Posted by admin on Jan 31, 2015 in |
A properly designed system will provide a high degree of assurance that every step, process, and change has been properly evaluated before its implementation. Validation is an important step carried out in order to control the entire process, and the process adapted to produce itself must assure that process will consistently produce the expected results and maintain the desired quality of the final product. Process validation is the validation of each and every step of the processes which involves series of activities carried out in order to have the assurance of the products manufactured. Each and every step should be scientifically planned, conducted and documented appropriately and for this one should have sound knowledge and understanding regarding the process as well as the product. So, the study here shows the research work done on the formulation and process validation of diclofenac sodium and paracetamol combination tablet, the critical process parameters involved in the manufacturing process and the consistency in the results of the three consecutive...
Read More
Posted by admin on Jan 31, 2015 in |
The objective of present research work is to provide green technique for synthesis of 4-(4-Hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester. Pyrimidine derivatives are well known in the pharmaceutical industry and exhibit to possess a broad spectrum of biological activities. Highly efficient and simple methods complying with principle of Green chemistry have been described in this manuscript for the synthesis with competent yields. As part of current studies, we here in report economical practical techniques like- microwave synthesis, mortal-pastel method (mechanochemistry) and by application of green solvents. On completion of reaction the products were characterized by IR, NMR and Mass Spectra. These methods are more convenient and reactions can be carried out in higher yield (80-96%), shorter reaction time (3-30 min) and milder conditions, without generation of pollution and safer to...
Read More
Posted by admin on Jan 31, 2015 in |
The present study was carried out to assess the anticancer activity of methanol extracts of internal bone of L.duvauceli and S. pharaonis for cell viability and toxicity on HepG2 liver cancer cells. The bone extracts had significant cytotoxicity on HepG2 cell in different concentrations (100,500,1000 µg/ml). Methanol fraction of squid bone powder showed cell death at a higher concentration of 1000µg. 27% toxicity was observed at 100µg/ml and 37% at 1000µg/ml. The viability of cuttlefish bone powder ranged from 58% (1000µg/ml) to 68% (100µg/ml). Hep G2 cells experienced a significant decrease in viability at low concentration with an eventual decline at the highest concentration. The percentage of toxicity of cuttle bone extracts varied from 32 to 42. Minimum toxicity of 32% was observed at 100µg and maximum of 42% was observed at 1000µg concentration and IC 50 at a concentration of >1000µg. The percentage of toxicity showed increasing trend with increasing concentration of the extract. The result suggested that the cephalopods bone is a source to be considered in...
Read More
Posted by admin on Jan 31, 2015 in |
Dugdhika is one of the important raw drug used in Ayurveda. E. thymifolia is used as the genuine source plant of drug Dugdhika, it posses properties like, used for skin disorders, sexual disorders, effective drug for asthma., diarrhoea, dysentery. The present study deals with the comparative study of morphological, anatomical, histochemical characters of E. hirta and E. thymifolia. Two plants show similarities and differences between them at morphological, anatomical and histochemical levels. Morphologically these two plants show differences in many characters. But histological studies of both plants are almost similar. The histochemical study of both plants shows differences. This study helps to identify the genuine plants of the drug Dugdhika for the preparation of Ayurvedic...
Read More
Posted by admin on Jan 31, 2015 in |
Objective: To investigate the effectiveness of Lactobacillus sporogenes in the treatment of acute diarrhoea in paediatric population. Methods: In a prospective randomized open label comparative study, 62 children (1 month– 6 years) admitted to the Medical College Hospital for the treatment of acute diarrhoea, were included. The patients were randomised into two groups, control group (n =31) receiving only fluids and zinc and test group (n =31) receiving probiotic Lactobacillus sporogenes in addition to fluids and zinc. The outcome measures were frequency of diarrhoea, consistency of stools, duration of diarrhoea after hospitalization, duration of hospital stay and side effect profile associated with the use of probiotic. The data was analysed using the SPSS software. Results: Lactobacillus sporogenes group showed statistically significant reduction in the frequency of diarrhoea on second day of treatment (mean ± SD) (Test group: 4.94 ± 2.05, Control group: 6.00 ± 2.25). In addition, a greater improvement in the consistency of stools on the second day of treatment was observed (Test group: 16.1% patients, Control group:...
Read More
