Posted by admin on Jul 1, 2014 in |
The purpose of this study was to evaluate the quality of the commonly prescribed imported and locally manufactured antipsychotic drugs (chlorpromazine and thioridazine tablets) that are marketed in drug retail outlets in Ethiopia. Four different sources of Chlorpromazine and two thioridazine tablets were assessed in this investigation. The quality of the samples was examined in seven aspects: percent label amount (assay), weight variation, hardness, percent friability, purity, disintegration time and dissolution rate according to British pharmacopeia (2000) specification. The identity of the tablets was confirmed using FT-IR spectrophotometer. All chlorpromazine and thioridazine samples showed acceptable weight variation as none had percent deviation in weight greater than 5% as stipulated by BP (2000). The mean disintegration times of the products ranged from 4.50 ±0.84 (for chlorpromazine from Cyprus) to more than 60 min (for chlorpromazine Korea). All the tested samples showed active ingredient content with in the acceptable range (from 92.5%-107.5%). Thioridazine 25 mg showed high drug content (107±0.5) and the lowest amount was recorded for chlorpromazine from Cyprus (93.0...
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Posted by admin on Jul 1, 2014 in |
Among various novel drug delivery systems fast dissolving tablets have attracted great attention in recent years due to their ability to release the drug content gradually. Therefore the demand for this dosage form has been increased since last few years especially in patients with swallowing difficulties as this dosage form provides advantage of being swallowed without water. The objective of this research study was to prepare and evaluate fast dissolving tablet of Fexofenadine for acting as a suitable approach to the treatment of allergy together with improved efficacy and reduced dosing frequency. The tablets were prepared by direct compression technique after incorporating superdisintegrants (Ac-di-sol, Sodium starch Glycolate and Crospovidone) in concentrations (1-4%). For preliminary studies twelve (F1-F12) formulations were prepared. Optimization technique was employed to predict the best formulation of all combinations prepared. Pre and Post compression characterization was done on tablets. Then co processed superdisintegrants were used for formulation of tablets showing superior properties. In investigation 32 full factorial design was employed to investigate the combined effect of...
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Posted by admin on Jul 1, 2014 in |
Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersions based on the concept that the drug is dispersed in an inert water-soluble carrier at solid state. Several water soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. Thus the solid dispersion technique can be successfully used for the improvement of dissolution of Fenofibrate. Various solvents, carrier materials, diluents, disintegrating agents, lubricants has been used for the preparation of solid dispersion of fenofibrate. Over the years, a variety of solubilization techniques have been studied and widely used, by many estimates up to 40 per cent of new chemical entities discovered by the pharmaceutical industry today are poorly soluble or lipophilic compounds. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The various techniques...
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Posted by admin on Jul 1, 2014 in |
Objective: To isolate and analyze the chemical components in crude methanolic extract from the South Indian medicinal plant of Kyllinga triceps by gas chromatography-mass spectrometry (GC-MS). Methods: Preliminary phytochemical screening of the extract was carried out according to the standard method described by Brindha et al. The shade dried powder was extracted with methanol by using soxhlet extractor. The GC-MS analysis of methanolic extract of Kyllinga tricepswas performed using a GC–MS equipment Thermo GC-TRACE ultra ver., 5.0, Thermo MS DSQ II. Experimental conditions of GC-MS system were as follows: TR 5-MS capillary standard non-polar column, dimension: 30 Mts, ID: 0.25 mm, Film: 0.25 µm was used and flow rate of mobile phase (carrier gas: He) was set at 1.0 ml/min. Crude samples which dissolved in methanol were run fully at a range of 50-650 m/z and the results were compared by using Wiley Spectral library search programme. Results: The phytochemical analysis of the extract revealed the presence of steroids, alkaloids, sugar, phenolic compounds, flavonoids, saponins, tannins and amino acids.The...
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Posted by admin on Jul 1, 2014 in |
Antifertility effect of ethanol extract of leaf of Eugenia singampattiana was observed in male albino rats. The relative weight of the testes and epididymis were decreased. The epididymal sperm count, motility and sperm abnormality were reduced significantly in treated rats. There was an increase in serum urea, creatinine and the activity of liver marker enzyme (SGOT) levels of drug treated rats. The results of the hormonal assay showed increased serum levels of FSH and estrogen but decreased levels of LH and testosterone when compared to control. The results of the present study concluded that, ethanol extract of leaf of E. singampattiana inhibited sperm concentration, motility and testosterone which might result in a male...
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