Posted by admin on Sep 1, 2014 in |
Aripiprazole is an anti-psychotic drug used in the treatment of psychosis, including schizophrenia, and during process development for Aripiprazole, we observed two related substances. This paper describes the preparation, identification and proposed structures of the impurities 7-(4-(4-(2-chlorophenyl) piperazine-1-yl) butoxy) – 3, 4 – dihydroquinoline – 2(1H) – one and 7- (4-(4-(3-chlorophenyl)piperazin-1-yl) butoxy)-3,4-dihydroquinoline-2(1H)-one formed during reaction of 7-(4-bromobutoxy)-3, 4-dihydroquinoline-2(1H)-one with 1-(2, 3-dichloro phenyl) Piperazine Hydrochloride to form...
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Posted by admin on Sep 1, 2014 in |
Background: High blood pressure has emerged as a leading cause of death and disability worldwide.1 Management of hypertension effectively has been a distant reality. Hypercum, a rationale combination of herbs has shown to reduce BP effectively along with other benefits as studied in the ancient literature and research publication. Objectives: The study aims to evaluate the safety and efficacy of “Hypercum” on mild to moderate hypertension, an open-labeled nonrandomized proof of concept study enrolled 16hypertensive associated with co-morbid conditions. Methods: patients who met the selection criteria. The efficacy was assessed by measuring the blood pressure at baseline and on every 15 days till the BP got controlled and then every month and followed up for 84 days. The effect of Hypercum on other co-morbid conditions was also evaluated. The quality of life was also assessed using SF-30. Planned student‘t’ test was applied. Results: At screening (before the enrollment for the study), the mean systolic blood pressure (SBP) was 161.25 mmHg, and their mean diastolic blood pressure (DBP) was 106.88...
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Posted by admin on Sep 1, 2014 in |
Endangered Indian medicinal plants have used as traditional and alternative Indian system of medicine (ISM) from last several ancient time. In 20th and 21th – century generation are becoming aware of the side effect and adverse reaction of synthetic drugs and so there is an increasing interest, Scope of innovating in herbal medicinal plants based Ayurvedic, Siddha, Unani (ASU) medicinal products. In the continuously using of Adulteration and Substitution, Spurious drugs on the place of original Indian endangered and costly ASU. Herbal medicinal plants hence today generate the major task of Indian drug regularity affaire, drug controlling approach, as well as herbal industries, face the burning problem. Resulted growing high altitude region many endangered and rare, costly original medicinal species such as these are Vatsnabh, (Aconitum Chasmanthumstapfex. Haimes), Ativishaor Atis, (Aconitumheterophylum Wall. Ex. Royal), Kutki, (Picrorhiza kurroa royleex), Kuth or Kustha, (Saussurea lappa C.B.CL.), Puskarmool, (Inularacemosa Hook.F.), Riddhi, (Hobenariainte media D. Don), Vriddhi, (Habenariaedge worthii Hook.f.ex.Collett), Kakoli, (Roseea purpurrea Smith), Kshirakakoli, (Fritillariar oylei Hook) and (Lilium polyphyllum D. Don),...
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Posted by admin on Sep 1, 2014 in |
Bio-surfactants, produced by microorganisms are important biotechnology products, owing to their modes of action, low toxicity, relative ease of preparation, and widespread applicability as an industrial, medicinal and in food industries. The present study was done to isolate the bio-surfactant producing Actinomycetes from three different types of soil samples contaminated with petroleum spillages from Naval Dockyard (NDYS), deep marine sediment from sea-bed (DMS), and with poultry litter (PLS), collected from around Visakhapatnam. Thirty isolates of soil Actinomycetes were initially screened in Humic-acid vitamin-salts agar-plates, to identify their bio-surfactant activity by Oil-displacement method. Only seven of these thirty isolates, namely, PLS-1, PLS-2, PLS-4, PLS-9, NDYS-3, NDYS-4, and DMS-1, showed promising bio-surfactant activity, compared to sodium-laryl-sulfate as standard. These seven isolates were further subjected to preliminary screening methods (modified drop collapse method, Para film-M method, and lipase activity method), to identify bio-surfactant production. Three of these seven isolates, namely, PLS-1 from poultry littered soil, NDYS-4 from petroleum contaminated soil from the naval dockyard, and DMS-1 from deep marine sediment, showed maximum...
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Posted by admin on Sep 1, 2014 in |
Flavonoid and sesquiterpene constituents of the aerial part of Cleome brachycarpa were chemically investigated and screened for their potential cytotoxicity. A flavonol glycoside; 3, 5, 4` trihydroxy-3`-methoxy flavone – 7 – O – a – L -rhamnopyranose (1“`® 2“) – O – β – D-glucopyranoside (1) and a megastigmane glucoside; (+)-(6S, 9R) roseoside (2) were isolated for the first time from the n-butanol fraction of the 90 % ethanol extract of Cleome brachycarpa. Four methylated flavonoids were isolated from the chloroform fraction and identified as 5,4`- dihydroxy-3,6,7,3′ tetramethoxyflavone (3), 5,5`- dihydroxy-3,6,7,3′,4′, pentamethoxy-flavone (4), 5-hydroxyl -3,6,7,3′,4′,5′-hexamethoxyflavone (5) and 5, 7,3′,4′ tetrahydroxyflavone (6) In addition, two sesquiterpene oxides, namely buchairol (7) and teucladiol (8) were isolated from the n-hexane fraction for the first time. Structure elucidation was achieved using spectroscopic techniques, including IR, UV, ESI-MS, EI-MS and 1D, and 2D-NMR. Each of the three fractions and isolated compounds were screened for their cytotoxicity and lethality using the brine shrimp (Artemia salina) assay. The results showed high lethality for all the examined...
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