Posted by admin on Aug 1, 2014 in |
Background: With the dramatic advances in the medical science, treatment of many cancers is not just palliative, but rather curative in today’s world. The dosage regimen and the method of administration can greatly affect their efficacy and toxicity. Aims and Objects: To study the patterns of adverse drug reaction to cancer chemotherapy and to assess the causality, severity and predictability of those adverse reactions. Materials and Methods: The study was conducted in the department of Radiotherapy for a period of 6 months. It is a prospective study and included all in-patients & outpatients with adverse effects during the study period. The data was collected using ADR (adverse drug reaction) form designed by CDSCO (Centre for Drug Standard Control Organization) and statistical analysis was done using SPSS 20. Results: A total of 224 adverse reactions were noted in 178 patients with M:F ratio of 1:1.5. 54.5 % of the reactions were observed in age group of 40-60 years. The most common single drug causing reaction is cisplatin and regimen is...
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Posted by admin on Aug 1, 2014 in |
Aerva javanica belonging to family (Amaranthaceae) roots and flowers are reported to possess medicinal properties against rheumatism and kidney problems. The present work is to evaluate the nephroprotective effect of Aerva javanica by cisplatin induced renal toxicity in adult male albino rats of Wistar strain. The effect ofalcoholic extract and aqueous extract were evaluated at 200 mg/kg and 400 mg/kg, in rats against nephrotoxicity induced by administration of cisplatin through intra peritoneal route. Various serum parameters were studied along with histopathological examination of kidneys in each treatment group. Both the extracts were compared to the ursolic acid at the dose of 150 mg/kg as a standard drug. Alcoholic extract was foundto have significant nephroprotective activity. The levels of urea, creatinine, albumin and total protein in the serum were normalized after treatment with alcoholic extract at both the doses. The alcoholic extract at the dose of 400 mg/kg shows similar result as compared to the reference standard ursolic acid. The alcoholic extract of A. javanica possesses marked nephroprotective activity and...
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Posted by admin on Aug 1, 2014 in |
The in vitro antimicrobial activity of acetone, methanol and water extracts of leaf, stem bark and fruit of Elaeocarpus serratus L. (Elaeocarpaceae) was examined against four bacterial species (Shigella sonnei, Salmonella typhi, Staphylococcus aureus and Klebsiella pneumoniae) and a fungal species (Candida albicans) using the agar well diffusion method. Phytochemical screening was carried out for phenols, flavonoids and tannins. Results showed that the plant extracts exhibited a dose-dependent inhibition of microorganisms. The acetone and methanol extracts of leaf and stem bark of E. serratus displayed maximum antibacterial activity against all the bacterial species studied. The plant extracts also displayed high antifungal activity against Candida albicans especially, the acetone extract was found to be more active antifungal. Generally, the lower concentrations of the extracts were susceptible to the fungal pathogen. E. serratus extracts contained phenols, flavonoids and tannins at varying levels. The ability of the crude extracts of the test plant to inhibit the growth of bacteria and fungi is an indication of its broad spectrum antimicrobial potential which may...
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Posted by admin on Aug 1, 2014 in |
The investigation was carried out to determine the possible bioactive compounds marine macro algae Padina australis using methanol extract. The GC-MS analysis of methanol extract was performed using perkin Elmer GC clarus. Six compounds were identified from Padina australis showed highest peak area Pentadecanoic acid 14-methyl ester [100%] followed by 1, 2 Benzenedi carboxylic acid, butyl octyl ester [91.5%], Octadecenoic acid, methyl ester [82.3%] 10-Octadecenoic acid, methyl ester [78.6%] and Oleic acid [56.4%]. The compound 9- Octadecenoic acid [Z]; 2-hydroxy-1 [hydroxyl methyl ester] showed the lowest peak area of...
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Posted by admin on Aug 1, 2014 in |
Objective: To investigate the neem active constituent nimbolide for the evidence of acute toxicity and its protective effects against carbon tetrachloride (CCl4) induced liver toxicity in rats. Materials and Methods: Group allotment in hepatoprotective activity study included vehicle, CCl4 (1ml/kg), Silymarin (100 µg/kg/day) + CCl4 and graded doses of nimbolide (100 and 200µg/ kg/ day) + CCl4. On 9th day, blood was obtained for determination of biochemical parameters and liver tissue for pathological examination. Results: There were no toxicological effects as evidenced by signs of mortality, behavior, diet consumption and tissue weights, however, some hematological parameters showed alterations in their value at higher dose level. The degree of protection was measured by using various biochemical parameters like total protein, albumin, BUN, AST, ALT and ALP levels. Nimbolide showed dose dependent hepatoprotective in nature which was further substantiated by marked decrease in incidence of hepatocellular necrosis on histopathological and transmission electron microscopic analysis. Conclusion: This study suggests nimbolide possess hepatoprotective effect against CCl4 induced liver damage in rats with efficiency...
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