Posted by admin on Dec 25, 2014 in |
Multiparticulate drug delivery system are mainly oral dosage forms consisting of a multiplicity of small discrete units, each exhibiting some amount desired characteristics such as pellets.The purpose of present study was to prepare sustained release robust matrix pellets of Glipizide. The study revealed successful application of factorial design, optimization of extrusion spheronization process, and sustaining release of Glipizide for formulating uniform, spherical Glipizide pellets. Speed and time of spheronization is critical parameter for optimum sphericity. The Optimum speed and time of operating spheronization is 1350 rpm and 15 min. The results of this study showed that combination of HPMC K100M LVCR as hydrophilic matrix polymer and PEG 400 as potential plasticizer is effective and useful for sustaining the Glipizide release to treat diabetes mellitus. The in-vitro studies showed Q16 at approximately 80% cumulative release in case of F4, F5, F6, It indicates that this system can sustain the release upto 24 h which is desirable for sustained release specificity. Although, the hydrophilic matrix polymer optimization is critical for drug...
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Posted by admin on Dec 25, 2014 in |
Prednisolone Sodium Phosphate (PSP) is a steroidal anti-inflammatory or immune suppressive agent. It is a sodium salt of the phosphoester of the glucocorticoid prednisolone. It is freely soluble in water; soluble in methanol; slightly soluble in alcohol and in chloroform; and very slightly soluble in acetone and in dioxane.A simple spectrophotometric method was developed for the determination of Prednisolone Sodium Phosphate in Pharmaceutical tablet dosage form. PSP exhibiting λ max at 246nm in solvent media 100% water and obeyed linearity in the concentration range of 2 to 12µg and exhibited good correlation coefficient (R2=0.999). This method was successfully applied to the determination of PSP content in four different marketed brands from local market and the results were in good agreement with the label claims. The percentage recovery was found to be 99.80±0.238. The sample solution was stable up to 10 hours.The method was validated statistically and studies for linearity, precision, repeatability, and reproducibility. Various methods for analysis of the Prednisolone Sodium Phosphate are available but are time consuming and expensive. But...
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Posted by admin on Dec 25, 2014 in |
Heterocyclic schiff bases of 2-amino-4, 6-dimethyl benzothiazole with selected heterocyclic α- hydroxy aldehyde and α-hydroxy ketones and their Cu (II) metal complexes have been synthesised. The Cu (II) metal complexes of schiff bases are reported and characterised based on elemental analysis, IR, 1H NMR, ESR, XRD, Thermal analysis, magnetic moment, and molar conductance. The molar conductance data reveals that all metal chelates of schiff bases are non electrolytes. IR spectra show that ligand is coordinated to the metal ion in a bidentate manner. From the magnetic and electronic spectral data it is found that the geometrical structures of these complexes are square planar. The activity data show the metal complexes to be more potent antifungal and antibacterial than the parent schiff base ligands against one or more fungal and bacterial...
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Posted by admin on Dec 25, 2014 in |
The present paper highlights the therapeutic uses of herbaceous medicinal plants used for various ailments by Toda tribe living in the pockets of Western Ghats of Tamil Nadu are inhabitants of Thiashola, Manjoor, Nilgiri District. A total of 32 plant species belonging to 18 families used by them as herbal medicines to treat several common diseases such as Asthma, antidote, contraceptive and night blindness, skin and stomach disorders, ulcer, common fever, rheumatism, bronchitis, cancer etc., Leaves are the most widely used plant part. During the present study it has been observed that the ethnobotanical systems and herbal medicines as therapeutic agents are of a paramount importance in addressing health problems of traditional communities. The indigenous knowledge available with these people plays an important role in quick and proper identification of natural...
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Posted by admin on Dec 25, 2014 in |
The aim of the present study was to investigate the effects of Eclipta alba leaves extract on the biochemical parameters in alloxan induced diabetic Swiss albino mice. Diabetes was induced in mice by injecting intraperitoneally alloxan monohydrate at dose of 135 mg/kg body weight. Ethanolic extracts of E. alba leaves at dose of 200 mg/kg body weight were given orally in diabetic mice daily for four weeks after established LD50 value. Our studies was extended to include the effect of the tested doses on different biochemical parameters including serum glucose concentration, transaminases and phasphatse activities, total protein, albumin, urea, uric acid, and creatinine levels in serum. In diabetic mice, serum glucose concentration, transaminases and phasphatse activities, urea, uric acid and creatinine levels were significantly increased but level of serum total protein and albumin were decreased in comparison with the control group. Diabetic mice group, treated with ethanolic extract of E. alba leaves (200 mg/kg b. wt.), on comparison with diabetic group showed a significant decrease in transaminases and phasphatse...
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