Posted by admin on Oct 1, 2014 in |
The prevalence of psoriasis has a deep negative impact on Quality of life (QoL) daily. It has been classified under psychophysiological disorders. The prime objective of the present study is to evaluate and assess the Quality of Life (QoL) of psoriasis patients in Osmanabad region of India. A retrospective analyzing study was carried out on 52 psoriatic patients attending outpatient and inpatient departments of the Government Ayurvedic College and Hospital, Osmanabad, Maharashtra state, India. The study was carried out between October 2010 to March 2011. A total of 52 patients suffering from psoriasis who had completed an assessment of disease severity and the dermatology life quality index (DLQI) questionnaire were analyzed. Of these patients, 75% were men. The mean score on the DLQI was 8.28, and almost all patients reported a moderate to extremely large impact on their quality of life (DLQI >7). A higher psoriasis area severity index (PASI), younger age, and initial lesions on the trunk, hands-legs, and scalp significantly negatively impacted patients quality of life. Psoriasis...
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Posted by admin on Oct 1, 2014 in |
To evaluate the effects of different processing parameters on drug-loaded microspheres, the solvent evaporation technique was chosen as the formulation method. Indomethacin-loaded Polylactic acid microspheres were prepared by varying drug masses, then by changing the stirring speed. They were analyzed for their drug content, physical morphology, size, polymer-drug physicochemical compatibility, and in-vitro drug release. Microspheres revealed a spherical profile along with a porous structure. The effect of changing the drug mass was noted on drug encapsulation and loading efficiencies. Indomethacin had better encapsulation when introduced in small amounts. On the other hand, the effect of changing the stirring speed was remarkable on the size of obtained microspheres and drug release profile. The particle size decreased as the speed of mixing increased. Also, a faster drug release was observed for larger...
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Posted by admin on Oct 1, 2014 in |
To evaluate the anti-diabetic effects of the Mukia maderaspatana Linn. (MML), and to explore the possible mechanism. High-fat diet and STZ (35 mg/kg) induced diabetic rats were administered with MML at two dose levels (200 and 400 mg/kg/day, p.o.) for 21 days. Fasting blood glucose, lipid and lipoprotein levels such as triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C) and glucose tolerance were tested to evaluate its anti-diabetic effects. Moreover, the preliminary study of MML on the antioxidant activity was performed. The MML possessed anti-diabetic activities as shown by the decreased serum levels of fast blood glucose (FBG), TG, TC, LDL-C, and VLDL-C, as well as increased serum levels of HDL-C. MML also improved the oral glucose tolerance test (OGTT) to a certain degree. These benefits were also associated with increased catalase (CAT) superoxide dismutase (SOD) and decreased malondialdehyde (MDA) in serum. The experimental results highlighted the hypoglycemic and hypolipidemic properties of the MML on diabetes and its complications, possibly through a...
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Posted by admin on Oct 1, 2014 in |
For reducing the gastrointestinal (GI) toxicity associated with ibuprofen (IBU), its carboxylic group was masked by synthesizing its mutual prodrugs with propyphenazone by direct coupling and by using spacer technique (amino acid was taken as a spacer). The structures of synthesized prodrugs were confirmed by 1H-NMR, 13C-NMR, Mass and FT-IR spectral methods, and their purity were established by elemental analysis. The mutual prodrugs were evaluated for their drug release behavior in enzyme-free simulated gastric fluid (SGF, pH 1.2) and simulated intestinal fluid (SIF, pH 7.4). The release of free ibuprofen from prodrugs showed negligible hydrolysis at gastric pH in SGF as compared to SIF where they undergo significant hydrolysis and thus release IBU in adequate amounts following first-order kinetics. Both IBU prodrugs were retaining anti-inflammatory activity intact and exhibited better analgesic activity along with much-reduced ulcerogenic. Prodrug IP1, however, showed better analgesic activity and negligible ulcerogenic tendency than IP2, and hence it could be considered as a better candidate for prodrug among the...
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Posted by admin on Oct 1, 2014 in |
Background and Objectives: Diabetes mellitus comprises a group of common metabolic disorders that share the phenotype of hyperglycemia. One of the leading causes of diabetes mellitus related morbidity and mortality is diabetic nephropathy. The earliest stage of diabetic nephropathy is Microalbuminuria, which is the excretion of extremely small quantities of albumin in the range of 30 – 300 mg/day. Hypomagnesaemia may be a risk factor for the progression of complications in type 2 diabetes mellitus. Material and Methods: The material for the present study comprised of 60 patients of type2 diabetes mellitus. Glycosylated hemoglobin, serum magnesium, and urinary microalbumin were measured. Results: It was found that the glycemic control, as indicated by glycosylated hemoglobin, is related significantly to microalbuminuria. Poor glycemic control leading to renal damage causes microalbuminuria. A significant inverse correlation between serum magnesium and urinary microalbumin levels was also observed. Conclusion: Estimation of urinary microalbumin, glycosylated hemoglobin and serum magnesium should be routinely done in confirmed cases of type 2 diabetes mellitus....
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