Posted by admin on Sep 1, 2014 in |
Overproduction of free radicals can cause oxidative damage to biomolecules (e.g., lipids, proteins, DNA), eventually leading to many chronic diseases, such as atherosclerosis, cancer, diabetes, aging, and other degenerative diseases in humans. Plants may contain a wide variety of free radical scavenging molecules, such as phenolic compounds, nitrogen compounds, vitamins, terpenoids, and some other endogenous metabolites, which are rich in antioxidant activity. In the present study in-vitro antioxidant potential of various fractions of Hibiscus rosa sinensis petal (HRS) ethanolic extract was investigated. Fractions prepared from crude ethanolic extract of HRS were concentrated and used for various in-vitro assays. Ethyl acetate fraction of HRS (EHRS) had a very high content of total phenolics and flavonoids. DPPH radical scavenging activity (IC50-9µg/ml) of EHRS was comparable with standard Quercetin. Superoxide, ABTS, and hydroxyl radical scavenging activities of EHRS were also found higher than other fractions. The total antioxidant activity and reducing power were also high in EHRS. So the study suggests that EHRS may be a potential source of bioactive substances with...
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Posted by admin on Sep 1, 2014 in |
ABSTRACT: Celastrus paniculatus is a known herb used in alternative system of medicines since ancient times. Traditionally seed oil of Celastrus paniculatus has been in various medicinal remedies to cure neuronal disorders, asthma, cough, etc. The constituents found in Celastrus paniculatus reportedly are sesquiterpenoids, triglycerides, triterpenoids. A high-performance thin layer chromatography, which is considered as a sensitive method for accurate quantification method for analysis of compounds. The instrument CAMAG Linomat 5 lamp was used, and the wavelength was 254...
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Posted by admin on Sep 1, 2014 in |
Local traditional healers in the Great Lakes Region used to administer Hypoestes triflora (Roem) leaf decoctions to treat patients with anemia and liver diseases, and also to boost immunity in HIV patients. This study was designed to evaluate, in guinea-pigs, the antianemic and hepatoprotective potentials of this plant. Anemia was induced with phenylhydrazine hydrochloride and hepatotoxicity with paracetamol. Animals were divided into normal (N), control (C), test (T), and reference (R) groups. T group included ill-induced animals treated with H. triflora aqueous extracts and R ill-induced animals treated with an Iron solution for anemic animals or silymarin for hepatitis animals. Dosing was made as 1-day single dose or 7-days repeated dose. In anemic animals, the production rate of RBC was significantly (p<0.001) higher in the T group as compared to the C group. In paracetamol-induced hepatitis animals, the plant extract exhibited about 80-90% protective effect in T group as compared to the C group. The effects were comparable to or higher than R responses. H. triflora leaf extracts have...
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Posted by admin on Sep 1, 2014 in |
Mycobacterium leprae, the causative agent of the disease, leprosy develops resistance against most of the drugs, so novel drug targets are required to design new drugs. Present work is aimed at understanding the inhibition of enoyl-acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the receptor proteins used in drug discovery for screening anti-leprosy agents by virtually designed sulfone class of compounds. The crystal structure of the inhibited M. leprae InhA complex (2NTV) provides the details of protein-ligand interactions. The virtually designed series of compounds having sulfone moiety have docked well in the active site region of the protein. The prediction of ADME properties was also performed by Qikprop software. Mycobacterium leprae, the causative agent of the disease, leprosy develops resistance against most of the drugs, so novel drug targets are required to design new drugs. Present work is aimed at understanding the inhibition of enoyl-acyl carrier protein reductase (Enoyl-ACP reductase), which is one of the receptor proteins used in drug discovery for screening anti-leprosy agents by virtually...
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Posted by admin on Sep 1, 2014 in |
Kaempferia galanga (Family: Zingiberaceae) has immense importance in the traditional health care system as a carminative, cholera, anti-inflammatory, abdominal pain, dyspepsia, and stomachic as well as in the diseases of coughs, pectoral affections, and stoppage of the nasal blocks. Grewia paniculata (Family: Malvaceae) has been used in traditional medicine for the treatment of indigestion, eczema, itch, small-pox, typhoid fever, dysentery and syphilitic ulceration of the mouth. Leaves of this plant used along with turmeric and shell of snail for the treatment of jaundice. This study was aimed to investigate the antidiarrhoeal activity of the acetonic extract of Kaempferia galanga and ethanolic extract of Grewia paniculata. The acetone extract of rhizome (ACR), as well acetone extract of the leaf (ACL), ethanol extract of bark (EEB) and ethanol extract of the leaf (EEL) were subjected to antidiarrhoeal activity test. The antidiarrhoeal activity was performed by castor oil-induced diarrhea in mice. In this study, both plant extracts exhibited significant inhibition (p < 0.05-0.001) and a dose-dependent decrease in the total number of...
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