Posted by admin on Oct 1, 2014 in |
The present study compiled the formulation and standardization of polyherbal liver syrup named “LivPro” followed by in-vivo and in-vitro hepatoprotective activity in CCl4 intoxicated rat. LivPro was formulated by using the lyophilized ethanolic extract of A. millefolium, C. spinosa, C. intybus, and P. kurroa. Further, the standardization of LivPro was performed following the guidelines of WHO and Indian Pharmacopoeia. Wistar albino rats were treated with vehicle, silymarin, and LivPro (5, 10 and 15 ml/kg) continuously for 14 days. CCl4 was administered on every alternate day for a week. Results postulated that LivPro had pH 5.04, specific gravity 0.8269; viscosity 78.01 poise, relative density 1.271 gm/ml, and refractive index 1.432. LivPro showed a rich quantity of flavonoid (480 mg/gm), total phenol (396 mg/gm) and alkaloid (103 mg/gm). The concentration of lead and arsenic in the tested formulation was found to be within the limit. The total plate count and viable aerobic microbial count in the formulation were 480, and 415 CFU/gm and the yeast and mold count was less than 100...
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Posted by admin on Oct 1, 2014 in |
Spontaneous reporting of adverse drug reactions (ADRs) is a broadly experienced technique of practicing pharmacovigilance (PV) activity. However, the progression of pharmacovigilance programs is limited by under-reporting of ADRs, as it is considered one of the major problems associated with PV programs development. This is the first study of its kind in the United Arab Emirates (UAE) that examines what inhibits and what motivates the community pharmacists (CPs) to report ADRs. Face to face questionnaire was used for data collection. Random sampling method was used to approach the potential respondents. Descriptive analysis was conducted using SPSS 20. Many barriers had been revealed that prohibit pharmacists participation in PV program; unavailability of reporting forms (81.8%), unknown address to contact (79.8%), the belief that all serious ADRs are detected before registration (70%), pharmacists unfamiliarity of how to report (69.1%) were the commonly shared reasons for under-reporting by CPs. Also, the majority (82.1%) of the respondents agreed that encouraging patients to report ADRs to the pharmacists is an important factor necessary for...
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Posted by admin on Oct 1, 2014 in |
Quantitative Structure-Activity Relationships (QSAR) is based on the assumption that the activity of a certain chemical compound is related to its structure. More precisely, this approach says that the activity or the property is related to the chemical structure through a certain mathematical algorithm or rule. Quantitative structure-activity relationship (QSAR) analysis used to understand the structural factors responsible for PPAR-γ agonistic activity of some 2- Alkoxydihydrocinnamates. Several pharmacophore-based models indicated the importance of steric, hydrophobic, and hydrogen bond acceptor groups to agonistic...
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Posted by admin on Oct 1, 2014 in |
The present study was aimed to screen the antioxidant activity and phytochemical content of bryophyte species Marchantia paleacea Bertol., Marchantia linearis Lehm. & Lindenb. and Conocephalum conicum (L.) Underw. collected from Darjeeling hills of Eastern Himalaya, India. The free radical scavenging activities were measured in-vitro by DPPH radical, metal chelating, superoxide, ABTS+, reducing power, anti-lipid peroxidation, and nitric oxide scavenging activity. Total phenol, flavonoids, and ortho-dihydric phenol present in the samples were also estimated. Qualitative phytochemical screening was carried out to detect the presence of varied phytochemicals. Thin-layer chromatography (TLC) and TLC bioautography assay were also performed to confirm the presence of different bioactive compounds and its free radical scavenging potential. All the tested bryophyte species showed potential antioxidant activity and the existence of different phytochemicals. The results obtained from this work indicated that all the three bryophyte species analyzed are a potent source for antioxidants and can be pharmaceutically explored in...
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Posted by admin on Oct 1, 2014 in |
From TLC examination of fractions of benzene and benzene: ether (5:5) extract of the stem bark of B. monosperma revealed the separable mixture. These fractions were subjected to rechromatography. Isolated compounds were purified and crystallized by chloroform: methanol. After isolation and purification afforded white crystalline substance which was subjected to physical, chemical and spectral analysis and identified as Tetratriacont -15-ene(1), Hepta cos-11-ene(2), 15-hydroxyl ethylheptadec-12-enoate(3), 10-hydroxy dodecyltridec-5 enoate(4), based on spectral evidence....
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