Posted by admin on Jul 31, 2026 in |
The current study aims to assess whether circulating levels of 25(OH) D are related to insulin resistance in PCOS individuals, or whether this association is confounded by other pathophysiological factors related to the syndrome. This cross-sectional study included 151 women who were diagnosed with PCOS based on the Rotterdam consensus, recruited from a tertiary healthcare center in South Gujarat, India. Data collection encompassed anthropometric parameter (BMI and WC) and biochemical indices (fasting blood glucose, fasting insulin, HOMA-IR, and serum 25(OH)D levels). Vitamin D levels were used to classify participants into three distinct categories: deficiency (serum 25(OH) D level <20 ng/mL), insufficiency (serum 25(OH)D level 20–32 ng/mL), and sufficiency (serum 25(OH)D level>32 ng/mL). From the total participants, 115 (76.15%) exhibited suboptimal serum 25(OH)D levels. Insulin resistance is characterized by HOMA-IR value (>2.5) and QUICKI value (<0.349), was observed in 69.5% of the cohort. While a substantial proportion74.3% of individuals with low level of vitamin D also demonstrated insulin resistance. Kruskal-Wallis test revealed a non-significant difference in IR across vitamin D...
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Posted by admin on Jul 31, 2026 in |
Optimization of culture conditions to enhance bioactive metabolite production by Micrococcus antarcticus HC-2 was undertaken in this study. The culture broth, grown in Yeast Extract–Malt Extract–Dextrose (ISP-2) medium and extracted with Ethyl acetate exhibited high antimicrobial activity against test microorganisms, including Gram-negative, Gram-positive bacteria and fungi. For efficient production of secondary metabolites, the optimal pH and temperature were found to be 7 and 30°C, respectively. Compared to other media, the Yeast Extract–Malt Extract–Dextrose broth produced a higher amount of bioactive metabolites. Studies on culture conditions revealed that maximum secondary metabolite synthesis was achieved when lactose (0.5%) and yeast extract (0.5%) were used as carbon and nitrogen sources,...
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Posted by admin on Jul 31, 2026 in |
Pomegranate (Punica granatum L.) seeds represent a biologically rich and underutilized by-product of fruit processing whose therapeutic potential has gained considerable scientific interest in recent years. This study presents a systematic phytochemical investigation of the ethanolic seed extract of Punica granatum, encompassing both qualitative screening and rigorous quantitative estimation of the phytoconstituents present. The extraction was performed using ethanol as the solvent system, chosen for its broad-spectrum efficacy in isolating both polar and semi-polar bioactive compounds, using Soxhlet extraction. A total of 50 g of dried seed powder was extracted using 500 mL of 95% ethanol in a Soxhlet apparatus for 8 hours, yielding 6.34 g of dried extract (extractive yield: 12.68% w/w). Qualitative analysis confirmed the presence of alkaloids, phenols, terpenoids, and glycosides; whereas flavonoids, tannins, and saponins were absent under the applied test conditions. Quantitative analysis revealed a total alkaloid content of 4.397 µg AE/g DE, a corrected total phenolic content (TPC) of 13.96 ± 0.42 mg GAE/g DE, and a Baljet-reactive glycoside content of 224.372 ±...
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Posted by admin on Jul 31, 2026 in |
The prescription writing process by prescriber is a very important step, and prescription error can lead to irrational use of medicine. The objective of the research is to describe and evaluate drug utilization patterns using WHO core indicators at the tertiary level. This is prospective observational study which was carried out in indoor IHD patients (IPD). WHO drug prescribing indicators were used to assess the drug utilization pattern. A total of 400 patients with IHD were recruited for the study. The cardiovascular class accounted for 68.02% of all drugs prescribed. 29.82% of FDCs in total drugs were prescribed in this study. The percentage of prescriptions with injections and antibiotics prescribed was 84.25% and 4% respectively. A total of 3743 drugs were prescribed, with an average of 9.36 ± 0.88 drugs per prescription. All drugs (100%) were prescribed with a generic name. 98% drugs were from essential drug list (Rajasthan-2019). The percentage of prescriptions with prescriptions for injections and the average number of drugs per prescription were much higher than...
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Posted by admin on Jul 31, 2026 in |
Background: Pregnancy-induced hypertension (PIH) is one of the leading causes for maternal mortality and morbidity among pregnant mothers in India. PIH is characterized by elevated blood pressure at or above 140/90 mmhg during pregnancy. Adequate knowledge, positive attitude and practises are at most important among the hypertensive mothers for proper management and prevention of maternal and neonatal complications during pregnancy. Objective: To assess the level of knowledge, attitude and practise (KAP) regarding pregnancy-induced hypertension (PIH) among hypertensive antenatal mothers attending Antenatal clinics in OG department, Government Medical College, Kallakurichi district, Tamil Nadu. Methods: A hospital based cross sectional study was conducted to assess the Knowledge, Attitude, and Practice among hypertensive antenatal mothers attending antenatal clinics in OG department, regarding PIH using a pre-tested semi-structured questionnaire for a period of 3months from October to December 2024. The present was done using convenience sampling technique and the final sample size calculated was 101 participants. Data was analysed using SPSS software version 21. Results: A total of 101 antenatal mothers participated in...
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