Posted by admin on Jul 31, 2026 in |
Ellagic acid, a naturally occurring polyphenolic compound is found in various fruits and vegetables and has attracted considerable attention due to its broad spectrum of biological and pharmacological properties. Several key aspects of ellagic acid, including its antioxidant activity, anti-cancer properties, anti-inflammatory effects, protective role in cardiovascular health, as well as its antibacterial and antiviral activities, were highlighted in prior research. The proposed UV method, found to be simple and novel. The developed method aligns with the concept of “green” solvents, aiming to minimize the environmental damage typically caused by solvent use in chemical production. Ethanol was chosen as the solvent Instead of all other alternatives. The absorbance of ellagic acid was measured in the UV range, and a λmax of 254 nm was identified. Recovery studies and statistical validation further supported the findings of the study. The drug follows linearity in the concentration range of 2–10µg/ml. The low values of % RSD are indicative of the accuracy and reproducibility of the method. Precision was assessed through repeatability tests....
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Posted by admin on Jul 31, 2026 in |
Objectives: Systemic antifungal therapy is widely used for dermatophytosis, but concerns regarding biochemical safety and adverse effects remain clinically relevant. This study aimed to compare the biochemical safety profile of oral itraconazole and terbinafine in patients with superficial dermatophytosis. Methods: In this prospective comparative clinical study, 180 adult patients with potassium hydroxide-confirmed superficial dermatophytosis were allocated into two groups (n=90 each). Group A received oral itraconazole 100 mg twice daily, and Group B received oral terbinafine 250 mg once daily for six weeks, and both groups received topical clotrimazole. Biochemical parameters, including serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum creatinine, and random blood sugar, were assessed at baseline and at six weeks. Adverse events were recorded. Data were expressed as mean ± standard error (SE), and statistical comparisons were performed using Student’s t-test and chi-square test. Results: No statistically significant changes in hepatic enzymes, renal function, or metabolic parameters were observed within or between groups after six weeks of therapy (p>0.05). Adverse events were mild...
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Posted by admin on Jul 31, 2026 in |
In recent years, the popularity of silymarin, lauded for their nutritional and health benefits, has soared. Among these products, silymarin and its main constituent, silibinin, have a hepatoprotective effect due to their antioxidant activity as well as a membrane-stabilizing property that inhibits or stops the process of lipid peroxidation. Additionally, they may help avoid gallbladder and spleen diseases. It’s anti-inflammatory, anti-cancer, anti-oxidant, and anti-diabetic qualities are well known. However, challenges related to standardization and quality control persist in the realm of herbal medicines, including silymarin supplements. This study aimed to evaluate the quality of widely used silymarin tablets from three different commercial brands, employing established pharmacopeia standards. Parameters assessed included post-formulation characteristics (diameter, thickness, hardness, friability, weight variation, and disintegration) and quantification of silibinin using high-performance liquid chromatography (HPLC). The findings confirmed that the investigated silymarin tablets adhered to specified post-formulation parameters, reinforcing their reliability as dietary supplements. The silibinin content determined by HPLC was found to be 40.60, 40.39 mg and 60.17 mg per tablet...
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Posted by admin on Jul 31, 2026 in |
This study evaluated and compared the efficacy and safety of sitagliptin and gliclazide in patients with uncomplicated type 2 diabetes mellitus. A total of 291 patients were assigned to two treatment groups receiving either sitagliptin or gliclazide. Glycemic parameters, including fasting blood glucose, postprandial blood glucose, and glycated hemoglobin levels, were assessed over a period of six months. Adverse effects, particularly episodes of hypoglycemia, were also monitored to evaluate safety. Both treatment groups showed significant improvement in glycemic control over time. However, gliclazide demonstrated a more consistent and greater reduction in fasting and postprandial blood glucose levels. A statistically significant reduction in glycated hemoglobin was observed in the gliclazide group, whereas the reduction in the sitagliptin group did not reach statistical significance. In terms of safety, gliclazide was associated with a higher incidence of hypoglycemic episodes. Sitagliptin, although producing relatively modest improvements in glycemic parameters, exhibited a more favorable safety profile with fewer hypoglycemic events. In conclusion, gliclazide provides superior glycemic control in patients with uncomplicated type 2 diabetes...
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Posted by admin on Jul 31, 2026 in |
Nail plate disorders account for 10% of all dermatological disorders having an impact on 20-25% of population worldwide. Nail bed infections are difficult to treat due to shorter nail residence time of topically applied formulation and unavailability of novel formulations in the market for antimicrobial drug. Increased occurrence of onychomycosis in recent times and because of involvement of occupation, socio-economic status, climate, gender, age and genetic and immune factors it is need of hour to explore the newer formulation with better efficacy. The goal of this study was to use the topical nanoemulsion in gel form for onychomycosis. As, topically applied product is more acceptable than oral product but topically applied product have its own disadvantages. To overcome those nanoemulsion in gel form was prepared. Nanoemulsion was developed using low energy emulsification technique. Nanoemulsion was found to have drug content of 98.03±0.265, globule size 230±0.2 and zeta potential of -0.3mV, converted to a gel using apt polymer. Nanogel thus formed showed better permeation through hoof nail and was having...
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