially present in the enzymes nitrogenase, Xanthine-oxidase, sulphite oxidas, nitrate reductase, formate dehydrogenase and aldehyde oxidase. These enzymes are responsible for a number of catalytic reactions of redox nature. Molybdenum complexes were synthesized and characterized for their purity by various physico-chemical methods like IR, Electronic, 1H1 NMR spectral studies Antimicrobial activity of compounds against certain microbial species has been carried out by serial dilution method using BOD incubator to evaluate the MIC (Minimum Inhibitory Concentration) value on the basis of MIC value it is interpretated that Molybdenum complexes are most active as compared to ligand fragments. The DNA binding ability of the complexes was examined by using biophysical spectroscopic studies. These studies indicate that the compounds can intercalate and stablize DNA. This work has great importance in the field of bioinorganic...
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