Posted by admin on Dec 1, 2013 in |
Herbal and natural products of folk medicine have been used for centuries in every culture throughout the world. Scientists and medical professionals have shown increased interest in this field as they recognize the true health benefits of these remedies. Spinach is a leafy green vegetable that came originally from south-western Asia and is now grown in most parts of the world. Scientifically it is known as Spincia oleracea Linn. (Family-Chenopodiaceae). It is a good source of the bioflavonoid quercetin with many other flavonoids which exhibits anti-oxidant, anti-proliferative, anti-inflammatory, antihistaminic, in addition to its many other benefits. Treatment with Spinacia oleraceae (200mg/kg body wt) decreases the immobility time against forced swim test and tail suspension test. Fluoxetine (30mg/kg, i.p) was selected as reference standard and it showed significant antidepressant activity in rodents. Results suggest that Spinacia oleraceae exerts anti-depressant activity as shown by its effects on different experimentally induced different...
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Posted by admin on Dec 1, 2013 in |
The present study was undertaken to explore the tumor take inhibitory effects of ethanolic extract of Murraya koenigii in rodents. Tumor take inhibitory activity was investigated in hybrid mice (of C57BL strain + Swiss albino strain). Preventive group animals were injected daily with the extract at dose of 50mg/kg body weight i.p. for 10 consecutive days. The animals were observed for the growth of tumor after injection of B16F10 melanoma cells into the dorsal skin of mice. Pretreatment with the extract and showed delay tumor growth by increasing the volume doubling time, VDT (p<0.01), growth delay, GD (p< 0.01) and mean survival time, MST (p<0.001). Tumor regression studies showed a regression response for tumor growth in vivo of murine mouse melanoma tumor cell lines, demonstrated by increasing the VDT and...
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Posted by admin on Dec 1, 2013 in |
Central pathogenic mechanism of Alzheimer’s disease (AD) involves aggregation of amyloid β (Aβ) protein to form toxic oligomers. Identifying novel small molecules that inhibit the aggregation of monomeric Aβ to toxic oligomeric species can be an effective disease modifying strategy for AD. In the present study, plants being used in Ayurveda for treating dementia as well as to improve memory and cognitive function have been considered. These included Nelumbo nucifera, Valeriana wallichii, Celastrus paniculatus, and Raulfia serpentina. We tested the efficacy of these plant extracts and some of their active ingredients for their anti-amyloidogenic property by means of in vitro aggregation studies. The effect of each extract or phytocompound was tested on inhibition of aggregation as well as dissociation of preformed aggregates using thioflavin T fluorescence assay and transmission electron microscopy. Of the compounds screened, β-sitosterol and valerenic acid prevented the aggregation of Aβ while α-asarone and glycyrrhizin were effective in dissociating the preformed aggregates. More importantly, all the four phytocompounds have conferred protection against Aβ mediated toxicity in...
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Posted by admin on Dec 1, 2013 in |
Celastrus paniculatus is an important medicinal plant used in India. Traditionally seed oil of this herb is used widely in several medicinal preparations and its bark is used in malaria in folk medicines. It is endangered and vulnerable plant. The investigation used Reducing power assay and Total phenolic content to determine antioxidant potential in the ethanolic extract of the drug. The result showed significant reducing power activity and good phenolic content ability of the sample. The extract of leaves may be considered as good antioxidant...
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Posted by admin on Dec 1, 2013 in |
An analytical method has been developed for quantitative determination of diltiazem, chemically (+)-cis-1,5-benzothiazepin-4-(5H)one, 3-(acetyloxy)-5-[2-(dimethyl amino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-monohydro chloride, by complexation with Pd(II) spectrophotometrically. Diltiazem is a calcium channel blocker type antihypertensive drug. Diltiazem forms an stable orange colored 1:2 complex with Palladium(II) Chloride with lmax 400nm, molar absorptivity coefficient of complex e= 8.5 X102 l mol-1cm-1, Beer’s law range 3.413 X101 mg/ml to 2.722 X102 mg/ml with intercept of regression 0.019 and correlation coefficient 0.989. Interference of foreign metal ions and effect of temperature and pH was also studied. The characterization of complex involves, Elemental Analysis, FTIR, 1H NMR, ESR, Raman spectra, magnetic susceptibility measurement and thermal studies. On the basis of above studies structure of the complex has been proposed. The developed analytical method was applied on in-vivo blood samples- whole blood and serum samples. For whole blood samples Beer’s law range is 1.01 X 102 mg/ml to 2.77 X 102 mg/ml with coefficient of variance ±1.49 and relative standard deviation 0.64% and for serum samples Beer’s law range is...
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