Posted by admin on Nov 1, 2014 in |
The phytochemical screening of the bark of Albizia lebbeck (L) showed positive test for tannin, alkaloid, flavonoid, terpenoid, phlabotannin, saponin, steroid and cardiac glycoside. In this article an attempt was made for biological studies (the antimicrobial activity, cytotoxicityand free radical-scavenging activity) of different extracts (hexane, methanol, ethyl acetate, water and butanol extract) of the bark of Albizia lebbeck. The antimicrobial sensitivity of the extracts was tested using the disc diffusion method. The cytotoxic effects of five extracts (hexane, methanol, ethyl acetate, water and butanol extract) of the bark of Albizia lebbbeck were carried out. Free radical scavenging activity of the bark of Albizia lebbeck was performed. All the extracts showed moderate anti microbial activity and gram positive bacteria were more sensitive than gram negative bacteria. Significant cytotoxic activity was noticed and hexane extract was found the most lethal to brine shrimp nauplii. This result revealed that the highest cytotoxic constituent may be non polar in nature. Good free radical scavenging activity was observed in all the extracts, and...
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Posted by admin on Nov 1, 2014 in |
The present paper deals with a novel approach in formulating and characterizing mucoadhesive buccal patches with the incorporation of herbal extract. In the present arena of Novel Drug Delivery System, delivery of drugs through buccal mucosa serves an easier method for utilization of drugs leading to reduction of dose frequencies and thereby tends to sustain the drug release. Buccal patches were prepared with herbal (Neem) extract with two polymers such as Methyl Cellulose and Hydroxy Propyl Methyl Cellulose in a respective solvent such as Ethanol with Propylene glycol as the plasticizer. Buccal patches were successfully formulated by solvent casting technique with several concentrations of polymers and those prepared patches were characterized in terms of film thickness, film weight, colour, surface texture, folding endurance, surface pH, swelling behaviour and percentage of moisture loss. Percentage of drug content in all patches was also determined and all patches showed their significant properties upon characterization and there was uniformity in drug content for all patches. In-vitro drug diffusion studies were carried out using...
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Posted by admin on Nov 1, 2014 in |
A facile synthesis of novel 2-amino-1,2-dihydroisoquinoline-3(4H)-one and their amide derivatives (6a-o) through sydnone intermediate (3) was derived from tetrahydroisoquinoline-3-carboxylic acid (1) and various substituted phenyl acrylic acid derivatives (5a-o) in short reaction time with good yield. The structure of all novel synthesized compounds was established based on Mass, 1H NMR, 13C NMR, IR spectral data and Single crystal X-ray study (6e). All the synthesized compounds were evaluated for their antimicrobial and antioxidant...
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Posted by admin on Nov 1, 2014 in |
Context: Drug treatment during pregnancy presents a special concern. All drugs should not be avoided. A better knowledge of parameters that determine teratogenicity may allow the physicians gain confidence. Aims: This study was conducted to understand the drug utilization practices during pregnancy in women from rural areas and poor socioeconomic background; classify them according to US-FDA category for determining the teratogenic potential; to provide feedback and recommendations to the health care providers. Settings and Design: This was a retrospective cross-sectional study carried out at rural tertiary hospital. Methods and Material: Case record forms of 300 patients admitted to the obstetrics ward from September to November 2009 were analyzed for demographic details, drug prescriptions and drug utilization patterns. The teratogenic potential of drugs was analyzed according to US-FDA risk categories for drugs and medication. Statistical analysis used: Statistical software SPSS was used for analysis. Results: Maximum prescriptions happened in the second trimester of pregnancy. Vitamins, mineral and nutritional supplements were prescribed in almost 100% cases. The patients receiving more than...
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Posted by admin on Nov 1, 2014 in |
Medicinal plants contribute in human health care system. Most of the plants utilized by village peoples as a folk medicine. The effects of plant extracts on bacteria have been studied by a very large number of researchers in different part of the world. In this study antimicrobial activity of Acalypha indica were investicated against two strains of Human pathogenic bacteria. A total of 15 pus samples were collected from Namakkal private hospital, among that two strains were isolated as Staphylococcus aureus and Pseudomonas aeruginosa. Isolation and identification of bacterial isolates by using standared biochemical tests. The above isolated organisms were tested for their sensitivity towards the Acalypha indica medicinal plant leaves extract by disc diffusion and Agar well methods. In this study the highest antibacterial activity were observed in water extract of Acalypha indica than compared with acetone extract. Inhibitory effect of medicinal plant against Staphylococcus aureus in well diffusion is (17mm), and Psedomonas aeruginosa is (20mm) in water extract. In acetone extract 7mm, 9mm inhibitory zone showed by...
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