Posted by admin on May 31, 2025 in |
Momordica cymbalaria, an underexplored vegetable crop native to India, holds significant therapeutic potential due to its traditional antidiabetic use. This study explores its phylogenetic characterization, protein structure modelling, and phytochemical profiling, emphasizing its role in diabetes management. The 5.8S rRNA internal transcribed spacer sequence was retrieved from NCBI and analysed using BLAST, identifying 17 related species and insights into its evolutionary positioning. Phylogenetic analysis revealed close relationships with Momordi cafoetida and distant similarity to Momordica balsamina. Protein structure prediction using SWISS-MODEL and PyMOL identified key structural features and active sites. Three open reading frames (ORFs) were identified, potentially encoding proteins involved in diabetes-related pathways. Phytochemical analysis using Dr. Duke’s and IMPPAT databases highlighted bioactive compounds such as beta-sitosterol, ergosterol, and alpha-eleostearic acid (ESA), a potent antidiabetic compound. ESA modulates the adipose deposition pathway and improves glucose regulation by interacting with proteins like peroxisome proliferator-activated receptor gamma (PPARG) and ribosomal protein L19. In-silico analysis demonstrated ESA’s ability to enhance GLUT-4 and beta-glucokinase activity, facilitating glucose uptake and improving metabolic efficiency....
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Posted by admin on May 31, 2025 in |
The most widely used cationic dye, methyl violet (MV), has significant carcinogenic potential. The textile, cosmetic, printing, pharmaceutical, and food processing sectors all make extensive use of artificial dyes. They are typically referred to as xenobiotics because of their strong resistance to biodegradation. Microbes are beneficial because of their rapid growth and ability to break down and mineralise dyes. Methyl violet-degrading Enterobacter sp. was isolated from the Ganges River. It degrades up to 180 ppm of methyl violet in 24 hours when shaken at 25°C – 45ºC and pH 1 -12; optimum degradation occurs at 40 ppm in 24 hours at pH 7.0. The effects of temperature, initial pH, and dye concentration were investigated. The capacity of bacteria to degrade was demonstrated by experimental results. The deterioration of methyl violet was validated by UV-Vis spectroscopy, SEM, and FTIR examination of samples both before and after dye breakdown in culture...
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Posted by admin on May 31, 2025 in |
The fossa of Rosenmuller is the most common site of NPC. It arises from the lining mucosa of the nasopharynx. Around one-fifth of NPC patients presented with cranial nerve palsy. The tumor can penetrate the skull and surrounding cranial nerves because fossa of Rosenmuller is situated next to the foramen lacerum. A 57-year-old male patient arrived at the medical college and Hospital, Kolkata ENT opd complaining of headache, fullness in his ears, a mass on his left neck, and nosebleeds. The patient’s vision was normal. Following a comprehensive physical examination, radiography, histology, and history taking following examinations, the patient was identified as having House Brackmann III facial nerve palsy at the level of the mastoid segment and WHO 3 ECOG I T4N2M0 stage III NPC. A regimen of paclitaxel-cisplatin for six rounds was administered. In conclusion, NPC has the unusual potential to result in facial nerve...
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Posted by admin on May 31, 2025 in |
Background: Managing Parkinson’s disease (PD) requires a multimodal strategy, with pharmaceutical therapies being an essential component. This study’s goal was to look into how antiparkinsonian drug prescriptions are given to PD patients at a tertiary care facility. Methods: Five hundred Parkinson’s disease (PD) patients who visited the Department of Neurology at Mallige Hospital in Bengaluru, India, participated in an observational, cross-sectional study. Patients’ medication histories were used to stratify them into three different groups: Group 1 (patients on medications at initial visit), Group 2 (patients who discontinued medications), and Group 3 (Drug-naïve patients). Results: The average age of PD onset was 51.5 ± 11.6 years. The patients were divided into three groups at the first visit: 76.4% (n=382) were on medications for PD (Group 1), 12.6% (n=63) had previously taken medications but discontinued (Group 2), and 11% (n=55) were drug-naïve (Group 3). Overall, levodopa was prescribed in 90.33%, trihexyphenidyl in 34.38%, in group 1, 48.7% were on monotherapy, with levodopa being the most commonly used agent (42.9%), followed by...
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Posted by admin on May 31, 2025 in |
Benign subglottic stenosis is a life-threatening condition. It commonly corresponds to postintubation injuries associated with prolonged endotracheal intubation. The surgical correction of a subglottic stenosis presents anaesthetic challenges which are unique to airway anatomy, physiology and shared surgical airway. Management of these patients involves an integrated multidisciplinary approach and close-loop communication with the surgical team regarding tracheal excision and re-anastomosis, proper intubation and extubation strategies and, adequate postoperative care. Here, we present a case of successful management of a nineteen-year-old girl with post-intubation tracheal stenosis who presented with stridor and difficulty breathing after a history of being intubated for 6 days. She was refractory to conservative management and hence was posted for tracheal resection and anastomosis which is the gold standard therapy. This case report throws light on the challenges faced by an anaesthesiologist in the perioperative management of the...
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