Posted by admin on Apr 1, 2014 in |
Parthenium hysterophorus L., compositae, also known as congress weed, carrot weed, star weed, reaching a height of 2 m in weeks of germination, is believed to have entered India accidentally in the mid 1950’s and is now available abundantly all over the India. Leaves are traditionally used in the treatment of asthma and allergy, leavas of the plant were extracted successively using aqueous and ethanol solvents to obtain the respective extracts. In the present study, we have investigated the role of aqueous and ethanol extracts of Parthenium hysterophorus against milk-induced leukocytosis and eosinophilia in albino mice. The results of the study revealed that pretreatment with both the extracts caused significant reduction in the total leukocyte and eosinophil counts in animals in dose-dependent manner. From these results, it can be concluded that the plant Parthenium hysterophorus is having antieosinophilic...
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Posted by admin on Apr 1, 2014 in |
The therapeutic use of herbal medicine has gained considerable momentum in the world during the past decade. Hence, Quality control standards for various medicinal plants used in indigenous systems of medicine are becoming more necessary. Adulteration and misidentification of medicinal plants can cause serious health problems to consumers and pose legal problems for pharmaceutical firms. So, the aim of this investigation was to establish a simple and efficient protocol to determine possible drug adulteration by use of similar plants. Powder microscopy can help the correct identification and establish standardization of plant drugs. The present study has revealed an easy way to identify Alpinia calcarata and Alpinia galanga microscopically and thus it can also be employed to detect the degree of adulteration in powdered raw medicinal plant materials as well. Likewise, microscopical detection is easy, reliable and cost effective tool for detection of adulteration in medicinal plants.Alpinia calcarata Rosc. and Alpinia galanga Linn. of Zingiberaceae popularly known also as Lesser galangal and greater galangal, have a widespread occurrence in India,...
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Posted by admin on Apr 1, 2014 in |
The present work was designed to formulate floating tablet of Metoprolol Succinate with synthetic superdisintegrant as swelling agent. Various formulations of Metoprolol Succinate were prepared by direct compression method using the different concentrations of superdisintegrant ranging from 10% to 15%. The selected batches were evaluated for various parameter like weight variation, thickness, diameter, friability, floating lag time, duration of floating, water uptake, content uniformity, in-vitro drug release and in-vitro drug release kinetics. Formulations with Crosspovidone had showed better results than the Kyron T-314. The data obtained from the in-vitro dissolution studies of optimized batch F5 was fitted in different models viz. zero order, first order, Korsemeyer-Peppas model, Higuchi model and Hixon-Crowell model. Drug release mechanism was found to be First order from optimized formulation. Further for getting the type of release mechanism the data was fitted as per the Korsemeyer-Peppas equation. The exponent value n was found in between 0.45 to 0.89. It indicates that the release of Metoprolol Succinate from developed floating tablets followed non-Fickian transport...
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Posted by admin on Mar 1, 2014 in |
The aim of the present study was to prepare solid lipid nanoparticles (SLNs) for the topical delivery. Tristearin was used as solid lipid with soya lecithin by using surfactant, Poloxamer 188 (1%) and Tween 80 (0.5%). Solid lipid nanoparticles (SLN) loaded with Flucanazole were prepared by solvent diffusion- emulsification method. The properties of the SLNs such as particle size, zeta potential (ZP), Polydispersity index (PI) and drug % entrapment efficiency (% EE) were investigated. The morphology of SLNs was observed by transmission electron microscopy (TEM) and Scanning electron microscopy (SEM). The drug release behavior was studied by in vitro method using franz diffusion cell with dialysis membrane. The results show the formulation F2 had smallest particle size of 122±3.42 nm with Zeta potential -24.03±1.84 and Polydispersity index 0.668±3.21. The % Entrapment efficiency of formulation F2 was found to be 76.53±0.24. The average particles sizes of the nanoparticles were found to increase on storage, which may be due to aggregation of particles. This effect was encountered lower in the case...
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Posted by admin on Mar 1, 2014 in |
Gum Arabic (GA) is a water-soluble polysaccharide, obtained from stems of Acacia senegal trees as gummy exudates. It is a beneficial adjunct to the low-protein diet for chronic renal failure patient because it reduces serum urea nitrogen level. It is also have a good protective activity against CCl4 and acetaminophen-induced hepatotoxicity in rats but it failed protect kidney from gentamicin-induced nephrotoxicity. The goal of current study was to investigate the cardioprotective of gum Arabic aqueous extract against Cardiotoxicity induced by doxorubicin in rats. Wistar albino rats were divided into four groups, 5 rats in each group: Group A (as a control), group B (Doxorubicin (DOX)-only treated rats, 15mg/Kg, IP as a single loading dose), group C (GA 10g/Kg body weight, orally for 4weeks prior DOX treatment) and Group D (GA-only treated group). Histopathological examination and serum biomarker enzymes like Creatine Kinase (CK), Lactate Dehydrogenase (LDH), serum aspartate transaminase (AST) and serum alanine transaminase (ALT) levels were monitored at the end of study to evaluate cardiotoxicity. The study showed that...
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