Posted by admin on Oct 1, 2014 in |
Objective: Scindapsus officinalis has been reported to have antioxidant, analgesic, anti-inflammatory, antibacterial, and antihistaminic activity. Peptic ulcer disease involves inflammation and oxidative stress. So, the present study was carried out to evaluate the potential of hydroalcoholic extract of Scindapsus officinalis fruits as an antiulcer agent. Materials and Methods: In this pharmacological study evaluation of the antiulcer effect of hydroalcoholic extract of Scindapsus officinalis fruits was performed by using pyloric ligation induced gastric ulcers model. Ranitidine (50 mg/kg p.o.) was used as standard. The preliminary phytochemical investigation, estimation of phenolic and flavonoid content and in-vitro antioxidant activity were also estimated. Results: The hydroalcoholic extract of Scindapsus officinalis fruits has a significant effect on scavenging free radicals as found in DPPH free radical scavenging assay and NO scavenging assay. In pylorus ligation induced ulcer model, the plant extract showed gastric ulcer healing effect and gastric antisecretory effect. The high dose of (500 mg/kg) of hydroalcoholic extract of Scindapsus officinalis fruits was more efficacious in reducing ulcer index. The result was supported...
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Posted by admin on Oct 1, 2014 in |
Novel Schiff base comprising 4-aminoantipyrine with Biginelli adducts of salicylaldehyde has been designed and synthesized. Solid metal complexes of this Schiff base with Ni(II), Zn(II), Cd(II) and Hg(II) metal ions were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, ESI mass, IR, NMR, and UV-Vis spectral studies. From the data, it has been observed that the complexes had the composition of ML2 type, diamagnetic nature and a tetrahedral geometry around the metal ion except for Ni(II) complex which has square planar geometry. The Ligand and its complexes have been screened for their in-vitro antifungal and in-vitro antibacterial activities against the fungi i.e., Candida albicans, Aspergillus flavus, Penicillium spp., Aspergillus niger and Trichophyton and the gram-negative bacteria Escherichia coli, Vibrio spp., Pseudomonas aeroginosa, Vibrio para haemolytic, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp. and gram-positive bacteria Bacillus spp and Staphylococcus aureus. The in-vitro antimicrobial activities of these metal complexes found to be stronger than the...
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Posted by admin on Oct 1, 2014 in |
Quantitative Structure-Activity Relationship (QSAR) for tylophorine derivatives acting as Plasmodium kinases inhibitors has been developed. The proposed 2D-QSAR model was found to be statistically significant concerning training, cross-validation, and external validation. The contribution of carbon chains with aromatic and electronegative features are found to be the most important descriptors in predicting Plasmodium kinases inhibitory activity. Furthermore, a 3D-QSAR study using CoMFA and CoMSIA was carried out to investigate the molecular property determinants. The CoMFA model suggested that the favorable substitution of steric groups with electronegative properties at ring A. Furthermore, CoMSIA model indicated the possible role of H bond donor groups at 5 and 6 positions of ring A whereas H bond acceptors at 7 and 8 positions of ring A in enhancing the biological activities. The developed QSAR models can be used to discover new effective antimalarial leads for further development as antimalarial...
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Posted by admin on Oct 1, 2014 in |
Herbal fungicides are gaining great interest because of their cost-effective and eco-friendly attributes. If this antifungal potency resides in weeds, it will be a great advantage because of their large population and to effectively develop a novel drug from weeds being considered as waste material. The present study aims to assess the anti-aspergillus activity of a common weed Lantana camara. The crude extract of leaves was obtained using polar and non- polar solvents and tested against Aspergillus niger ATCC 16888. Results reveal, the aqueous extract showed maximum growth inhibition of 14 ± 0.142 mm zone at 30 mg/ml, and it was 37 ± 0.124 mm for the standard antifungal agent voriconazole at 30 mg/disc. Further, the minimum inhibitory concentration of the extract was calculated as 18 mg/ml. Experiments on the mode of action suggested that the extract lyse the cells and alter the membrane integrity by depleting the ergosterol content, which avoids the...
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Posted by admin on Oct 1, 2014 in |
Hypertension is one of the most important public health problems globally. If the blood pressure is effectively controlled, many of the disastrous complications of hypertension such as myocardial infarction, stroke, kidney failure, heart failure, and death can be prevented or delayed. Patients usually attend the family physicians first for any illness they are suffering, including hypertension. Hence, family physicians who are primary care providers play a major role in the management of hypertension. A survey based on a validated questionnaire was conducted among primary care physicians of Puducherry to assess their current knowledge regarding investigations and pharmacotherapy of hypertension and associated comorbid diseases. Eighty, one primary care physicians, responded. Though, more than 53% of primary care physician favored fundus examination, lipid profile and electrocardiogram as essential investigations, urine for microalbuminuria was favored only by 11.11% of physicians. It is noteworthy that more than 82% of primary care physicians are aware that methyldopa should be the drug of choice for pregnancy-induced hypertension. However, more than 76% of primary care physicians...
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