Posted by admin on Jul 1, 2014 in |
Four wild plant species (Chrysthanthemum cornarium, Capparis spinosa, Carthamus lanatus, Haplophyllum tuberculatum) were investigated for their antioxidant activity, phenolic and flavonoid contents of their methanolic extracts. The antioxidant activity of the extracts was assessed their free radical scavenging properties using DPPH. Total phenolics and total flavonoids were detected by spectrophotometric and HPLC methods. The HPLC analysis compared with 14 reference standard phenolic compounds, results confirmed that gallic acid , chlorogenic acid, caffeic acid, 2,5- dihydroxy benzoic acid, and catechin were detected in the four methanolic plant extracts. HPLC chromatograms of the plant extracts showed that there was noticeable valuation in the distribution of phenolic compounds in the four studied species. Six bacterial strains were used in this study, three Gram-positive and three Gram-negative. Concerning with antimicrobial activity, results showed that plant extracts of the studied species are a great source of phenolic compounds and represent the highest antibacterial activity against Gram-positive and negative bacteria. Results revealed that extracts represents the highest antibacterial activity against Gram-positive and negative bacteria and...
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Posted by admin on Jul 1, 2014 in |
Many infectious diseases are known to be treated with herbal remedies throughout the history of mankind. Even today, plant materials continue to play a major role in primary health care as therapeutic remedies in many developing countries. Traditional system of medicine is found to have utilities as many accounts. Due to population rise adequate supply of drug and high cost of treatment in side effect along with drug resistance has been encountered in synthetic drugs, which has lead to an elevated emphasis for the use of plants to treat human diseases. A major part of the total population in developing countries still uses traditional folk medicine for different diseases obtained from plant resources. Due to the indiscriminate use of antimicrobial drugs, the emergency of human pathogenic microorganism’s resistance has been increased. According to WHO, as many as 80% of world’s population living in rural areas rely on herbal traditional medicines as their primary healthcare, the properties and uses of medicinal plants are interestingly growing. Thus, due to prevalence of...
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Posted by admin on Jul 1, 2014 in |
Increased production of reactive oxygen species plays important role in pathogenesis of chronic fluoride toxicity resulting from prolonged exposure to fluoride. Oral (NaF) fluoride administration to rats at 20 mg/kg b.w./day for 30 days resulted in elevation in MDA, free amino acid N2, NO level and decreased activities of SOD, GPx, CAT, GR and reduced non enzymatic antioxidant like GSH. Significant alteration in protein and nucleic acid metabolism in discrete brain regions was observed associated with altered activities of proteolytic and transaminase enzymes in treated animals. Neanotis wightiana is traditionally used by local people of Tripura for brain and liver disorders. 3α-hydroxy olean-12-en-27-oic acid isolated from the plant was administered to rats at a dose of 5 mg/kg b.w./day orally for the last 14 days of fluoride exposure in order to elucidate the antioxidative role of this triterpenoid compound in brain protein and nucleic acid metabolism during toxic insult. The present study indicates that the compound appreciably prevented NaF-induced changes in above mentioned parameters in rat brain by antagonizing...
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Posted by admin on Jul 1, 2014 in |
Coronary artery disease (CAD) is the major cause of mortality and morbidity worldwide. The incident of CAD is rising and they are predicted to be the biggest causes of death by 2020 in India. Therefore, the aim of the present study was to assess the association of oxidative stress, antioxidant enzyme and lipid status parameters in CAD patients and to compare the results age- sex matched healthy control in our community. Three hundred participants were enrolled for the present study, with their ages ranging from 40 to 60 years from Era’s Lucknow Medical College & Hospital, Lucknow. Out of which one hundred fifty were clinically new diagnosed case of coronary artery disease like angina pectoris and Myocardial infarction (MI), remaining one hundred fifty were healthy controls. These participants were investigated for serum lipid profile i.e. total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL). High density lipoprotein (HDL) along with blood levels of TBARS and some antioxidant enzyme namely Catalase (CAT), Superoxide dismutase (SOD),...
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Posted by admin on Jul 1, 2014 in |
The purpose of this study was to evaluate the quality of the commonly prescribed imported and locally manufactured antipsychotic drugs (chlorpromazine and thioridazine tablets) that are marketed in drug retail outlets in Ethiopia. Four different sources of Chlorpromazine and two thioridazine tablets were assessed in this investigation. The quality of the samples was examined in seven aspects: percent label amount (assay), weight variation, hardness, percent friability, purity, disintegration time and dissolution rate according to British pharmacopeia (2000) specification. The identity of the tablets was confirmed using FT-IR spectrophotometer. All chlorpromazine and thioridazine samples showed acceptable weight variation as none had percent deviation in weight greater than 5% as stipulated by BP (2000). The mean disintegration times of the products ranged from 4.50 ±0.84 (for chlorpromazine from Cyprus) to more than 60 min (for chlorpromazine Korea). All the tested samples showed active ingredient content with in the acceptable range (from 92.5%-107.5%). Thioridazine 25 mg showed high drug content (107±0.5) and the lowest amount was recorded for chlorpromazine from Cyprus (93.0...
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