Posted by admin on Aug 31, 2026 in |
A stable multicomponent crystalline phase involving an anti-cancer agent (5-Fluorouracil, 5-FU) and an immunomodulator (Levamisole, LM) was developed through a systematic descriptor-guided screening workflow. Binary 5-FU/LM combinations failed to yield new solid phases, as assessed by Fourier Transform Infrared Spectroscopy (FTIR), a finding rooted in the complete absence of hydrogen bond donor functionality (HBD = 0) in levamisole. A composite descriptor-based coformer ranking algorithm, implemented in Python using RDKit, evaluated nine pharmacopoeially acceptable coformers against hydrogen bond donor-acceptor complementarity, topological polar surface area (TPSA), and LogP compatibility. Citric acid (CA) ranked first, driven by its hydrogen bonding capacity (HBD = 4, HBA = 4) and elevated TPSA. Twelve ternary formulations (5-FU/LM/CA) were prepared by solvent evaporation and anti-solvent addition across three molar ratios in water and EtOH:Water co-solvent systems. Quantitative FTIR descriptors served as inputs to a gradient boosting classifier for objective formulation ranking. F11 (1:2:1 molar ratio, anti-solvent addition, EtOH:Water) and F12 (same composition, solvent evaporation) emerged as the highest-ranked systems. New crystalline phases were confirmed in both...
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Posted by admin on Aug 31, 2026 in |
Background: Generic medicines are cost-effective alternatives to branded medicines with comparable quality, safety, and efficacy. Despite government initiatives promoting their use in India, their utilization remains inconsistent. Objective: To assess the knowledge, attitudes, and practices (KAP) regarding generic medicines among an urban population in Delhi, India. Methods: A cross-sectional study was conducted from September to November 2025 among adults aged ≥18 years in Delhi using convenience sampling. Data were collected through both online and offline modes using a structured, prevalidated bilingual (English and Hindi) questionnaire developed from previously validated tools. Content validity was assessed through expert review, and pilot testing was conducted among 20 participants prior to data collection. The questionnaire demonstrated good internal consistency reliability (Cronbach’s alpha = 0.8). Of 408 responses received, 397 complete responses were included in the final analysis. Descriptive statistics were performed using Microsoft Excel 2021. Results: Among the 397 participants, 49.4% were university students and 50.6% belonged to the general population. Overall, 83.0% were aware of generic medicines, while 76.5% recognized that they...
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Posted by admin on Aug 31, 2026 in |
High altitude hypoxia exposure contributes in oxidative stress, leading to cellular damage and disrupting normal cellular function. The aim of the present study was to assess the effect of beetroot juice (BRJ) supplementation on oxidative stress, inflammation and neuroendocrine changes imposed in individuals upon high altitude exposure. This was a randomized controlled, longitudinal study conducted at an altitude of 3300m in western Himalayas. A total of 92 individual were assessed during the study (control=40, beetroot juice supplemented=52). 200ml of BRJ was supplemented for 15 days after reaching high altitude. Serum, plasma and saliva samples were collected at sea level (SL) and high altitude (before and after commencement of supplementation) for the measurement of biomarkers of oxidative stress, antioxidants, inflammation, and neuroendocrine function. Exposure to high altitude significantly disrupt the redox homeostasis in both groups. A significant increase (p<0.001) in reactive oxygen species (ROS), c-reactive protein (CRP), interleukin-6 (IL-6) and malondialdehyde (MDA) while a decrease in total antioxidant capacity (p<0.001) was observed in both groups upon high altitude exposure. However,...
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Posted by admin on Aug 31, 2026 in |
Breast cancer is the most common malignancy affecting women worldwide. Molecular docking is an important computational technique in drug discovery interaction between ligands and target proteins. In present study docking analysis binding affinity of 51 heterocyclic ligands against the breast cancer target protein NUDT5 (PDB ID:5NWH) are nucleotide- metabolizing enzymes (NUDIX) hydrolases. It plays a major role in hormone- dependent gene regulation and proliferation in breast cancer cells. The heterocyclic ligands docking analysis were analyzed by Autodock 4.0.1. The docking was validated by re docking co-crystallized inhibitor 9CH into active binding site of NUDT5 protein and evaluated binding energy, RMSD values and molecular interactions. The results were found ligand “GR39 exhibited the lowest binding energy” (-14.12kcal/mol), when compared with reference inhibitor 9CH [-10.59kcal/mol] and standard drugs like STD1 Tamoxifen (-9.65), STD2 Cyclophosphamide (-5.83), STD3 Doxorubicin (-11.74). However the present study is limited to molecular docking analyis. Further studies include in-vitro, in-vivo, ADME and cytotoxicity...
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Posted by admin on Aug 31, 2026 in |
Background: Chronic Suppurative Otitis Media (CSOM) is a common childhood ear disease that can adversely affect hearing, speech and language development, educational performance, and quality of life. Information on the clinical profile and associated characteristics of affected children is important for planning preventive and management strategies, particularly in resource-limited settings. Methods: An institution-based cross-sectional study was conducted over a six-month period among 90 school-going children aged 6–14 years diagnosed with CSOM at a tertiary care centre. Participants were enrolled by consecutive sampling. Data regarding sociodemographic characteristics, clinical profile, healthcare-seeking behaviour, caregiver knowledge, and environmental factors were collected using a structured questionnaire. Otomicroscopy was done. Data were analysed using SPSS version 16.0 and presented as frequencies and percentages. Results: Of the 90 children studied, 58 (64.4%) were males and 32 (35.6%) were females. Active ear discharge was the most common presenting complaint (45.5%), followed by hearing loss (38.8%) and ear pain (12.2%). Bilateral disease was observed in 52.2% of cases. Frequently reported characteristics among children with CSOM included exposure to...
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