Posted by admin on Jun 1, 2014 in |
The chloroform extracts of S. asoca bark were studied for the wound healing potential. The wound healing activity of S. asoca bark by excision, incision and dead space wound models in albino Wistar rats and antioxidant profile of this bark extract were also studied as there is an increase in the levels of free radicals during the damage of tissue. The parameters like wound contraction, period of epithelialisation, tensile strength and hydroxyproline content were evaluated in three wound models, namely; excision, incision and dead space wound models. Besides, their influences on oxidative stress in three wound models were also estimated. The results obtained were compared with standard drug nitrofurazone and control in terms of wound contraction, period of epithelialisation, tensile strength and hydroxyproline content. The chloroform extract of S. asoca bark showed significant results in all models when compared to standard and control. A subservient study made on the levels of superoxide-dismutase, catalase, glutathione, vitamin C and lipid peroxidation are recorded and a significant increase in the levels of...
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Posted by admin on Jun 1, 2014 in |
The aim of this study was to develop and optimize nano-liposomally entrapped ketotifen fumarate (KTF) loaded dry powder inhalation (DPI) formulation using response surface methodology (RSM). Based on the 33 full factorial design (33FFD), the mass ratio of KTF solution to soybean phosphatidylcholine (SPC94), KTF/ SPC94 to 0.5 M lactose solution that after lyophilization produce lyophilized liposomal powder (LLP) and LLP to coarse lactose carrier (CLC) were selected as independent variables with KTF liposomal encapsulation efficiency (%EE), liposomes particle size (PS) and fine particle fraction (%FPF) as dependent variables. The aerosolized liposomal dry powder was prepared utilizing vesicular phospholipid gel technique followed by lyophilization after incorporating it into lactose solution as a cryoprotectant. A full and reduced second-order polynomial models were developed for each response using multiple linear regression analysis. Applying a desirability function method, the optimum parameters were: KTF: SPC94 of 0.045, KTF/ SPC94: 0.5 M lactose of 0.389 and LLP: CLC of 0.080. At this optimum point, the %EE, PS and %FPF were found to be 52.68%,...
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Posted by admin on Jun 1, 2014 in |
Objective: This study was designed for Screening of anti-inflammatory and anti-analgesic activity of ethanolic extract of Convolvulus pluricaulis Choisy in various animal experimental models. Material and Methods: Ethanolic extract of Convolvulus pluricaulis Choisy evaluated for anti-inflammatory activity in Carrageenan-induced paw edema, Cotton pellet-induced granuloma model. The anti-analgesic activity was evaluated by Hot Plate Method and Tail-Flick Assay. Result: Administration of the ethanolic extract of Convolvulus pluricaulis Choisy at dose of 800 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The analgesic activity was determined on Wistar albino rats by hot plate method, tail flick assay using Morphine sulphate as standard drug at a dose of 5 mg/kg of body weight and the results were expressed as mean increase in latency after drug administration ± SEM. Conclusion: This study shows that ethanolic extract of Convolvulus pluricaulis Choisy has significant anti-inflammatory and anti-analgesic...
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Posted by admin on Jun 1, 2014 in |
A series of new 1H-benzo[d]imidazole derivatives of 3, 4-substituted triazole. 3-(1H-Benzo[d]imidazol-2-ylsulfanyl) methyl-4-[phenyloxy(phenylacetamido)]-5-mercapto-1,2,4-triazole and related aryloxy compounds were synthesised, analysed and characterised by FTIR, 1HNMR and elemental analysis. These compounds were screened for antibacterial and antifungal activity. The antibacterial activities were compared against chlorophenicol and antifungal activity with mycostalin. Some triazole derivatives showed a little antibacterial but appreciable antifungal...
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Posted by admin on Jun 1, 2014 in |
Diabetes mellitus is a metabolic syndrome involving severe insulin dysfunction in conjugation with gross abnormalities in glucose homeostasis and lipid metabolism, which has been affecting several millions of population all over the world. Despite the introduction of hypoglycemic agents from natural as well as synthetic sources, diabetes and its secondary complications continue to be a major health problem for the medical fraternity. Sesbania grandiflora L. Pers. is an Indian medicinal plant which belongs to family Leguminosae possesses a wide array of beneficial and pharmacological properties. In the present study an attempt has been made to evaluate the antidiabetic and antioxidant nature of Sesbania grandiflora leaves. Diabetes was induced by single intraperitoneal injection of streptozotocin (45mg/Kg b.wt). Diabetic rats orally treated with leaves extract ( 300 mg/kg b.w/day) for 30 days resulted in significant (p<0.05) decrease in the levels of blood glucose, glycosylated hemoglobin, blood urea, serum uric acid, serum creatinine and diminished activities of pathophysiological enzymes such as aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP). The...
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